Fig. 6

MCC950 restored CUMS-induced activation of Aβ metabolic pathway. A The expression of target protein was detected by Western Blotting. B Both MCC950 and fluoxetine could inhibit CUMS induced up-regulation of APP. C Both MCC950 and fluoxetine could relieve the increased expression of BACE1 induced by CUMS. D CUMS induced down-regulation of IDE, which could be improved by MCC950 and fluoxetine intervention. The data were shown by mean and standard error (Mean ± SEM). (n = 3 for each group, *P < 0.05, **P < 0.01)