Fig. 12

MCC950 reduced the activation of protein kinase related to tau protein phosphorylation. A The expression of target protein was detected by Western Blotting. B MCC950 inhibited the down-regulation of GSK-3β phosphorylation in primary neurons induced by the secretion of BV2 cells activated by LPS + ATP. C The secretion of BV2 cells activated by LPS + ATP induced the up-regulation of ERK1/2 phosphorylation in primary neurons, and the intervention of MCC950 could alleviate. The data were shown by mean and standard error (Mean ± SEM). (n = 3 for each group, *P < 0.05, **P < 0.01)