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Page 44 of 51

  1. Content type: Research

    Apoptosis, neuroinflammation and blood-brain barrier (BBB) damage affect the susceptibility of the developing brain to hypoxic-ischemic (HI) insults. c-Jun N-terminal kinase (JNK) is an important mediator of i...

    Authors: Yi-Fang Tu, Yau-Sheng Tsai, Lan-Wan Wang, Hsin-Chieh Wu, Chao-Ching Huang and Chien-Jung Ho

    Citation: Journal of Neuroinflammation 2011 8:40

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  2. Content type: Research

    Autoimmunity to the central nervous system (CNS) may play a pathogenic role in a subgroup of patients with autism. This study aimed to investigate the frequency of serum anti-ganglioside M1 auto-antibodies, as...

    Authors: Gehan A Mostafa and Laila Y AL-ayadhi

    Citation: Journal of Neuroinflammation 2011 8:39

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  3. Content type: Research

    Previous studies indicate that successful resolution of Lyme neuroborreliosis (NB) is associated with a strong T helper (Th) 1-type cytokine response in the cerebrospinal fluid (CSF) followed by a down-regulat...

    Authors: Anna J Henningsson, Ivar Tjernberg, Bo-Eric Malmvall, Pia Forsberg and Jan Ernerudh

    Citation: Journal of Neuroinflammation 2011 8:36

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  4. Content type: Research

    The transcription factors CCAAT/enhancer binding proteins (C/EBP) α, β and δ have been shown to be expressed in brain and to be involved in regulation of inflammatory genes in concert with nuclear factor κB (N...

    Authors: Veronica Ramberg, Linda M Tracy, Malin Samuelsson, Lars NG Nilsson and Kerstin Iverfeldt

    Citation: Journal of Neuroinflammation 2011 8:34

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  5. Content type: Research

    Neuroinflammation and nitroxidative stress are implicated in the pathophysiology of neuropathic pain. In view of both processes, microglial and astroglial activation in the spinal dorsal horn play a predominan...

    Authors: Julie V Berger, Ronald Deumens, Stéphanie Goursaud, Sabrina Schäfer, Patricia Lavand'homme, Elbert A Joosten and Emmanuel Hermans

    Citation: Journal of Neuroinflammation 2011 8:33

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  6. Content type: Research

    Adaptation to hypoxia and consequent pro-inflammatory gene expression of prostate and breast carcinomas have been implicated in the progression toward cancer malignant phenotype. Only partial data are availabl...

    Authors: Marco Tafani, Maura Di Vito, Alessandro Frati, Laura Pellegrini, Elena De Santis, Giovanni Sette, Adriana Eramo, Patrizio Sale, Emanuela Mari, Antonio Santoro, Antonino Raco, Maurizio Salvati, Ruggero De Maria and Matteo A Russo

    Citation: Journal of Neuroinflammation 2011 8:32

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  7. Content type: Research

    Permanent functional deficits following spinal cord injury (SCI) arise both from mechanical injury and from secondary tissue reactions involving inflammation. Enhanced release of adenosine and glutamate soon a...

    Authors: Irene Paterniti, Alessia Melani, Sara Cipriani, Francesca Corti, Tommaso Mello, Emanuela Mazzon, Emanuela Esposito, Placido Bramanti, Salvatore Cuzzocrea and Felicita Pedata

    Citation: Journal of Neuroinflammation 2011 8:31

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  8. Content type: Research

    Changes in the gene expressions for tumor necrosis factor-α (TNF-α) and/or interleukin-1β (IL-1β) during tinnitus have not been previously reported. We evaluated tinnitus and mRNA expression levels of TNF-α, I...

    Authors: Juen-Haur Hwang, Jin-Cherng Chen, Shan-Ying Yang, Ming-Fu Wang and Yin-Ching Chan

    Citation: Journal of Neuroinflammation 2011 8:30

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  9. Content type: Research

    Status epilepticus (SE) is proposed to lead to an age-dependent acute activation of a repertoire of inflammatory processes, which may contribute to neuronal damage in the hippocampus. The extent and temporal p...

    Authors: Juha T Järvelä, Francisco R Lopez-Picon, Anna Plysjuk, Saku Ruohonen and Irma E Holopainen

    Citation: Journal of Neuroinflammation 2011 8:29

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  10. Content type: Research

    Tumor necrosis factor-α (TNF-α), a proinflammatory cytokine, is capable of activating the small GTPase RhoA, which in turn contributes to endothelial barrier dysfunction. However, the underlying signaling mechani...

    Authors: Jing Peng, Fang He, Ciliu Zhang, Xiaolu Deng and Fei Yin

    Citation: Journal of Neuroinflammation 2011 8:28

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  11. Content type: Research

    Microglial function is modulated by several factors reflecting the numerous receptors expressed on the cell surface, however endogenous factors which contribute to the age-related increase in microglial activa...

