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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Astrocytes display ultrastructural alterations and heterogeneity in the hippocampus of aged APP-PS1 mice and human post-mortem brain samples

Fig. 2

Intracellular contents of typical astrocytes in the stratum radiatum. Representative 5 nm per pixel of resolution scanning electron microscopy images acquired in the ventral hippocampus CA1 stratum radiatum of 20-month-old APP-PS1 (far from Aß plaques/dystrophic neurites) and age-matched C57BL/6J male mice (A, B). Quantitative graphs representing the number of primary lysosomes (C), tertiary lysosomes (E), and lipid bodies (G) are provided. Quantitative graphs represent the relative proportion of cells positive for primary lysosomes (D), tertiary lysosomes (F), and lipid bodies (H). Data are shown as individual dots and are expressed as mean ± S.E.M. *p < 0.05, ***p < 0.001, using a non-parametric Mann–Whitney test. Statistical tests were performed on n = 8–11 astrocytes per animal in N = 3 mice/group, for a total of 59 cell bodies analyzed. Red outline = plasma membrane, yellow outline = nuclear membrane, blue arrow = primary lysosomes, green arrow = secondary lysosomes, orange arrow = tertiary lysosomes, orange pseudo-coloring = lipid bodies

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