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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: TREM2 deficiency inhibits microglial activation and aggravates demyelinating injury in neuromyelitis optica spectrum disorder

Fig. 2

TREM2 knockout exacerbates CNS damage in the mouse model of NMOSD. A Timeline of experiment process after AQP4-IgG and human complement injection. Mice were killed after 7 days post-injection (dpi). B Representative images of Iba1 (red) and TREM2 (green) immunostaining in the striatum of WT and TREM2−/− mice with NMOSD. Scale bar, 30 μm. C Representative images of AQP4 (red), GFAP (green) and dMBP (red) immunostaining and luxol fast blue (LFB) staining in WT and TREM2−/− mice with NMOSD. Scale bar, 500 μm. D Quantification of the loss area of AQP4, GFAP and myelin and the area of dMBP staining in WT and TREM2−/− mice with NMOSD. N = 5 mice/group, n = 10 fields/group, by Mann–Whitney U test. E Representative images of DAPI (blue), Olig2 (green), PDGFRα (red), Ki67 (green) and GST-PI (red) immunostaining in the striatum of WT and TREM2−/− mice with NMOSD. Scale bar, 50 μm. F Quantification of the number of Olig2+ cells, the ratio of PDGFRα+Ki67+/ PDGFRα+ cells, and the number of GST-PI+ cells in WT and TREM2−/− mice with NMOSD. N = 5 mice/group, n = 10 fields/group, Mann–Whitney U test

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