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  1. Heparanase, a mammalian endo-β-D-glucoronidase that specifically degrades heparan sulfate, has been implicated in inflammation and ischemic stroke. However, the role of heparanase in neuroinflammatory response...

    Authors: Benjarat Changyaleket, Zhao Zhong Chong, Randal O. Dull, Danop Nanegrungsunk and Haoliang Xu
    Citation: Journal of Neuroinflammation 2017 14:137
  2. The closely related herpes simplex viruses 1 and 2 can cause inflammations of the central nervous system (CNS), where type 1 most often manifest as encephalitis (HSE), and type 2 as meningitis (HSM). HSE is as...

    Authors: Liza Lind, Marie Studahl, Linn Persson Berg and Kristina Eriksson
    Citation: Journal of Neuroinflammation 2017 14:134
  3. During acute infections and chronic illnesses, the pro-inflammatory cytokine interleukin-1β (IL-1β) acts within the brain to elicit metabolic derangements and sickness behaviors. It is unknown which cells in t...

    Authors: Stephanie M. Krasnow, J. Gabriel Knoll, Santhosh Chakkaramakkil Verghese, Peter R. Levasseur and Daniel L. Marks
    Citation: Journal of Neuroinflammation 2017 14:133
  4. Controlling thrombin-driven microglial activation may serve as a therapeutic target for intracerebral hemorrhage (ICH). Here, we investigated microRNA (miRNA)-based regulation of thrombin-driven microglial act...

    Authors: Min Yin, Zhiying Chen, Yetong Ouyang, Huiyan Zhang, Zhigang Wan, Han Wang, Wei Wu and Xiaoping Yin
    Citation: Journal of Neuroinflammation 2017 14:132
  5. The cause of neurodegeneration in progressive forms of multiple sclerosis is unknown. We investigated the impact of specific neuroinflammatory markers on human neurons to identify potential therapeutic targets...

    Authors: Paul R. Lee, Tory P. Johnson, Sharmilee Gnanapavan, Gavin Giovannoni, Tongguang Wang, Joseph P. Steiner, Marie Medynets, Mark J. Vaal, Valerie Gartner and Avindra Nath
    Citation: Journal of Neuroinflammation 2017 14:131
  6. The endogenously produced gaseous molecule carbon monoxide is able to promote organ protection after ischemia-reperfusion injuries (IRI). The impact of carbon monoxide releasing molecules (CORM) regarding infl...

    Authors: Felix Ulbrich, Claus Hagmann, Hartmut Buerkle, Carlos C. Romao, Nils Schallner, Ulrich Goebel and Julia Biermann
    Citation: Journal of Neuroinflammation 2017 14:130
  7. Recent evidence indicates the importance of innate immunity and neuroinflammation with microgliosis in amyotrophic lateral sclerosis (ALS) pathology. The MCP1 (monocyte chemoattractant protein-1) and CCR2 (CC ...

    Authors: Javier H. Jara, Barış Genç, Macdonell J. Stanford, Peter Pytel, Raymond P. Roos, Sandra Weintraub, M. Marsel Mesulam, Eileen H. Bigio, Richard J. Miller and P. Hande Özdinler
    Citation: Journal of Neuroinflammation 2017 14:129
  8. Kv1.3 potassium channels regulate microglial functions and are overexpressed in neuroinflammatory diseases. Kv1.3 blockade may selectively inhibit pro-inflammatory microglia in neurological diseases but the mo...

    Authors: Srikant Rangaraju, Syed Ali Raza, Andrea Pennati, Qiudong Deng, Eric B. Dammer, Duc Duong, Michael W. Pennington, Malu G. Tansey, James J. Lah, Ranjita Betarbet, Nicholas T. Seyfried and Allan I. Levey
    Citation: Journal of Neuroinflammation 2017 14:128
  9. Host factors determining the clinical presentation of tick-borne encephalitis (TBE) are not fully elucidated. The peripheral inflammatory response to TBE virus is hypothesized to facilitate its entry into cent...

    Authors: Sambor Grygorczuk, Miłosz Parczewski, Renata Świerzbińska, Piotr Czupryna, Anna Moniuszko, Justyna Dunaj, Maciej Kondrusik and Sławomir Pancewicz
    Citation: Journal of Neuroinflammation 2017 14:126
  10. All known biological functions of the pro-inflammatory cytokine interleukin-1β (IL-1β) are mediated by type 1 interleukin receptor (IL-1R1). IL-1β–IL-1R1 signaling modulates various neuronal functions includin...

