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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: The involvement of NLRP3 inflammasome in CUMS-induced AD-like pathological changes and related cognitive decline in mice

Fig. 5

MCC950 inhibited CUMS-induced activation of NLRP3 inflammasome. A The expression of target protein was detected by Western Blotting. B MCC950 inhibited the up-regulation of NLRP3 expression induced by CUMS. C Both MCC950 and fluoxetine could significantly inhibit CUMS-induced activation of Caspase-1 p10. D CUMS induced up-regulation of IL-1β expression, and both MCC950 and fluoxetine could inhibit. The data were shown by mean and standard error (Mean ± SEM). (n = 3 for each group, *P < 0.05, **P < 0.01)

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