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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: Activation of HCA2 regulates microglial responses to alleviate neurodegeneration in LPS-induced in vivo and in vitro models

Fig. 9

Effect of nicotinic acid (NA) on midbrain dopaminergic neuron damage and striatal dopamine levels in LPS-injected mice in the presence or absence of HCA2 on microglia. A Mouse handling flowchart. B, C The number of TH-positive cells in the substantia nigra (SN) of the mouse midbrain, as detected by immunohistochemistry (the bar represents 50 μm). D, E TH protein in mouse midbrain, as detected using the western blotting method. F, G The levels of dopamine and its metabolites (DOPAC) in mouse striatum, as detected by HPLC technique. Results are presented as mean ± SD (n = 3). *p < 0.05, **p < 0.01, ***p < 0.00 means significant difference

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