    Authors: Anthony Lyons, Kevin J Murphy, Rachael Clarke and Marina A Lynch

    Citation: Journal of Neuroinflammation 2011 8:27

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  12. Content type: Research

    Traumatic injury to axons produces breakdown of axons and myelin at the site of the lesion and then further distal to this where Wallerian degeneration develops. The rapid removal of degenerated myelin by phag...

    Authors: Miri Gitik, Sigal Liraz-Zaltsman, Per-Arne Oldenborg, Fanny Reichert and Shlomo Rotshenker

    Citation: Journal of Neuroinflammation 2011 8:24

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  13. Content type: Research

    Dengue, one of the most important arboviral diseases of humans, may cause severe systemic disease. Although dengue virus (DENV) has been considered to be a non-neurotropic virus, dengue infection has been asso...

    Authors: Debora CG Amaral, Milene A Rachid, Marcia C Vilela, Roberta DL Campos, Gustavo P Ferreira, David H Rodrigues, Norinne Lacerda-Queiroz, Aline S Miranda, Vivian V Costa, Marco A Campos, Erna G Kroon, Mauro M Teixeira and Antonio L Teixeira

    Citation: Journal of Neuroinflammation 2011 8:23

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  14. Content type: Research

    Insulin-like growth factor-I (IGF-I) exerts neuroprotective actions in the central nervous system that are mediated at least in part by control of activation of astrocytes. In this study we have assessed the e...

    Authors: Maria J Bellini, Claudia B Hereñú, Rodolfo G Goya and Luis M Garcia-Segura

    Citation: Journal of Neuroinflammation 2011 8:21

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  15. Content type: Research

    Dorsal root reflexes (DRRs) are antidromic activities traveling along the primary afferent fibers, which can be generated by peripheral stimulation or central stimulation. DRRs are thought to be involved in th...

    Authors: Oleg V Lobanov and Yuan B Peng

    Citation: Journal of Neuroinflammation 2011 8:20

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  16. Content type: Research

    Non-neuronal cells, such as microglia and lymphocytes, are thought to be involved in the pathogenesis of amyotrophic lateral sclerosis (ALS). Previous studies have demonstrated neuroprotective effects of lymph...

    Authors: Satoru Tada, Tatsusada Okuno, Teruhito Yasui, Yuji Nakatsuji, Tomoyuki Sugimoto, Hitoshi Kikutani and Saburo Sakoda

    Citation: Journal of Neuroinflammation 2011 8:19

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  17. Content type: Research

    Activation of indoleamine 2,3-dioxygenase (IDO) and higher concentrations of several kynurenine metabolites have been observed post-stroke, where they have been associated with increased mortality. While lower...

    Authors: Allison B Gold, Nathan Herrmann, Walter Swardfager, Sandra E Black, Richard I Aviv, Gayla Tennen, Alexander Kiss and Krista L Lanctôt

    Citation: Journal of Neuroinflammation 2011 8:17

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  18. Content type: Research

    Stromal cell-derived factor-1 (SDF1) and its major signaling receptor, CXCR4, were initially described in the immune system; however, they are also expressed in the nervous system, including the spinal cord. A...

    Authors: Vicki M Tysseling, Divakar Mithal, Vibhu Sahni, Derin Birch, Hosung Jung, Richard J Miller and John A Kessler

    Citation: Journal of Neuroinflammation 2011 8:16

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    The Erratum to this article has been published in Journal of Neuroinflammation 2017 14:35

  19. Content type: Research

    Lipopolysaccharide (LPS), the major component of the outer membrane of gram-negative bacteria, can activate immune cells including macrophages. Activation of macrophages in the central nervous system (CNS) con...

    Authors: Jieliang Li, Li Ye, Denise R Cook, Xu Wang, Jinping Liu, Dennis L Kolson, Yuri Persidsky and Wen-Zhe Ho

    Citation: Journal of Neuroinflammation 2011 8:15

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  20. Content type: Short report

    Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that contributes to neuronal injury in various degenerative diseases, and is therefore a potential therapeutic target. It exerts its biological effect by a...

    Authors: Fabrizio Gardoni, Mariaserena Boraso, Elisa Zianni, Emanuela Corsini, Corrado L Galli, Flaminio Cattabeni, Marina Marinovich, Monica Di Luca and Barbara Viviani

    Citation: Journal of Neuroinflammation 2011 8:14

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  21. Content type: Research

    Sphingosine kinase 1 (SphK1), a key enzyme responsible for phosphorylating sphingosine into sphingosine-1-phosphate (S1P) has been shown to be expressed in monocytes and monocyte-derived peripheral macrophages...

