Fig. 2

Correlation matrix showing the associations between CSF proteins in control (A), MCI (B), AD (C), and DLB (D) groups. The correlation matrix heatmap represents Spearman’s correlation coefficient between inflammatory-related proteins (i.e., MIF, sTREM1, and sTREM2), the classical AD CSF biomarkers, and MMSE scores, stratified by clinical diagnosis. The blue color depicts a positive correlation coefficient, while red depicts a negative correlation coefficient. * P < 0.05, ** P < 0.01, *** P < 0.001. MCI mild cognitive impairment, AD Alzheimer’s disease, DLB dementia with Lewy bodies, MIF macrophage migration inhibitory factor, sTREM1 soluble triggering receptor expressed on myeloid cells 1, sTREM2 soluble triggering receptor expressed on myeloid cells 2, tTau total tau, pTau phosphorylated tau, Aβ42 amyloid-beta 1–42, MMSE mini-mental state examination