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Fig. 10 | Journal of Neuroinflammation

Fig. 10

From: β-arrestin1 regulates astrocytic reactivity via Drp1-dependent mitochondrial fission: implications in postoperative delirium

Fig. 10

Proposed working model of postoperative delirium triggered by astroglial β-arrestin1 deletion. Decreased β-arrestin1 in postoperative delirium induced astrocytic reactivity to facilitate the pathological progression. β-Arrestin1 deletion triggered the disassociation between with β-arrestin1 and cytoplasmic Drp1 to promote mitochondrial translocation of Drp1 and cause excessive mitochondrial fragmentation and mitochondrial dysfunctions. Activation of β-arrestin1-biased signaling by agonist recovers neurotoxic astrocytic reactivity and phenotypes of postoperative delirium mouse model

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