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  1. Content type: Review

    Inflammation of the central nervous system is an important but poorly understood part of neurological disease. After acute brain injury or infection there is a complex inflammatory response that involves activ...

    Authors: Marion S Buckwalter and Tony Wyss-Coray

    Citation: Journal of Neuroinflammation 2004 1:10

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  2. Content type: Research

    Under pathological conditions, microglia produce proinflammatory mediators which contribute to neurologic damage, and whose levels can be modulated by endogenous factors including neurotransmitters such as nor...

    Authors: Cinzia Dello Russo, Anne I Boullerne, Vitaliy Gavrilyuk and Douglas L Feinstein

    Citation: Journal of Neuroinflammation 2004 1:9

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  3. Content type: Research

    The pathogenesis of HIV-1 glycoprotein 120 (gp120) associated neuroglial toxicity remains unresolved, but oxidative injury has been widely implicated as a contributing factor. In previous studies, exposure of ...

    Authors: Kimberley A Walsh, Joseph F Megyesi, John X Wilson, Jeff Crukley, Victor E Laubach and Robert R Hammond

    Citation: Journal of Neuroinflammation 2004 1:8

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  4. Content type: Research

    Several lines of evidence point to a significant role of neuroinflammation in Parkinson's disease (PD) and other neurodegenerative disorders. In the present study we examined the protective effect of celecoxib...

    Authors: Rosario Sánchez-Pernaute, Andrew Ferree, Oliver Cooper, Meixiang Yu, Anna-Liisa Brownell and Ole Isacson

    Citation: Journal of Neuroinflammation 2004 1:6

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  5. Content type: Commentary

    Peroxisome proliferator-activated receptors (PPARs) are a class of nuclear transcription factors that are activated by fatty acids and their derivatives. One of these, PPARγ, regulates responsiveness to insuli...

    Authors: Robert E Mrak and Gary E Landreth

    Citation: Journal of Neuroinflammation 2004 1:5

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  6. Content type: Research

    Roles for excitotoxicity and inflammation in Alzheimer's disease have been hypothesized. Proinflammatory stimuli, including amyloid β-peptide (Aβ), elicit a release of glutamate from microglia. We tested the p...

    Authors: Sheng-Zhou Wu, Angela M Bodles, Mandy M Porter, W Sue T Griffin, Anthony S Basile and Steven W Barger

    Citation: Journal of Neuroinflammation 2004 1:2

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  7. Content type: Case report

    Ligands of the peroxisome proliferator-activated receptor-gamma (PPARγ) induce apoptosis in activated T-lymphocytes and exert anti-inflammatory effects in glial cells. Preclinical studies have shown that the t...

    Authors: Harrihar A Pershadsingh, Michael T Heneka, Rashmi Saini, Navin M Amin, Daniel J Broeske and Douglas L Feinstein

    Citation: Journal of Neuroinflammation 2004 1:3

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  8. Content type: Editorial

    Welcome to the Journal of Neuroinflammation, an open-access, peer-reviewed, online journal that focuses on innate immunological responses of the central nervous system, involving microglia, astrocytes, cytokin...

    Authors: Robert E Mrak and W Sue T Griffin

    Citation: Journal of Neuroinflammation 2004 1:1

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