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  1. Content type: Research

    Current evidence suggests a role of neuroinflammation in the pathogenesis of Parkinson's disease (PD) and in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of basal ganglia injury. Reportedly, n...

    Authors: Francesca L'Episcopo, Cataldo Tirolo, Salvatore Caniglia, Nunzio Testa, Pier A Serra, Francesco Impagnatiello, Maria C Morale and Bianca Marchetti

    Citation: Journal of Neuroinflammation 2010 7:83

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  2. Content type: Research

    Methamphetamine (MA) use is associated with activation of microglia and, at high doses, can induce neurotoxicity. Given the changes in the neuroinflammatory environment associated with MA, we investigated whet...

    Authors: Jessica B Buchanan, Nathan L Sparkman and Rodney W Johnson

    Citation: Journal of Neuroinflammation 2010 7:82

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  3. Content type: Short report

    Under certain experimental conditions, neurotrophic factors may reduce epileptogenesis. We have previously reported that local, intrahippocampal supplementation of fibroblast growth factor-2 (FGF-2) and brain-...

    Authors: Roberta Bovolenta, Silvia Zucchini, Beatrice Paradiso, Donata Rodi, Flavia Merigo, Graciela Navarro Mora, Francesco Osculati, Elena Berto, Peggy Marconi, Andrea Marzola, Paolo F Fabene and Michele Simonato

    Citation: Journal of Neuroinflammation 2010 7:81

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  4. Content type: Short report

    Autism spectrum disorders (ASD) are neurodevelopmental disorders characterized by difficulties in communication, cognitive and learning deficits, as well as stereotypic behaviors. For the majority of cases the...

    Authors: Bodi Zhang, Asimenia Angelidou, Konstantinos-Dionysios Alysandratos, Magdalini Vasiadi, Konstantinos Francis, Shahrzad Asadi, Athanasios Theoharides, Kyriaki Sideri, Lefteris Lykouras, Dimitrios Kalogeromitros and Theoharis C Theoharides

    Citation: Journal of Neuroinflammation 2010 7:80

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  5. Content type: Research

    Neuroinflammation and demyelination have been suggested as mechanisms causing HIV-1 associated neurocognitive disorder (HAND). This cross-sectional cohort study explores the potential role of antibodies to mye...

    Authors: Peter Lackner, Bettina Kuenz, Markus Reindl, Maria Morandell, Thomas Berger, Erich Schmutzhard and Christian Eggers

    Citation: Journal of Neuroinflammation 2010 7:79

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  6. Content type: Research

    Numerous studies have reported that increased expression of S100B, an intracellular Ca2+ receptor protein and secreted neuropeptide, exacerbates Alzheimer's disease (AD) pathology. However, the ability of S100B i...

    Authors: Emily Roltsch, Leigh Holcomb, Keith A Young, Alexander Marks and Danna B Zimmer

    Citation: Journal of Neuroinflammation 2010 7:78

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  7. Content type: Research

    Interferon gamma (IFNγ) is a pro-inflammatory cytokine, which may be up-regulated after trauma to the peripheral or central nervous system. Such changes include reactive gliosis and synaptic plasticity that ar...

    Authors: Sheila CS Victório, Leif A Havton and Alexandre LR Oliveira

    Citation: Journal of Neuroinflammation 2010 7:77

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  8. Content type: Case study

    The contribution of inflammation to neurodegenerative diseases is increasingly recognized, but the role of inflammation in sporadic amyotrophic lateral sclerosis (sALS) is not well understood and no animal mod...

    Authors: Milan Fiala, Madhuri Chattopadhay, Antonio La Cava, Eric Tse, Guanghao Liu, Elaine Lourenco, Ascia Eskin, Philip T Liu, Larry Magpantay, Stephen Tse, Michelle Mahanian, Rachel Weitzman, Jason Tong, Caroline Nguyen, Tiffany Cho, Patrick Koo…

    Citation: Journal of Neuroinflammation 2010 7:76

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  9. Content type: Research

    Recombinant T cell receptor ligands (RTLs) are bio-engineered molecules that may serve as novel therapeutic agents for the treatment of neuroinflammatory conditions such as multiple sclerosis (MS). RTLs contai...

