Skip to main content
Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Inhibition of discoidin domain receptor (DDR)-1 with nilotinib alters CSF miRNAs and is associated with reduced inflammation and vascular fibrosis in Alzheimer’s disease

Fig. 3

miRNAs that target inflammation are significantly reduced in nilotinib treated patients. A total of 17 microRNAs (1.6%) were significantly different between the placebo and nilotinib groups, accounting for both treatment and time. Ingenuity Pathway Analysis of microRNA matched associated mRNAs or targets that are experimentally validated from TarBase, miRecords, as well as highly predicted miRNA–mRNA interactions from TargetScan and revealed that 9 of these microRNAs are associated with genes that regulate inflammation. N = 11 placebo, n = 12 nilotinib

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094