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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: The short isoform of MS4A7 is a novel player in glioblastoma microenvironment, M2 macrophage polarization, and tumor progression

Fig. 1

Expression of MS4A7 in GAMs of GBM tissue and its potential functions. A Schematic illustration of comprehensive strategies for identifying the target membrane protein. B UMAP plot shows different clusters of cells from scRNA-seq data. C Dot-plot of MS4A7, CD68 and CD163 expression levels among different types of cells. D Volcano plot of targeted membrane proteins upregulated in GBM tissues against normal tissues of TCGA GBM samples (adjusted P-value < 0.05 and log2fold change ≥ 1). E Box plot shows the mRNA expression level of MS4A7 between TCGA glioma samples (GBM and LGG) and GTEx normal brain tissues. F Box plot shows the mRNA expression level of MS4A7 among classical, mesenchymal and proneural subtypes of GBM. G Kaplan–Meier survival curves for GBM patients stratified by the PSI of MS4A7 exon 3 based on the clinical information from TCGA. H Enrichment plots of the signaling pathways up-regulated in the MS4A7-high expression phenotype from GSEA based on the TCGA-GBM dataset. I, J The correlation of MS4A7 with CD163 and IFNG mRNA expression was analyzed with Pearson’s test. Data were obtained from the TCGA databases. K Box plot shows the results of immunocellular component analysis based on TCGA GBM data using the CIBERSORT algorithm. Statistical significances were analyzed by Wilcoxon test (E, K) and one-way ANOVA (F). *P < 0.05; ***P < 0.001

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