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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Dysbiosis of gut microbiota inhibits NMNAT2 to promote neurobehavioral deficits and oxidative stress response in the 6-OHDA-lesioned rat model of Parkinson’s disease

Fig. 5

Effects of FMT on neurobehavioral symptoms and oxidative stress response in 6-OHDA-lesioned rats. PD rat models were induced by 6-OHDA, followed by treatment with FMT (n = 8). A Expression of NMNAT2 in brain tissues of 6-OHDA-lesioned rats detected by ELISA. B Number of rotations of 6-OHDA-lesioned rats measured by apomorphine-induced rotation test. C Total distance of movement of 6-OHDA-lesioned rats measured by open field test. D Average speed of movement of 6-OHDA-lesioned rats measured by open field test. E Latency period of 6-OHDA-lesioned rats falling from the rotating rod measured by rotation test. F Dopaminergic neurons in the SN of 6-OHDA-lesioned rats detected by IHC. G NMNAT2 protein expression in the SN of 6-OHDA-lesioned rats detected by IHC. H MDA content in the brain tissues of 6-OHDA-lesioned rats. I GSH content in the brain tissues of 6-OHDA-lesioned rats. J GSH-Px activity in the brain tissues of 6-OHDA-lesioned rats. K SOD activity in the brain tissues of 6-OHDA-lesioned rats. *p < 0.05; **p < 0.01; ***p < 0.001

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Journal of Neuroinflammation

ISSN: 1742-2094