Fig. 6

JNK inhibitor treatment improves Purkinje cell pathology in SCA1 mice. A Cerebellar slices from 4-month-old mice treated with either JNK inhibitor or vehicle were stained with calbindin antibody specific for Purkinje cells (red). Images are taken from same lobules (VII, VIII and IX) in each condition. The corresponding higher-magnification images (×20) shown below each panel. Sections were also stained for nuclei using DAPI (blue). Scale bar = 100 μm. B Quantification of molecular layer thickness (red). n = 4 mice. *P < 0.05; ****P < 0.0001, one-way ANOVA with Bonferroni’s multiple comparison test