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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: The BET PROTAC inhibitor dBET6 protects against retinal degeneration and inhibits the cGAS-STING in response to light damage

Fig. 9

Schematic model for dBET6 protection against LD-induced retinal degeneration. During LD, retinal macrophages/microglia were transited from resting state to activated from, migrating into photoreceptor layer. Cytosolic DNA was accumulated in photoreceptors and cGAS-STING signaling was activated in retina. Reactive macrophages/microglia were recruited to photoreceptors with DNA leakage, and macrophages/microglia there exhibited increased STING expression. Degradation of BET proteins inhibited LD-induced macrophages/microglia activation and STING expression

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Journal of Neuroinflammation

ISSN: 1742-2094