    Authors: Haiyan Lin, Nimmi Baby, Jia Lu, Charanjit Kaur, Chuansen Zhang, Jiajun Xu, Eng-Ang Ling and S Thameem Dheen

    Citation: Journal of Neuroinflammation 2011 8:13

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  22. Content type: Research

    Exogenous administration of insulin-like growth factor (IGF)-I has anti-depressant properties in rodent models of depression. However, nothing is known about the anti-depressant properties of IGF-I during infl...

    Authors: Sook-Eun Park, Robert Dantzer, Keith W Kelley and Robert H McCusker

    Citation: Journal of Neuroinflammation 2011 8:12

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  23. Content type: Research

    Recent studies have suggested that the scavenger receptor MARCO (macrophage receptor with collagenous structure) mediates activation of the immune response in bacterial infection of the central nervous system ...

    Authors: Benedikt J Braun, Alexander Slowik, Stephen L Leib, Ralph Lucius, Deike Varoga, Christoph J Wruck, Sandra Jansen, Rainer Podschun, Thomas Pufe and Lars-Ove Brandenburg

    Citation: Journal of Neuroinflammation 2011 8:11

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  24. Content type: Research

    The neuropeptide substance-P (SP) is expressed from the TAC1 gene in sensory neurones where it acts as a key modulator of neurogenic inflammation. The promoter of TAC1 (TAC1prom) plays a central role in the re...

    Authors: Lynne Shanley, Marissa Lear, Scott Davidson, Ruth Ross and Alasdair MacKenzie

    Citation: Journal of Neuroinflammation 2011 8:10

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  25. Content type: Research

    Parkinson's disease is characterized by a progressive loss of dopaminergic neurons in the substantia nigra. The cause of the neurodegeneration is unknown. Neuroinflammation has been clearly shown in Parkinson'...

    Authors: Mibel M Pabon, Adam D Bachstetter, Charles E Hudson, Carmelina Gemma and Paula C Bickford

    Citation: Journal of Neuroinflammation 2011 8:9

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  26. Content type: Research

    Administration of exogenous interferon-γ (IFNγ) aggravates the symptoms of multiple sclerosis (MS), whereas interferon-β (IFNβ) is used for treatment of MS patients. We previously demonstrated that IFNγ induce...

    Authors: Makoto Horiuchi, Aki Itoh, David Pleasure, Keiko Ozato and Takayuki Itoh

    Citation: Journal of Neuroinflammation 2011 8:8

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  27. Content type: Research

    Hearing loss is a frequent long-term complication of pneumococcal meningitis (PM). Its main pathological correlate is damage to the organ of Corti and loss of spiral ganglion neurons. The only current treatmen...

    Authors: Cornelia Demel, Tobias Hoegen, Armin Giese, Barbara Angele, Hans-Walter Pfister, Uwe Koedel and Matthias Klein

    Citation: Journal of Neuroinflammation 2011 8:7

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  28. Content type: Research

    We have previously reported that inhibition of astrocytic activation contributes to the analgesic effects of intrathecal ketamine on spinal nerve ligation (SNL)-induced neuropathic pain. However, the underlyin...

    Authors: Xiao-Peng Mei, Hui Zhang, Wei Wang, Yan-Yan Wei, Ming-Zhu Zhai, Wen Wang, Li-Xian Xu and Yun-Qing Li

    Citation: Journal of Neuroinflammation 2011 8:6

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  29. Content type: Research

    The phytocannabinoid cannabidiol (CBD) exhibits antioxidant and antiinflammatory properties. The present study was designed to explore its effects in a mouse model of sepsis-related encephalitis by intravenous...

    Authors: Lourdes Ruiz-Valdepeñas, José A Martínez-Orgado, Cristina Benito, África Millán, Rosa M Tolón and Julián Romero

    Citation: Journal of Neuroinflammation 2011 8:5

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  30. Content type: Research

    Complement proteins and activation products have been found associated with neuropathology in Alzheimer's disease (AD). Recently, a C5a receptor antagonist was shown to suppress neuropathology in two murine mo...

    Authors: Maria I Fonseca, Shu-Hui Chu, Alisia M Berci, Marie E Benoit, Douglas G Peters, Yuko Kimura and Andrea J Tenner

    Citation: Journal of Neuroinflammation 2011 8:4

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  31. Content type: Research

    β-Amyloid peptide (Aβ) is a major protein in the brain associated with Alzheimer's and Parkinson's diseases. The purpose of this study was to investigate the role of macrophage antigen-1 (MAC1) receptor, an in...