    Authors: Asako Itakura, Joseph E Aslan, Sushmita Sinha, Tara C White-Adams, Ishan A Patel, Roberto Meza-Romero, Arthur A Vandenbark, Gregory G Burrows, Halina Offner and Owen JT McCarty

    Citation: Journal of Neuroinflammation 2010 7:75

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  10. Content type: Review

    Neuroinflammation is a key element in the ischemic cascade after cerebral ischemia that results in cell damage and death in the subacute phase. However, anti-inflammatory drugs do not improve outcome in clinic...

    Authors: An-Gaëlle Ceulemans, Tine Zgavc, Ron Kooijman, Said Hachimi-Idrissi, Sophie Sarre and Yvette Michotte

    Citation: Journal of Neuroinflammation 2010 7:74

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  11. Content type: Research

    WNV-associated encephalitis (WNVE) is characterized by increased production of pro-inflammatory mediators, glial cells activation and eventual loss of neurons. WNV infection of neurons is rapidly progressive a...

    Authors: Mukesh Kumar, Saguna Verma and Vivek R Nerurkar

    Citation: Journal of Neuroinflammation 2010 7:73

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  12. Content type: Research

    This study compared the level of advanced glycation end products (AGEs), N-(Carboxymethyl)lysine (CML) and N-(Carboxyethyl)lysine (CEL), in patients with multiple sclerosis (MS) and healthy controls (HCs), correl...

    Authors: Zohara Sternberg, Cassandra Hennies, Daniel Sternberg, Ping Wang, Peter Kinkel, David Hojnacki, Bianca Weinstock-Guttmann and Frederick Munschauer

    Citation: Journal of Neuroinflammation 2010 7:72

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  13. Content type: Research

    Vascular dysfunction and brain inflammation are thought to contribute to the pathophysiology of cerebral injury in acute stroke. However acute inflammation and vascular dysfunction may simply be markers of an ...

    Authors: Christopher Beer, David Blacker, Michael Bynevelt, Graeme J Hankey and Ian B Puddey

    Citation: Journal of Neuroinflammation 2010 7:71

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  14. Content type: Research

    Circumventricular organs (CVO) are cerebral areas with incomplete endothelial blood-brain barrier (BBB) and therefore regarded as "gates to the brain". During inflammation, they may exert an active role in det...

    Authors: Eva Wuerfel, Carmen Infante-Duarte, Robert Glumm and Jens T Wuerfel

    Citation: Journal of Neuroinflammation 2010 7:70

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  15. Content type: Research

    Amyotrophic lateral sclerosis (ALS) is a disease affecting the central nervous system that is either sporadic or familial origin and causing the death of motor neurons. One of the genetic factors contributing ...

    Authors: Eun Jin Yang, Jing Hua Jiang, Sang Min Lee, Sun Choel Yang, Hye Suk Hwang, Myeong Soo Lee and Sun-Mi Choi

    Citation: Journal of Neuroinflammation 2010 7:69

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  16. Content type: Research

    Activation of microglia, the resident macrophages of the central nervous system (CNS), is the hallmark of neuroinflammation in neurodegenerative diseases and other pathological conditions associated with CNS i...

    Authors: Deepak K Kaushik, Malvika Gupta, Sulagna Das and Anirban Basu

    Citation: Journal of Neuroinflammation 2010 7:68

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  17. Content type: Research

    The chemokine CCL2 (also known as monocyte chemoattractant protein-1, or MCP-1) is upregulated in patients and rodent models of traumatic brain injury (TBI), contributing to post-traumatic neuroinflammation an...

    Authors: Bridgette D Semple, Tony Frugier and M Cristina Morganti-Kossmann

    Citation: Journal of Neuroinflammation 2010 7:67

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  18. Content type: Research

    Brain edema leading to high intracranial pressure is a lethal complication of acute liver failure (ALF), which is believed to be cytotoxic due to swelling of astrocytes. In addition to the traditional view tha...

