Fig. 7From: Activation of HCA2 regulates microglial responses to alleviate neurodegeneration in LPS-induced in vivo and in vitro modelsEffect of HCA2 on the expression of iNOS and Arg-1 in microglia. We, respectively, treated BV2 cells with SiHCA2 (25 nM, 24 h), MK2206 (10 μM, 4 h) and SiPPARγ (25 nM, 24 h), and then treated with NA (1 mM) and LPS (100 ng/mL) for 24 h. After that, we examined the expression of iNOS and Arg-1 in microglia. A The expression of iNOS was detected using the immunofluorescence staining (the bar represents 20 μm). B The expression of Arg-1 was detected using the immunofluorescence staining (the bar represents 20 μm)Back to article page