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Table 1 Levels of TDP-43 (total and phosphorylated) measured by Western blot (see Additional file 1: Fig. S1 for representative blots) in different forebrain areas of FTD and wildtype male mice at PND90

From: Preclinical investigation in FAAH inhibition as a neuroprotective therapy for frontotemporal dementia using TDP-43 transgenic male mice

CNS structures

Marker

Wildtype mice

CamKII-TDP43 mice

mPFC

TDP-43

100.1 ± 5.9 (7)

157.8 ± 14.7 (5)***

p-TDP-43/TDP-43

100.0 ± 16.6 (6)

159.9 ± 18.6 (5)*

Hippocampus

TDP-43

100.0 ± 4.1 (6)

135.7 ± 12.5 (5)*

p-TDP-43/TDP-43

100.0 ± 19.4 (6)

129.4 ± 36.7 (5)

  1. Details in the text. Data correspond to percentages over the wildtype group and are expressed as means ± SEM with the number of animals per experimental group in parentheses. They were analysed by the unpaired Student’s t-test (*p < 0.05, **p < 0.01, ***p < 0.005 versus wildtype mice)
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