Fig. 4

Differential analysis in CD4⁺ and CD8⁺ T cells reveals a post-partum rebound. Alluvial plots for A CD4⁺ and B CD8⁺ cells in both pregnant women with MS and pregnant healthy controls (HC) showing all CpGs (methylation) and all genes (RNA-seq) that were either differentially expressed (nominal p≤0.05) or differentially methylated (nominal p≤0.05 and |Δβ|>0.05) during (3rd-1st) or after pregnancy (PP-3rd). The genes and CpGs are grouped based on their direction during and after pregnancy (red=hypomethylation or upregulated, blue= hypermethylation or downregulated). The number of genes and CpGs in each corresponding region are depicted in the figure. HC healthy controls, MS multiple sclerosis