    Authors: Kakulavarapu V Rama Rao, Arumugam R Jayakumar, Xiaoying Tong, Veronica M Alvarez and Michael D Norenberg

    Citation: Journal of Neuroinflammation 2010 7:66

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  19. Content type: Research

    Numerous epidemiological studies demonstrate that genetic background modifies the onset and the progression of Alzheimer's disease and related neurodegenerative disorders. The efficacious influence of genetic ...

    Authors: Zuzana Stozicka, Norbert Zilka, Petr Novak, Branislav Kovacech, Ondrej Bugos and Michal Novak

    Citation: Journal of Neuroinflammation 2010 7:64

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  20. Content type: Research

    Most neurodegenerative diseases are age-related disorders; however, how aging predisposes the brain to disease has not been adequately addressed. The objective of this study is to determine whether expression ...

    Authors: Debjani Tripathy, Xiangling Yin, Alma Sanchez, Jinhua Luo, Joseph Martinez and Paula Grammas

    Citation: Journal of Neuroinflammation 2010 7:63

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  21. Content type: Research

    TGFβ is both neuroprotective and a key immune system modulator and is likely to be an important target for future stroke therapy. The precise function of increased TGF-β1 after stroke is unknown and its pleiot...

    Authors: Kristian P Doyle, Egle Cekanaviciute, Lauren E Mamer and Marion S Buckwalter

    Citation: Journal of Neuroinflammation 2010 7:62

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  22. Content type: Research

    Microglial activation plays an integral role in the development and course of neurodegeneration. Although neuropeptides such as bradykinin (BK), somatostatin (SST), and endothelin (ET) are known to be importan...

    Authors: Sigal Fleisher-Berkovich, Talia Filipovich-Rimon, Sarit Ben-Shmuel, Claudia Hülsmann, Markus P Kummer and Michael T Heneka

    Citation: Journal of Neuroinflammation 2010 7:61

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  23. Content type: Research

    Multiple sclerosis (MS) is the endpoint of a complex and still poorly understood process which results in inflammation, demyelination and axonal and neuronal degeneration. Since the first description of MS, ps...

    Authors: Beatriz G Pérez-Nievas, Borja García-Bueno, José LM Madrigal and Juan C Leza

    Citation: Journal of Neuroinflammation 2010 7:60

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  24. Content type: Research

    The classic neuritic β-amyloid plaque of Alzheimer's disease (AD) is typically associated with activated microglia and neuroinflammation. Similarly, cerebrovascular β-amyloid (Aβ) deposits are surrounded by pe...

    Authors: Philipp Spitzer, Martin Herrmann, Hans-Wolfgang Klafki, Alexander Smirnov, Piotr Lewczuk, Johannes Kornhuber, Jens Wiltfang and Juan Manuel Maler

    Citation: Journal of Neuroinflammation 2010 7:59

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  25. Content type: Research

    Passive immunization with antibodies directed to Aβ decreases brain Aβ/amyloid burden and preserves memory in transgenic mouse models of Alzheimer's disease (AD). This therapeutic strategy is under intense scr...

    Authors: S Sakura Minami, Elkhansa Sidahmed, Saba Aid, Mika Shimoji, Takako Niikura, Italo Mocchetti, G William Rebeck, Jay S Prendergast, Chris Dealwis, Ronald Wetzel, Francesca Bosetti, Yasuji Matsuoka, Hyang-Sook Hoe and R Scott Turner

    Citation: Journal of Neuroinflammation 2010 7:57

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  26. Content type: Research

    Inflammation and microglial activation are associated with Alzheimer's disease (AD) pathology. Somewhat surprisingly, injection of a prototypical inflammatory agent, lipopolysaccharide (LPS) into brains of amy...

    Authors: Daniel C Lee, Justin Rizer, Maj-Linda B Selenica, Patrick Reid, Clara Kraft, Amelia Johnson, Laura Blair, Marcia N Gordon, Chad A Dickey and Dave Morgan

    Citation: Journal of Neuroinflammation 2010 7:56

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  27. Content type: Research

    Recent studies have demonstrated an inflammatory response associated with the pathophysiology of cerebral ischemia. The beneficial effects of anti-inflammatory drugs in cerebral ischemia have been documented. ...

