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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: STING controls opioid-induced itch and chronic itch via spinal tank-binding kinase 1-dependent type I interferon response in mice

Fig. 7

The cross-species STING agonist ADU-S100 reduces neuraxial opioids-induced acute itch and dermatitis-induce chronic itch in mice. A-C Intraperitoneal (i.p.) pre-administration of ADU-S100 attenuates i.t. morphine-, fentanyl-, and sufentanil-induced scratching behavior. D and E ADU-S100 does not affect i.d. compound 48/80- and CQ-induced scratching behavior. F pre-treatment with ADU-S100 reduces AEW-induced scratching behavior. G pre-treatment with ADU-S100 reduces DCP-induced scratching behavior. Data are expressed as mean ± SD and analyzed by one-way ANOVA with Bonferroni post hoc test (A–E), and two-way ANOVA with Bonferroni post hoc test (F, G). n = 8 mice/group. n.s., not significant

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Journal of Neuroinflammation

ISSN: 1742-2094