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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Inflammasome inhibition protects dopaminergic neurons from α-synuclein pathology in a model of progressive Parkinson’s disease

Fig. 5

Analysis of behavior and DA neuroprotection related to NLRP3-inflammasome inhibition. a Evaluation of right paw preference in the cylinder test. Statistical analysis by Kruskal–Wallis test followed by Dunn’s multiple comparisons test: Kruskal–Wallis statistic = 23.30, P < 0.0001, n—numbers: empty vector (EV)veh = 20, EVMCC = 18, hαSYNveh = 18, hαSYNMCC = 20. b Evaluation of relative latency to fall from the rotarod. Statistical analysis by one-way ANOVA followed by Tukey’s multiple comparisons test: F(3, 34) = 8.845, P = 0.0002, n—numbers: EVveh = 7, EVMCC = 11, hαSYNveh = 10, hαSYNMCC = 10. c Estimated cell count of TH+ cells in the substantia nigra (SN). Statistical analysis by one-way ANOVA followed by Tukey’s multiple comparisons test: F(3,31) = 13.33, P < 0.0001, n—numbers: EVveh = 10, EVMCC = 7, hαSYNveh = 8, hαSYNMCC = 10. d Estimated Nissl+ cell count. Statistical analysis by one-way ANOVA followed by Tukey’s multiple comparisons test: F(3,31) = 9.815, P = 0.0001, n—numbers: EVveh = 10, EVMCC = 7, hαSYNveh = 8, hαSYNMCC = 10. e Correlation analysis of estimated TH+ and Nissl+ cell count. f Relative optical density of anti-TH immunoreactivity on the ipsilateral side compared to the contralateral side of the striatum. Statistical analysis by one-way ANOVA followed by Tukey’s multiple comparisons test: F(3,31) = 9.606, P = 0.0001, n—numbers: EVveh = 10, EVMCC = 7, hαSYNveh = 8, hαSYNMCC = 10. g Correlation analysis of estimated TH+ cell count and optical density of anti-TH immunoreactivity in the corresponding striatum. h Representative RGB color images of right SN and striatum for each group. Scale bars: 200 µm (SN) and 500 µm (striatum). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Data are shown as mean ± standard error of the mean

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