    Authors: Wanglin Jiang, Shuping Zhang, Fenghua Fu, Haibo Zhu and Jian Hou

    Citation: Journal of Neuroinflammation 2010 7:55

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  28. Content type: Research

    In several neuropathological conditions, microglia can become overactivated and cause neurotoxicity by initiating neuronal damage in response to pro-inflammatory stimuli. Our previous studies have shown that e...

    Authors: Xuesen Yang, Genlin He, Yutong Hao, Chunhai Chen, Maoquan Li, Yuan Wang, Guangbin Zhang and Zhengping Yu

    Citation: Journal of Neuroinflammation 2010 7:54

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  29. Content type: Research

    Neuroinflammation is a complex process involving cells from the immune system and the central nerve system (CNS). Polymorphonuclear neutrophils (PMN) are the most abundant class of white blood cells, and typic...

    Authors: Luokun Xie, Ethan C Poteet, Wenjun Li, Amanda E Scott, Ran Liu, Yi Wen, Anuja Ghorpade, James W Simpkins and Shao-Hua Yang

    Citation: Journal of Neuroinflammation 2010 7:53

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  30. Content type: Research

    In 70-80% of cases, neuromyelitis optica (NMO) is associated with highly specific serum auto-antibodies to aquaporin-4 (termed AQP4-Ab or NMO-IgG). Recent evidence strongly suggests that AQP4-Ab are directly i...

    Authors: Sven Jarius, Diego Franciotta, Friedemann Paul, Klemens Ruprecht, Roberto Bergamaschi, Paulus S Rommer, Reinhard Reuss, Christian Probst, Wolfgang Kristoferitsch, Klaus Peter Wandinger and Brigitte Wildemann

    Citation: Journal of Neuroinflammation 2010 7:52

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  31. Content type: Research

    Heme oxygenase (HO)-1 has been shown to attenuate oxidative injury and reduce apoptosis. HO-1 can be induced by various stimuli released during cellular injury, such as heme. Deleterious free heme is degraded ...

    Authors: Wen S Sheng, Shuxian Hu, Adam R Nettles, James R Lokensgard, Gregory M Vercellotti and R Bryan Rock

    Citation: Journal of Neuroinflammation 2010 7:51

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  32. Content type: Research

    Neuromyelitis optica spectrum disorders (NMOSD) are severe central nervous system inflammatory demyelinating disorders (CNS IDD) characterized by monophasic or relapsing, longitudinally extensive transverse my...

    Authors: Koon H Chan, Jason SC Kwan, Philip WL Ho, Jessica WM Ho, Andrew CY Chu and David B Ramsden

    Citation: Journal of Neuroinflammation 2010 7:50

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  33. Content type: Short report

    Autism spectrum disorders (ASD) are a group of pervasive neurodevelopmental disorders diagnosed in early childhood. They are associated with a set of "core symptoms" that include disabilities in social interac...

    Authors: Asimenia Angelidou, Konstantinos Francis, Magdalini Vasiadi, Konstantinos-Dionysios Alysandratos, Bodi Zhang, Athanasios Theoharides, Lefteris Lykouras, Kyriaki Sideri, Dimitrios Kalogeromitros and Theoharis C Theoharides

    Citation: Journal of Neuroinflammation 2010 7:48

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  34. Content type: Research

    Inflammatory responses in the CNS mediated by activated glial cells play an important role in host-defense but are also involved in the development of neurodegenerative diseases. Resveratrol is a natural polyp...

    Authors: Xiaofeng Lu, Lili Ma, Lingfei Ruan, Yan Kong, Haiwei Mou, Zhijie Zhang, Zhijun Wang, Ji Ming Wang and Yingying Le

    Citation: Journal of Neuroinflammation 2010 7:46

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  35. Content type: Research

    Neurodegenerative diseases are characterized by both mitochondrial dysfunction and activation of microglia, the macrophages of the brain. Here, we investigate the effects of mitochondrial dysfunction on the ac...

    Authors: Annette I Ferger, Loretta Campanelli, Valentina Reimer, Katharina N Muth, Irma Merdian, Albert C Ludolph and Anke Witting

    Citation: Journal of Neuroinflammation 2010 7:45

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  36. Content type: Research

    Transient stimulation of the innate immune system by an intraperitoneal injection of lipopolysaccharide (LPS) activates peripheral and central expression of the tryptophan degrading enzyme indoleamine 2,3 diox...