    Authors: Krisztina Holló, László Ducza, Zoltán Hegyi, Klaudia Dócs, Krisztina Hegedűs, Erzsébet Bakk, Ildikó Papp, Gréta Kis, Zoltán Mészár, Zsuzsanna Bardóczi and Miklós Antal
    Citation: Journal of Neuroinflammation 2017 14:125
  11. Herpes simplex virus 1 (HSV-1) infection can result in a life-threatening condition known as herpes simplex encephalitis (HSE). Trafficking patterns by which the virus reaches the central nervous system (CNS) ...

    Authors: Chandra M. Menendez and Daniel J. J. Carr
    Citation: Journal of Neuroinflammation 2017 14:124
  12. Autoantibodies, in particular those against aquaporin-4 and myelin-oligodendrocyte glycoprotein (MOG), aid as biomarkers in the differential diagnosis of demyelination. Here, we report on discovery of autoanti...

    Authors: S. Hahn, G. Trendelenburg, M. Scharf, Y. Denno, S. Brakopp, B. Teegen, C. Probst, K. P. Wandinger, M. Buttmann, A. Haarmann, F. Szabados, M. vom Dahl, T. Kümpfel, P. Eichhorn, H. Gold, F. Paul…
    Citation: Journal of Neuroinflammation 2017 14:123
  13. Blood–brain barrier (BBB) breakdown and inflammation are critical events in ischemic stroke, contributing to aggravated brain damage. The BBB mainly consists of microvascular endothelial cells sealed by tight ...

    Authors: Haiying Zhang, Joon Ha Park, Sony Maharjan, Jeong Ae Park, Kyu-Sung Choi, Hyojin Park, Yoonjeong Jeong, Ji Hyeon Ahn, In Hye Kim, Jae-Chul Lee, Jeong Hwi Cho, In-Kyu Lee, Choong Hyun Lee, In Koo Hwang, Young-Myeong Kim, Young-Ger Suh…
    Citation: Journal of Neuroinflammation 2017 14:122
  14. Retinal detachment (RD) can lead to proliferative vitreoretinopathy (PVR), a leading cause of intractable vision loss. PVR is associated with a cytokine storm involving common proinflammatory molecules like IL...

    Authors: Xinlei Wang, Eric B. Miller, Mayank Goswami, Pengfei Zhang, Kaitryn E. Ronning, Sarah J. Karlen, Robert J. Zawadzki, Edward N. Pugh Jr. and Marie E. Burns
    Citation: Journal of Neuroinflammation 2017 14:121
  15. Natural IgM antibodies (Abs) function as innate immune sensors of injury via recognition of neoepitopes expressed on damaged cells, although how this recognition systems function following spinal cord injury (...

    Authors: Aarti Narang, Fei Qiao, Carl Atkinson, Hong Zhu, Xiaofeng Yang, Liudmila Kulik, V. Michael Holers and Stephen Tomlinson
    Citation: Journal of Neuroinflammation 2017 14:120
  16. Intracerebral hemorrhage (ICH) induces potently oxidative stress responses and inflammatory processes. Isoliquiritigenin (ILG) is a flavonoid with a chalcone structure and can activate nuclear factor erythroid...

    Authors: Jun Zeng, Yizhao Chen, Rui Ding, Liang Feng, Zhenghao Fu, Shuo Yang, Xinqing Deng, Zhichong Xie and Shizhong Zheng
    Citation: Journal of Neuroinflammation 2017 14:119
  17. The innate immune system is known to be involved early in the pathogenesis of Alzheimer’s disease (AD) and other neurodegenerative disorders. The inflammatory response in the central nervous system can be meas...

    Authors: Marta Querol-Vilaseca, Martí Colom-Cadena, Jordi Pegueroles, Carla San Martín-Paniello, Jordi Clarimon, Olivia Belbin, Juan Fortea and Alberto Lleó
    Citation: Journal of Neuroinflammation 2017 14:118
  18. Multiple sclerosis (MS) is a chronic debilitating disease of the central nervous system primarily mediated by T lymphocytes with specificity to neuronal antigens in genetically susceptible individuals. On the ...

    Authors: K. M. Danikowski, S. Jayaraman and B. S. Prabhakar
    Citation: Journal of Neuroinflammation 2017 14:117
  19. Chronic microglia-mediated inflammation and oxidative stress are well-characterized underlying factors in neurodegenerative disease, whereby reactive inflammatory microglia enhance ROS production and impact ne...

