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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: CXCL13 contributes to chronic pain of a mouse model of CRPS-I via CXCR5-mediated NF-κB activation and pro-inflammatory cytokine production in spinal cord dorsal horn

Fig. 2

The expression of CXCR5 is increased in ipsilateral spinal cord dorsal horn of CPIP model mice. A qPCR analysis of gene expression level of Cxcr5 in ipsilateral SCDH of sham and CPIP model mice on Day 7. **p < 0.01 vs. sham. B Immunostaining showing CXCR5 expression in ipsilateral SCDH of CPIP mice on Day 14. Right panel: summary of normalized fluorescence intensity of CXCR5. All values were normalized with sham group. **p < 0.01 vs. sham. Scale bar indicates 50 μm. n = 5 mice/group. C Western blot showing CXCR5 expression in sham (left) and CPIP model (right) group on Day 0, 7 and 14. n = 5–7 mice/group. **p < 0.01 vs. CPIP D 0 group. DF Double immunostainings of CXCR5 with NeuN (D), GFAP (E) and Iba-1 (F). Quantification of cellular distribution was shown on the right (pooled from 4 to 5 mice/group). Scale bar indicates 50 μm. Student’s t test was used for comparisons in A, B. One-way ANOVA followed with Tukey post hoc test was used for comparisons in C

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