Table 1 Study cohort characteristics
MS (n = 11) | HC (n = 7) | |
|---|---|---|
Samples | ||
Pre-pregnancy, n | 6 | N/A |
1st trimester, n; gw median (range) | 11; 10.0 (8.0–13.0) | 7; 11.9 (10.7–12.0) |
2nd trimester, n; gw median (range) | 11; 25.0 (23.1–26.3) | 7; 25.0 (24.6–26.3) |
3rd trimester, n; gw median (range) | 11; 35.0 (33.0–36.1) | 7; 35.0 (33.7–35.3) |
Post-partum, n; week median (range) | 11; 6.0 (3.7–7.0) | 7; 6.9 (4.3–12.9) |
Subject characteristics | ||
Age (years), mean ± SD | 31.8 ± 2.1 | 27.7 ± 3.4 |
BMI, mean ± SD | 23.9 ± 3.8 | 22.7 ± 3.1 |
Current pregnancy | ||
Gw at delivery, mean ± SD | 40.1 ± 0.9 | 39.3 ± 1.2 |
Fetal sex | 5 males/ 6 females | 3 males/ 4 females |
Mode of delivery | ||
Vaginal delivery, n | 10 | 7 |
Cesarean section, n | 1 | 0 |
Pregnancy history (mean ± SD) | ||
Parity | 0.6 ± 0.8 | 0.4 ± 0.8 |
Previous miscarriages | 0.3 ± 0.9 | 0.1 ± 0.4 |
Previous live births | 0.6 ± 0.8 | 0.4 ± 0.8 |
Disease parameters | ||
Disease duration, mean ± SD | 7.4 ± 6.2 | N/A |
Disease severity | ||
EDSS at inclusion, median (range) | 0.5 (0–2.5)* | N/A |
EDSS post-partum, median (range) | 0.5 (0–2.0) + | N/A |
Treatment | ||
Treatment washout (weeks) | ||
From pre-P sampling, median (range) | 8.0 (0–20.9) | N/A |
From 1st trimester sampling, median (range) | 14.9 (2.0–48.3) | N/A |