Fig. 10From: NOD-like receptor NLRC5 promotes neuroinflammation and inhibits neuronal survival in Parkinson’s disease modelsDiagram of Nlrc5 in regulating neuroinflammation and neuronal survival. In glial cells the pro-inflammatory signalings NF-κB and MAPK are suppressed by Nlrc5 deficiency, and AKT–GSK3β and AMPK pathways was enhanced. In neurons, Nlrc5 deficiency causes upregulation of NF-κB and AKT, which promotes the survival of neuronsBack to article page