Fig. 10

The activation of STING-dependent IFN-I cascades reduces acute and chronic alloknesis in mice. A DMXAA (i.p., 20 mg/kg) is injected at 60 min prior to compound 48/80 exposure. Alloknesis, induced 30 min after compound 48/80 treatment, is reduced by DMXAA pre-treatment. B Two injections of DMXAA (i.p., 20 mg/kg) are given daily from day 1 to 2 after AEW treatment. Alloknesis, induced after AEW-induced dry skin, is reduced by DMXAA pre-treatment. C and E Recombinant IFN-α and IFN-β (i.t., 100 U) are injected at 60 min prior to compound 48/80 exposure. Alloknesis, induced 30 min after compound 48/80 treatment, is reduced by recombinant IFN-α and IFN-β. D and F Two injections of recombinant IFN-α and IFN-β (i.t., 100 U) are given daily from day 1 to 2 after AEW treatment. Alloknesis, induced after AEW-induced dry skin, is reduced by recombinant IFN-α and IFN-β. Data are expressed as mean ± SD and analyzed by two-way ANOVA with Bonferroni post hoc test. n = 8 mice/group. n.s., not significant