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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: IL-10 production by granulocytes promotes Staphylococcus aureus craniotomy infection

Fig. 7

Exogenous IL-10 inhibits S. aureus clearance in Mrp8CreIL-10 fl/fl mice. Mrp8CreIL-10 fl/fl mice and WT littermates received IL-10 containing (n = 11 WT and 12 Cre) or control (vehicle; n = 9 WT and 10 Cre) microparticles applied at the dorsal and ventral aspects of the bone flap on the day of S. aureus infection and were euthanized at day 14 to quantify bacterial burden in the brain, galea, and bone flap (*p < 0.05; **p < 0.01; ***p < 0.001; one-way ANOVA)

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