    Authors: S. D. Benusa, N. M. George, B. A. Sword, G. H. DeVries and J. L. Dupree
    Citation: Journal of Neuroinflammation 2017 14:116
  20. Increasing evidence supports a key role for inflammation in the neurodegenerative process of familial amyloidotic polyneuropathy (FAP). While there seems to be an overactivation of the neuronal interleukin-1 s...

    Authors: Nádia Pereira Gonçalves, João Moreira, Diana Martins, Paulo Vieira, Laura Obici, Giampaolo Merlini, Margarida Saraiva and Maria João Saraiva
    Citation: Journal of Neuroinflammation 2017 14:115
  21. Cerebral microbleeds (CMB) are MRI-demonstrable cerebral microhemorrhages (CMH) which commonly coexist with ischemic stroke. This creates a challenging therapeutic milieu, and a strategy that simultaneously pr...

    Authors: Rachita K. Sumbria, Vitaly Vasilevko, Mher Mahoney Grigoryan, Annlia Paganini-Hill, Ronald Kim, David H. Cribbs and Mark J. Fisher
    Citation: Journal of Neuroinflammation 2017 14:114
  22. Autism spectrum disorder (ASD) affects approximately 1 in 68 children in the USA. An ASD blood biomarker may enable early diagnosis and/or identification of new therapeutic targets. Serum samples from ASD and ...

    Authors: Sarika Singh, Umar Yazdani, Bharathi Gadad, Sayed Zaman, Linda S. Hynan, Nichole Roatch, Claire Schutte, C. Nathan Marti, Laura Hewitson and Dwight C. German
    Citation: Journal of Neuroinflammation 2017 14:113
  23. Lymphocytes have been shown to play an important role in the pathophysiology of acute ischemic stroke, but the properties of B cells remain controversial. The aim of this study was to unravel the role of B cel...

    Authors: Michael K. Schuhmann, Friederike Langhauser, Peter Kraft and Christoph Kleinschnitz
    Citation: Journal of Neuroinflammation 2017 14:112
  24. Sphingosine 1-phosphate (S1P) signals through G protein-coupled receptors to elicit a wide range of cellular responses. In CNS injury and disease, the blood-brain barrier is compromised, causing leakage of S1P...

    Authors: Stephanie S. Dusaban, Jerold Chun, Hugh Rosen, Nicole H. Purcell and Joan Heller Brown
    Citation: Journal of Neuroinflammation 2017 14:111
  25. In previous studies, human oligodendrocytes were demonstrated to undergo apoptosis in the presence of Borrelia burgdorferi under an inflammatory milieu. Subsequently, we determined that the MEK/ERK pathway played...

    Authors: Geetha Parthasarathy and Mario T. Philipp
    Citation: Journal of Neuroinflammation 2017 14:110
  26. Microglia, as well as other tissue-resident macrophages, arise from yolk sac progenitors. Thus, it is likely that the central nervous system environment is critical for the acquisition of a distinct microglial...

    Authors: Reiko Saika, Hiroshi Sakuma, Daisuke Noto, Shuhei Yamaguchi, Takashi Yamamura and Sachiko Miyake
    Citation: Journal of Neuroinflammation 2017 14:109
  27. Chronic subdural haematoma (CSDH) is an encapsulated collection of blood and fluid on the surface of the brain. Historically considered a result of head trauma, recent evidence suggests there are more complex ...

    Authors: Ellie Edlmann, Susan Giorgi-Coll, Peter C. Whitfield, Keri L. H. Carpenter and Peter J. Hutchinson
    Citation: Journal of Neuroinflammation 2017 14:108
  28. Polyglutamine (polyQ) expansion in the protein Ataxin-1 (ATXN1) causes spinocerebellar ataxia type 1 (SCA1), a fatal dominantly inherited neurodegenerative disease characterized by motor deficits, cerebellar n...

    Authors: Wenhui Qu, Andrea Johnson, Joo Hyun Kim, Abigail Lukowicz, Daniel Svedberg and Marija Cvetanovic
    Citation: Journal of Neuroinflammation 2017 14:107
  29. The cellular prion protein (PrPC) is an evolutionary conserved protein abundantly expressed not only in the central nervous system but also peripherally including the immune system. A line of Norwegian dairy goat...

