Fig. 8

Dark astrocytes are associated with AD hallmarks. Representative 5 nm per pixel of resolution scanning electron microscopy images of a dark astrocyte (A, B) in the ventral CA1 hippocampus stratum lacunosum-moleculare of 20-month-old APP-PS1 male mice. In A and B the  astrocyte is directly interacting with an Aß plaque where a specific segment (shown in B with a green bar) is becoming electron-dense compared to the rest of the cell. Yellow outline = nuclear membrane, purple outline = dark astrocytic cytoplasm, red outline = typical astrocytic cytoplasm, pink pseudo-coloring = dystrophic neurites, purple pseudo-coloring = amyloid beta plaques, green bar = electron-dense area