    Authors: Dan Zhang, Xiaoming Hu, Li Qian, Shih-Heng Chen, Hui Zhou, Belinda Wilson, David S Miller and Jau-Shyong Hong

    Citation: Journal of Neuroinflammation 2011 8:3

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  32. Content type: Short report

    The plasmacytoid dendritic cells (pDCs) express a high level of Toll-like receptor 9 (TLR-9), which recognizes viral DNA. Activated via TLR-9, pDCs also secrete large amounts of type I interferon which are inv...

    Authors: Ana Leda F Longhini, Felipe von Glehn, Carlos Otávio Brandão, Rosemeire FO de Paula, Fernando Pradella, Adriel S Moraes, Alessandro S Farias, Elaine C Oliveira, Juan G Quispe-Cabanillas, Cassiana Horta Abreu, Alfredo Damasceno, Benito P Damasceno, Konstantin E Balashov and Leonilda MB Santos

    Citation: Journal of Neuroinflammation 2011 8:2

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  33. Content type: Research

    Reactive astrocytes are capable of producing a variety of pro-inflammatory mediators and potentially neurotoxic compounds, including nitric oxide (NO). High amounts of NO are synthesized following up-regulatio...

    Authors: Lucia Lisi, Pierluigi Navarra, Douglas L Feinstein and Cinzia Dello Russo

    Citation: Journal of Neuroinflammation 2011 8:1

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  34. Content type: Research

    Deciphering the mechanisms that modulate the inflammatory response induced by microglial activation not only improves our insight into neuroinflammation but also provides avenues for designing novel therapies ...

    Authors: Mei-Jen Wang, Hsin-Yi Huang, Wu-Fu Chen, Hui-Fen Chang and Jon-Son Kuo

    Citation: Journal of Neuroinflammation 2010 7:99

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  35. Content type: Research

    Kinin B1 receptors are inducible molecules up-regulated after inflammatory stimuli. This study evaluated the relevance of kinin B1 receptors in a mouse depression behavior model.

    Authors: Alice F Viana, Izaque S Maciel, Fabiana N Dornelles, Claudia P Figueiredo, Jarbas M Siqueira, Maria M Campos and João B Calixto

    Citation: Journal of Neuroinflammation 2010 7:98

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  36. Content type: Research

    The exact mechanism underlying HIV-associated neurocognitive disorders still remains largely unresolved. However, viral genes (for example gp120 and tat) and their effect on cytokine/chemokine expressions have be...

    Authors: Ankit Shah and Anil Kumar

    Citation: Journal of Neuroinflammation 2010 7:96

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  37. Content type: Research

    Angiogenesis is a common finding in chronic inflammatory diseases; however, its role in multiple sclerosis (MS) is unclear. Central nervous system lesions from both MS and experimental autoimmune encephalomyel...

    Authors: Timothy J Seabrook, Amanda Littlewood-Evans, Volker Brinkmann, Bernadette Pöllinger, Christian Schnell and Peter C Hiestand

    Citation: Journal of Neuroinflammation 2010 7:95

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  38. Content type: Research

    Inflammation acting in synergy with brain ischemia aggravates perinatal ischemic brain damage. The sensitizing effect of pro-inflammatory exposure prior to hypoxia is dependent on signaling by TNF-α through TN...

    Authors: Tina Markus, Stefan R Hansson, Tobias Cronberg, Corrado Cilio, Tadeusz Wieloch and David Ley

    Citation: Journal of Neuroinflammation 2010 7:94

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  39. Content type: Research

    Interactions between fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) regulate microglial activation in the CNS. Recent findings indicate that age-associated impairments in CX3CL1 and CX3CR1 are directly as...

    Authors: Angela W Corona, Yan Huang, Jason C O'Connor, Robert Dantzer, Keith W Kelley, Phillip G Popovich and Jonathan P Godbout

    Citation: Journal of Neuroinflammation 2010 7:93

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  40. Content type: Research

    Unilateral vestibular deafferentation results in strong microglial and astroglial activation in the vestibular nuclei (VN) that could be due to an inflammatory response. This study was aimed at determining if ...

    Authors: Martine Liberge, Christine Manrique, Laurence Bernard-Demanze and Michel Lacour

    Citation: Journal of Neuroinflammation 2010 7:91

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  41. Content type: Research

    Purified intravenous immunoglobulin (IVIG) obtained from the plasma of healthy humans is indicated for the treatment of primary immunodeficiency disorders associated with defects in humoral immunity. IVIG cont...

    Authors: Johanna Magga, Lakshman Puli, Rea Pihlaja, Katja Kanninen, Suvi Neulamaa, Tarja Malm, Wolfgang Härtig, Jens Grosche, Gundars Goldsteins, Heikki Tanila, Jari Koistinaho and Milla Koistinaho

    Citation: Journal of Neuroinflammation 2010 7:90

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