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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Circular RNA Tmcc1 improves astrocytic glutamate metabolism and spatial memory via NF-κB and CREB signaling in a bile duct ligation mouse model: transcriptional and cellular analyses

Fig. 6

circTmcc1 regulates spatial memory in BDL mice. A Illustration of brain osmotic pump-infused mouse model. The osmotic pump was infused into the lateral ventricle (mediolateral 1.0 mm, anteroposterior 0.3 mm, and dorsoventral 2.5 mm, with the bregma as the landmark). B The expression of circTmcc1 and Tmcc1 in the cortex of sham and BDL mice, respectively, is presented as the mean ± SEM (n = 3). C An illustration describing the movement of sham and BDL mice in the T-maze apparatus following infusion from an osmotic pump filled with either control siRNA or circTmcc1-siRNA mixtures. D The measurement of glutamate and glutamine concentration in the sham and BDL mice cortex following circTmcc1 knockdown. E The expression of proteins in sham and BDL mice cortex following circTmcc1 knockdown. p-p65 and p-CREB protein levels compared with total p65 and CREB protein levels. Data are represented as the mean ± SEM (n = 3). An unpaired two-tailed t-test with Welch’s correction was used for statistical analysis. ns, not significant, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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Journal of Neuroinflammation

ISSN: 1742-2094