    Authors: Xin Fu, Samantha M Zunich, Jason C O'Connor, Annemieke Kavelaars, Robert Dantzer and Keith W Kelley

    Citation: Journal of Neuroinflammation 2010 7:43

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  37. Content type: Research

    The enzyme cytosolic phospholipase A2 alpha (cPLA2α) has been implicated in the progression of cerebral injury following ischemia and reperfusion. Previous studies in rodents suggest that cPLA2α enhances delayed ...

    Authors: Koji Kishimoto, Rung-Chi Li, Jian Zhang, Judith A Klaus, Kathleen K Kibler, Sylvain Doré, Raymond C Koehler and Adam Sapirstein

    Citation: Journal of Neuroinflammation 2010 7:42

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  38. Content type: Research

    We hypothesized that gp91phox (NOX2), a subunit of NADPH oxidase, generates superoxide anion (O2-) and has a major causative role in traumatic brain injury (TBI). To evaluate the functional role of gp91phox and r...

    Authors: Kenji Dohi, Hirokazu Ohtaki, Tomoya Nakamachi, Sachiko Yofu, Kazue Satoh, Kazuyuki Miyamoto, Dandan Song, Shohko Tsunawaki, Seiji Shioda and Tohru Aruga

    Citation: Journal of Neuroinflammation 2010 7:41

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  39. Content type: Research

    Neuroinflammation occurs following brain injury, including soman (GD) induced status epilepticus (SE), and may contribute to loss of neural tissue and declined behavioral function. However, little is known abo...

    Authors: Erik A Johnson and Robert K Kan

    Citation: Journal of Neuroinflammation 2010 7:40

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  40. Content type: Research

    Recently, using a mouse model of mucopolysaccharidosis (MPS) IIIB, a lysosomal storage disease with severe neurological deterioration, we showed that MPS IIIB neuropathology is accompanied by a robust neuroinf...

    Authors: Smruti Killedar, Julianne DiRosario, Erin Divers, Phillip G Popovich, Douglas M McCarty and Haiyan Fu

    Citation: Journal of Neuroinflammation 2010 7:39

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  41. Content type: Research

    A major site of initiation of inflammatory responses upon physical perturbation(s) and infection by invading organisms is the skin. Control of responses in this organ is, in part, modulated by the neuronal nic...

    Authors: Lorise C Gahring, Amber V Osborne, Michelle Reed and Scott W Rogers

    Citation: Journal of Neuroinflammation 2010 7:38

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  42. Content type: Review

    Inflammatory bowel disease is a chronic intestinal inflammatory condition, the pathology of which is incompletely understood. Gut inflammation causes significant changes in neurally controlled gut functions in...

    Authors: Shaheen E Lakhan and Annette Kirchgessner

    Citation: Journal of Neuroinflammation 2010 7:37

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  43. Content type: Research

    The pro-nociceptive kinin B1 receptor (B1R) is upregulated on sensory C-fibres, astrocytes and microglia in the spinal cord of streptozotocin (STZ)-diabetic rat. This study aims at defining the role of microglial...

    Authors: Sébastien Talbot, Emna Chahmi, Jenny Pena Dias and Réjean Couture

    Citation: Journal of Neuroinflammation 2010 7:36

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  44. Content type: Research

    Using a murine model of herpes simplex virus (HSV)-1 encephalitis, our laboratory has determined that induction of proinflammatory mediators in response to viral infection is largely mediated through a Toll-li...

    Authors: Scott J Schachtele, Shuxian Hu, Morgan R Little and James R Lokensgard

    Citation: Journal of Neuroinflammation 2010 7:35

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  45. Content type: Research

    CHI3L1 (YKL-40) is up-regulated in a variety of inflammatory conditions and cancers. We have previously reported elevated CHI3L1 concentration in the cerebrospinal fluid (CSF) of human and non-human primates w...

    Authors: Dafna Bonneh-Barkay, Guoji Wang, Adam Starkey, Ronald L Hamilton and Clayton A Wiley

    Citation: Journal of Neuroinflammation 2010 7:34

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