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Fig. 10 | Journal of Neuroinflammation

Fig. 10

From: The involvement of NLRP3 inflammasome in CUMS-induced AD-like pathological changes and related cognitive decline in mice

Fig. 10

MCC950 alleviated the activation of Aβ metabolic pathway in BV2 cells. A The expression of target protein was detected by Western Blotting. B MCC950 inhibited the up-regulation of APP in BV2 cells induced by LPS + ATP. C MCC950 ameliorated the up-regulation of BACE1 induced by LPS + ATP. D MCC950 improved the down-regulation of IDE induced by LPS + ATP. The data were shown by mean and standard error (Mean ± SEM). (n = 4 for each group, *P < 0.05, **P < 0.01, ***P < 0.001)

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