Fig. 5

Treatment of SCA1 mice with JNK inhibitor ameliorates the motor coordination impairment. A Schematic representation of treatment and assessment course. Mice were treated with either 15 mg/kg of JNK inhibitor or vehicle (10% DMSO and 90% corn oil) intraperitoneally (IP) until 4 months of age starting from 2 months. Then mice were rested for behavioral assays followed by pathological and quantitative RT-PCR analysis. B, C Rotarod performance of mice at B 3 months and C 4 months of age. D Mouse weight before IP administration (at 2 months of age) and following administration at 3 and 4 months of age. The number of animals used is shown in the histogram legends. *P < 0.05; **P < 0.01, two-way ANOVA with Bonferroni’s multiple comparisons test