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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: CXCL13 contributes to chronic pain of a mouse model of CRPS-I via CXCR5-mediated NF-κB activation and pro-inflammatory cytokine production in spinal cord dorsal horn

Fig. 3

Spinal blocking CXCL13 attenuates mechanical allodynia of CPIP model mice. A Experimental protocol showing the time points for CPIP model establishment, intrathecal injections of CXCL13 neutralizing antibody (Ab, 20 ng/10 μl) or corresponding isotype control IgG (Iso IgG) and behavioral test. B 50% PWT in ipsilateral hindpaw after intrathecal CXCL13 Ab or Iso IgG treatment in CPIP and sham group. C 50% PWT in contralateral hindpaw. Two-way ANOVA with repeated measures followed by Tukey’s post hoc test was used for comparisons. n = 8 mice/group. **p < 0.01. NS: no significance

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