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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Activation of HCA2 regulates microglial responses to alleviate neurodegeneration in LPS-induced in vivo and in vitro models

Fig. 6

Effect of HCA2 on the expression of pro-inflammatory and anti-inflammatory mediators in the BV2. We, respectively, treated BV2 cells with SiHCA2 (25 nM, 24 h), MK2206 (10 μM, 4 h) and SiPPARγ (25 nM, 24 h), and then treated with NA (1 mM) and LPS (100 ng/mL) for 24 h. After that, we examined the expression of pro-inflammatory mediators [IL-6 (A), TNF-α (B), iNOS (C) and COX2 (D) and anti-inflammatory mediators (Ym-1(E), CD206 (F), Arg-1 (G) and IL-10 (H)) using real-time PCR. Results are presented as mean ± SD (n = 3). *p < 0.05, **p < 0.01, ***p < 0.001 means significant difference and ns means not significant

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