    Authors: Ø. Salvesen, M. R. Reiten, A. Espenes, M. K. Bakkebø, M. A. Tranulis and C. Ersdal
    Citation: Journal of Neuroinflammation 2017 14:106
  30. The influx of leukocytes into the central nervous system (CNS) is a key hallmark of the chronic neuro-inflammatory disease multiple sclerosis (MS). Strategies that aim to inhibit leukocyte migration across the...

    Authors: Suzanne A. B. M. Aarts, Tom T. P. Seijkens, Pascal J. H. Kusters, Susanne M. A. van der Pol, Barbara Zarzycka, Priscilla D. A. M. Heijnen, Linda Beckers, Myrthe den Toom, Marion J. J. Gijbels, Louis Boon, Christian Weber, Helga E. de Vries, Gerry A. F. Nicolaes, Christine D. Dijkstra, Gijs Kooij and Esther Lutgens
    Citation: Journal of Neuroinflammation 2017 14:105
  31. Early brain injury (EBI) is considered a major contributor to the high morbidity and mortality associated with subarachnoid haemorrhage (SAH). Both of sterile inflammation and apoptosis are considered the impo...

    Authors: Qing Zhao, Xudong Che, Hongxia Zhang, Pianpian Fan, Guanping Tan, Liu Liu, Dengzhi Jiang, Jun Zhao, Xiang Xiang, Yidan Liang, Xiaochuan Sun and Zhaohui He
    Citation: Journal of Neuroinflammation 2017 14:104
  32. Hypomethylation of the cathepsin Z locus has been proposed as an epigenetic risk factor for multiple sclerosis (MS). Cathepsin Z is a unique lysosomal cysteine cathepsin expressed primarily by antigen presenti...

    Authors: Euan R. O. Allan, Rhiannon I. Campden, Benjamin W. Ewanchuk, Pankaj Tailor, Dale R. Balce, Neil T. McKenna, Catherine J. Greene, Amy L. Warren, Thomas Reinheckel and Robin M. Yates
    Citation: Journal of Neuroinflammation 2017 14:103
  33. In recent years, proinflammatory cytokine interleukin-1β (IL-1β) was considered to play a critical role in the pathogenesis of depression. In addition, P2X7 receptor (P2X7R), a member of the purinergic recepto...

    Authors: Na Yue, Huijie Huang, Xiaocang Zhu, Qiuqin Han, Yalin Wang, Bing Li, Qiong Liu, Gencheng Wu, Yuqiu Zhang and Jin Yu
    Citation: Journal of Neuroinflammation 2017 14:102
  34. Authors: Jagadeesh Sridhara Rao, Hyung-Wook Kim, Matthew Kellom, Dede Greenstein, Mei Chen, Andrew David Kraft, Gaylia Jean Harry, Stanley Isaac Rapoport and Mireille Basselin
    Citation: Journal of Neuroinflammation 2017 14:95

    The original article was published in Journal of Neuroinflammation 2011 8:101

  35. Microglial cultures comprise a critically important model system for investigating inflammatory mechanisms in almost all CNS disorders. Mild trypsinization and shaking are the two most commonly used methods to...

    Authors: Li Lin, Rakhi Desai, Xiaoying Wang, Eng H. Lo and Changhong Xing
    Citation: Journal of Neuroinflammation 2017 14:101
  36. One of the main challenges in treating multiple sclerosis (MS) is reversing the effects of accumulated damage in the central nervous system (CNS) of progressive MS subjects. While most of the available drugs f...

    Authors: Gil Benedek, Priya Chaudhary, Roberto Meza-Romero, Evan Calkins, Gail Kent, Halina Offner, Dennis Bourdette and Arthur A. Vandenbark
    Citation: Journal of Neuroinflammation 2017 14:100
  37. As the primary immune response cell in the central nervous system, microglia constantly monitor the microenvironment and respond rapidly to stress, infection, and injury, making them important modulators of ne...

    Authors: Kelly S. Kirkley, Katriana A. Popichak, Maryam F. Afzali, Marie E. Legare and Ronald B. Tjalkens
    Citation: Journal of Neuroinflammation 2017 14:99
  38. Kososan, a Kampo (traditional Japanese herbal) medicine, has been used for the therapy of depressive mood in humans. However, evidence for the antidepressant efficacy of kososan and potential mechanisms are la...

