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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: TREM2 deficiency inhibits microglial activation and aggravates demyelinating injury in neuromyelitis optica spectrum disorder

Fig. 3

TREM2 deficiency worsens neurological impairment in the mouse model of NMOSD. A Timeline of behavior test with or without AQP4-IgG and human complement injection. B Quantification of the Modified neurological severity score at 1, 3, 7 dpi of WT and TREM2−/− mice. N = 15 mice/group; ns, no significance, two-way ANOVA with Bonferroni multiple comparisons. C Quantification of the Novel Object Recognition test of WT and TREM2−/− mice with or without AQP4-IgG and complement injection (7dpi). N = 15 mice/group; two-way ANOVA with Bonferroni multiple comparisons. D and E Quantification of the 12 mm and 6 mm balance beam test of WT and TREM2−/− mice with or without AQP4-IgG and complement injection (7dpi). N = 15 mice/group; two-way ANOVA with Bonferroni multiple comparisons

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