Fig. 1

The suppression of synaptic plasticity and cognitive function in the BDL mouse brain cortex. A Illustration displaying the procedure of RNA sequencing in the BDL mice cortex tissues. B The movement of sham and BDL mice in T-maze were represented by illustration. The track line of movement indicates 10 min of measurement for five mice per group. In sham and MDL mice, the change in percentage of spontaneous alternation was expressed as mean ± SEM (n = 5) and shows the percentage of spontaneous alternation of T-maze test on days 1 and 3. In C–F, data were measured at days 1 and 3 during the experiment. C The number of entrances to arms, D the total length of mouse movement (cm), E the immobility time of mouse (seconds), and F the velocity of mouse movement (cm/s), for sham and BDL mice, respectively. Data were measured at days 1 and 3 during trials and were reported as the mean ± SEM (n = 3). G The measurement of PSD-95, SYP, and c-FOS protein levels in the sham and BDL mouse brain cortex. Data are represented as mean ± SEM (n = 3). An unpaired two-tailed t-test with Welch’s correction was used for statistical analysis. ns, not significant, *p < 0.05, **p < 0.01, ***p < 0.001