Fig. 2
From: PARK7/DJ-1 in microglia: implications in Parkinson’s disease and relevance as a therapeutic target
Functions of DJ-1 in microglia. A DJ-1 binds the p47 (green) unit of the NADPH oxidase preventing oxidative burst. B By preventing the binding of KEAP1 (yellow) to NRF2 (red), DJ-1 activates NRF2, which acts as a transcription factor regulating anti-oxidative responses. C DJ-1–NRF2 axis inhibits the inflammasome activation via TRX1. D DJ-1 facilitates the interaction of SHP-1 with STAT1, thereby inhibiting the STAT1 pathway. E DJ-1 binds the p65 subunit of the NFκB, thereby inhibiting the activation of the NFκB pathway. NRF2 NF-E2 related factor 2, KEAP 1 Kelch-like ECH protein 1, TRX1 Thioredoxin-1, SHP-1 Src-homology 2-domain containing protein tyrosine phosphatase-1, STAT-1 Signal transducer and activator of transcription 1, IKbα NF-κB inhibitor α, NFκB nuclear factor kappa light chain enhancer of B cells. Figure created with www.BioRender