    Authors: Naoki Ito, Eiji Hirose, Tatsuya Ishida, Atsushi Hori, Takayuki Nagai, Yoshinori Kobayashi, Hiroaki Kiyohara, Tetsuro Oikawa, Toshihiko Hanawa and Hiroshi Odaguchi
    Citation: Journal of Neuroinflammation 2017 14:98
  39. Hydroxysafflor yellow A (HSYA) is a major active component of yellow pigment extracted from safflowers; this compound possesses potent neuroprotective effects both in vitro and in vivo. However, underlying mec...

    Authors: Jun-peng Pei, Li-hong Fan, Kai Nan, Jia Li, Xiao-qian Dang and Kun-zheng Wang
    Citation: Journal of Neuroinflammation 2017 14:97
  40. Age is the primary risk factor for many diseases. As such, age is a critical co-factor for examination in order to understand the progression and potential intervention in disease progression. Studies examinin...

    Authors: Antwoine Flowers, Harris Bell-Temin, Ahmad Jalloh, Stanley M. Stevens Jr. and Paula C. Bickford
    Citation: Journal of Neuroinflammation 2017 14:96
  41. Ginkgo biloba has been reported to possess free radical-scavenging antioxidant activity and anti-inflammatory properties. In our pilot study, YY-1224, a terpene trilactone-strengthened...

    Authors: Zheng-Yi Li, Yoon Hee Chung, Eun-Joo Shin, Duy-Khanh Dang, Ji Hoon Jeong, Sung Kwon Ko, Seung-Yeol Nah, Tae Gon Baik, Jin Hyeong Jhoo, Wei-Yi Ong, Toshitaka Nabeshima and Hyoung-Chun Kim
    Citation: Journal of Neuroinflammation 2017 14:94
  42. We previously reported a profound long-term neuroprotection subsequent to a single radiation-therapy in the DBA/2J mouse model of glaucoma. This neuroprotection prevents entry of monocyte-like immune cells int...

    Authors: Pete A. Williams, Catherine E. Braine, Nicole E. Foxworth, Kelly E. Cochran and Simon W. M. John
    Citation: Journal of Neuroinflammation 2017 14:93
  43. Fingolimod, a sphingosine-1-phosphate receptor modulator with well-described immunomodulatory properties involving peripheral immune cell trafficking, was the first oral agent approved for the treatment of rel...

    Authors: Björn Ambrosius, Kalliopi Pitarokoili, Lisa Schrewe, Xiomara Pedreiturria, Jeremias Motte and Ralf Gold
    Citation: Journal of Neuroinflammation 2017 14:92
  44. The consumption of large amounts of dietary fats is one of the most important environmental factors contributing to the development of obesity and metabolic disorders. GPR120 and GPR40 are polyunsaturated fatt...

    Authors: Nathalia R. V. Dragano, Carina Solon, Albina F. Ramalho, Rodrigo F. de Moura, Daniela S. Razolli, Elisabeth Christiansen, Carlos Azevedo, Trond Ulven and Licio A. Velloso
    Citation: Journal of Neuroinflammation 2017 14:91
  45. Despite previous evidence for a potent inflammatory response after a traumatic brain injury (TBI), it is unknown whether exercise preconditioning (EP) improves outcomes after a TBI by modulating inflammatory r...

    Authors: Chung-Ching Chio, Hung-Jung Lin, Yu-Feng Tian, Yu-Chieh Chen, Mao-Tsun Lin, Cheng-Hsien Lin, Ching-Ping Chang and Chien-Chin Hsu
    Citation: Journal of Neuroinflammation 2017 14:90
  46. The pathology of multiple system atrophy cerebellar-type (MSA-C) includes glial inflammation; however, cerebrospinal fluid (CSF) inflammatory cytokine profiles have not been investigated. In this study, we det...

    Authors: Ryo Yamasaki, Hiroo Yamaguchi, Takuya Matsushita, Takayuki Fujii, Akio Hiwatashi and Jun-ichi Kira
    Citation: Journal of Neuroinflammation 2017 14:89
  47. The majority of Parkinson’s disease (PD) cases are sporadic and idiopathic suggesting that this neurodegenerative disorder is the result of both environmental and genetic factors. Stress and neuroinflammation ...

    Authors: Simone Mori, Shuei Sugama, William Nguyen, Tatiana Michel, M. Germana Sanna, Manuel Sanchez-Alavez, Rigo Cintron-Colon, Gianluca Moroncini, Yoshihiko Kakinuma, Pamela Maher and Bruno Conti
    Citation: Journal of Neuroinflammation 2017 14:88

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