Fig. 5

The expression of inflammatory molecules in the striatum of WT and Nlrc5^−/− mice at 3 days after MPTP administration. A, B Transcriptions of Iba1 and Gfap in the striatum. C Transcriptions of IL-1β (i), NLRP3 (ii), ASC (iii) and IL-18 (iv). D, E Protein levels of IL-1β in the striatum detected by Western-Blot. F, G Transcriptions of COX2 and C1q in the striatum. H The expression of anti-inflammatory molecules including TGF-β (i), IL-10 (ii), BDNF (iii) and Drd2 (iv) detected by qPCR. All data were presented as the means ± SEM. n = 4–6. * or ^#p < 0.05, ** or ^##p < 0.01, and *** or ^### p < 0.001