Fig. 11

The murine STING agonist DMXAA prevents the changes of brain functional connectivity in dermatitis-induced chronic pruritus in mice. DMXAA (i.p., 20 mg/kg) was injected daily from days 3 to 4 after DCP treatment in contact dermatitis model. A–G Regions of interest (ROI)-ROI functional connectivity differences are examined between different groups on day 5 following DCP. The vertical axes represent the z-value of the ROI-ROI functional connectivity. H and I 3D representation of whole-brain ROI-ROI functional connectivity. n = 3 mice/group. Data are expressed as mean ± SD and analyzed by one-way ANOVA with Bonferroni post hoc test. Compared with group Control, ^*P < 0.05. Compared with group DCP + Vehicle, ^#P < 0.05. lCA1, left cornu ammonis 1; Col, colliculus; lEPC, left endo/piriform cortex; rIEC, right intermedial entorhinal cortex; rPC, right piriform cortex; lPC, Left piriform cortex; PN, pontine nuclei; PSC_A, primary somatosensory cortex (auditory); rPSC_BE, right primary somatosensory cortex (BE); rPSVC, right primary and secondary visual cortex; RC1, retrosplenial cortex 1; RC5, retrosplenial cortex 5; RN, raphe nuclei; rRPRN, right raphe pontine reticular nuclei; lStri, left striatum; VT, ventral thalamus; VTN, ventral tegmental nuclei