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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Inflammasome inhibition protects dopaminergic neurons from α-synuclein pathology in a model of progressive Parkinson’s disease

Fig. 2

MCC950 reduces the number of NLRP3-positive cells in the substantia nigra (SN) of hαSYN mice. a Representative images of SN brain sections stained with NLRP3. b Number of NLRP3+ cells (per area) in the SN of all experimental groups are indicated. Asterisks (*) indicate significance level. Statistical analysis by one-way ANOVA followed by Tukey’s multiple comparisons test: F(3, 24) = 19.04, P < 0.0001; *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Data are shown as mean ± standard error of the mean. n = 7 biologically independent, randomly selected samples for each group investigated. Scale bars: overview (left) = 250 µm; detail (right) = 100 µm

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