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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Prominent epigenetic and transcriptomic changes in CD4+ and CD8+ T cells during and after pregnancy in women with multiple sclerosis and controls

Fig. 1

Overview of the study. CD4+ and CD8+ T cells were isolated from women with MS and healthy controls (HC) that were longitudinally sampled throughout and after pregnancy (1st, 2nd, 3rd trimester and post-partum). For MS, samples were also included before pregnancy. RNA and DNA were extracted from resting and in vitro activated cells. RNA-sequencing was performed to investigate transcriptomic changes and genome-wide profiling of DNA methylation was performed using the Illumina Infinium DNA Methylation EPIC Array. Differentially expressed genes (DEGs) and differentially methylated genes (DMGs) were used to construct modules using the module inference tool DIAMOnD. BP before pregnancy, HC healthy controls, MS multiple sclerosis, PP post-partum

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