Fig. 1

MCC950 improved CUMS-induced depressive-like behaviors and cognitive decline. A The sucrose preference in CUMS mice was lower than Control group, while MCC950 and fluoxetine could improve. B MCC950 and fluoxetine could reverse CUMS-induced prolonged tail suspension time. C MCC950 could reduce platform crossings numbers of CUMS mice, but fluoxetine could not. D MCC950, rather than fluoxetine, improved escape latency of CUMS mice. E, F The time of CUMS mice in the target quadrant was shortened, and both MCC950 and fluoxetine could relieve. The data were shown by mean and standard error (Mean ± SEM). (n = 9 for each group, *P < 0.05, **P < 0.01, ***P < 0.001)