Table 1 Effect of targeted α7 nAChR on depressive-like behavior
Compound type | Compound name | Study subject | Intervention | Outcome | References |
|---|---|---|---|---|---|
Male C57BL/6 | Knock-out α7 nAChR | Presence of depressive-like behavior | |||
α7 nAChR agonist | PNU282987 | Male Wistar rats | FST was performed after 24 h of administration (0.5 mg/kg) | Significantly improve depressive-like behavior | [183] |
Male adult Sprague–Dawley rats | CUMS induced depression 4 weeks and FST was performed after 35 min of administration (1 mg/kg) | Significantly improve depressive-like behavior | [185] | ||
C57BL/6 mice | Aβ1-42-induced depression, and FST was performed after 10 days of administration (1 mg/kg) | Significantly improve depressive-like behavior | [186] | ||
DMXBA(GTS-21) | Male Kunming mice | CRS-induced depression, FST, TST, and SPT were performed after 11 days of continuous administration (4 mg/kg) | Significantly improve depressive-like behavior | [184] | |
Type I PAMs | NS-1738 | Male Wistar rats | FST was performed after 24 h of administration (1 mg/kg) | Does not significantly improve depression-like behavior | [183] |
Male C57BL/6J mice | FST and TST were performed after 30 min, 7 days and 14 days of administration (1 mg/kg, 10 mg/kg), respectively | Depression-like behavior was significantly improved after 7 days of administration (1 mg/kg, 10 mg/kg) | [163] | ||
Type II PAMs | PNU-120596 | Male C57BL/6J mice | LPS was injected after 0.5 h of administration (4 mg/kg), and TST and SPT were performed after 26 h of LPS injection, and FST was performed after 28 h of LPS injection | LPS-induced depression-like behavior was blocked, but the antidepressant effect was reversed by MLA (3 mg/kg) | [192] |
LPS was injected after 0.5 h of administration (4 mg/kg), and FST was performed after 28 h of LPS injection | LPS-induced depression-like behavior was blocked, but the antidepressant effect was reversed by MLA (3 mg/kg) | [193] | |||
FST and TST were performed after 30 min, 7 days and 14 days of administration (1 mg/kg, 10 mg/kg), respectively | Depression-like behavior was significantly improved after 7 days of administration (1 mg/kg, 10 mg/kg) | [163] | |||
PAM-2 | C57BL/6J mice | FST were performed after 1 h, 7 days, 14 days and 21 days of administration (1 mg/kg), respectively | Depression-like behavior was significantly improved after 7 days, 14 days, and 21 days of administration (1 mg/kg) | [194] | |
Male C57BL | FST and TST were performed after 30 min, 7 days and 14 days of administration (0.5 mg/kg, 1 mg/kg), respectively | Depression-like behavior was significantly improved after 7 days and 14 days of administration (0.5 mg/kg, 1 mg/kg) | [163] |