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  1. Content type: Research

    Microglial neuroinflammation is thought to play a role in the pathogenesis of amyotrophic lateral sclerosis (ALS). The purpose of this study was to provide a histopathological evaluation of the microglial neur...

    Authors: Sarah E Fendrick, Qing-Shan Xue and Wolfgang J Streit

    Citation: Journal of Neuroinflammation 2007 4:9

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  2. Content type: Research

    Data indicates anti-oxidant, anti-inflammatory and pro-cognitive properties of noradrenaline and analyses of post-mortem brain of Alzheimer's disease (AD) patients reveal major neuronal loss in the noradrenerg...

    Authors: Perdita L Pugh, Martin P Vidgeon-Hart, Tracey Ashmeade, Ainsley A Culbert, Zoe Seymour, Marion J Perren, Flora Joyce, Simon T Bate, Anna Babin, David J Virley, Jill C Richardson, Neil Upton and David Sunter

    Citation: Journal of Neuroinflammation 2007 4:8

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  3. Content type: Review

    Progranulin (PGRN) is a pleiotropic protein that has gained the attention of the neuroscience community with recent discoveries of mutations in the gene for PGRN that cause frontotemporal lobar degeneration (F...

    Authors: Zeshan Ahmed, Ian RA Mackenzie, Michael L Hutton and Dennis W Dickson

    Citation: Journal of Neuroinflammation 2007 4:7

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  4. Content type: Research

    Male Lewis rats (6 weeks-old) were submitted to a calorie restriction equivalent to 33% or 66% of food restriction. Fifteen days later, groups of 7 animals were injected with complete Freund's adjuvant plus sp...

    Authors: Ana I Esquifino, Pilar Cano, Vanessa Jimenez-Ortega, María P Fernández-Mateos and Daniel P Cardinali

    Citation: Journal of Neuroinflammation 2007 4:6

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  5. Content type: Research

    infection induces an acute phase response that is accompanied by non-specific symptoms collectively named sickness behavior. Recent observations suggest that microglial cells play a role in mediating behaviora...

    Authors: Afina W Lemstra, Jacqueline CM Groen in't Woud, Jeroen JM Hoozemans, Elise S van Haastert, Annemiek JM Rozemuller, Piet Eikelenboom and Willem A van Gool

    Citation: Journal of Neuroinflammation 2007 4:4

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  6. Content type: Case study

    Autism is complex neuro-developmental disorder which has a symptomatic diagnosis in patients characterized by disorders in language/communication, behavior, and social interactions. The exact causes for autism...

    Authors: Marvin Boris, Claudia C Kaiser, Allan Goldblatt, Michael W Elice, Stephen M Edelson, James B Adams and Douglas L Feinstein

    Citation: Journal of Neuroinflammation 2007 4:3

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  7. Content type: Research

    The pathogenesis of idiopathic Parkinson's disease (PD) remains elusive, although evidence has suggested that neuroinflammation characterized by activation of resident microglia in the brain may contribute sig...

    Authors: Jinghua Jin, Feng-Shiun Shie, Jun Liu, Yan Wang, Jeanne Davis, Aimee M Schantz, Kathleen S Montine, Thomas J Montine and Jing Zhang

    Citation: Journal of Neuroinflammation 2007 4:2

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  8. Content type: Research

    Our recent results show that all-trans retinoic acid (ATRA), an active metabolite of vitamin A, induces COX-dependent hyperalgesia and allodynia in rats. This effect was mediated by retinoic acid receptors (RARs)...

    Authors: Matilde Alique, Juan F Herrero and Francisco Javier Lucio-Cazana

    Citation: Journal of Neuroinflammation 2007 4:1

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  9. Content type: Research

    There are reasons to expect an association with Alzheimer's disease (AD) within the HLA region. The HLA-B & C genes have, however, been relatively understudied. A geographically specific association with HLA-B7 &...

    Authors: Donald J Lehmann, Martin CNM Barnardo, Susan Fuggle, Isabel Quiroga, Andrew Sutherland, Donald R Warden, Lin Barnetson, Roger Horton, Stephan Beck and A David Smith

    Citation: Journal of Neuroinflammation 2006 3:33

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  10. Content type: Research

    Substances of abuse, such as opiates, have a variety of immunomodulatory properties that may influence both neuroinflammatory and neurodegenerative disease processes. The chemokine CCL2, which plays a pivotal ...

    Authors: R Bryan Rock, Shuxian Hu, Wen S Sheng and Phillip K Peterson

    Citation: Journal of Neuroinflammation 2006 3:32

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  11. Content type: Research

    Anti-inflammatory treatment affects ischemic damage and neurogenesis in rodent models of cerebral ischemia. We investigated the potential benefit of COX-2 inhibition with parecoxib in spontaneously hypertensiv...

    Authors: Jesper Kelsen, Katrine Kjær, Gang Chen, Michael Pedersen, Lisbeth Røhl, Jørgen Frøkiær, Søren Nielsen, Jens R Nyengaard and Lars Christian B Rønn

    Citation: Journal of Neuroinflammation 2006 3:31

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  12. Content type: Research

    Secretory phospholipase A2-IIA (sPLA2-IIA) is an inflammatory protein known to play a role in the pathogenesis of many inflammatory diseases. Although this enzyme has also been implicated in the pathogenesis of n...

    Authors: Guna SD Moses, Michael D Jensen, Lih-Fen Lue, Douglas G Walker, Albert Y Sun, Agnes Simonyi and Grace Y Sun

    Citation: Journal of Neuroinflammation 2006 3:28

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  13. Content type: Research

    Microglia are associated with neuritic plaques in Alzheimer disease (AD) and serve as a primary component of the innate immune response in the brain. Neuritic plaques are fibrous deposits composed of the amylo...

    Authors: Carol A Colton, Ryan T Mott, Hayley Sharpe, Qing Xu, William E Van Nostrand and Michael P Vitek

    Citation: Journal of Neuroinflammation 2006 3:27

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  14. Content type: Research

    There is increased interest in the contribution of the innate immune system to multiple sclerosis (MS), including the activity of acute inflammatory mediators. The purpose of this study was to test the involve...

    Authors: Timothy J Cunningham, Lihua Yao, Michelle Oetinger, Laura Cort, Elizabeth P Blankenhorn and Jeffrey I Greenstein

    Citation: Journal of Neuroinflammation 2006 3:26

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  15. Content type: Research

    The nonapeptide CHEC-9 (CHEASAAQC), a putative inhibitor of secreted phospholipase A2 (sPLA2), has been shown previously to inhibit neuron death and aspects of the inflammatory response following systemic trea...

    Authors: Timothy J Cunningham, Jaquie Maciejewski and Lihua Yao

    Citation: Journal of Neuroinflammation 2006 3:25

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  16. Content type: Research

    Alzheimer's disease is characterized by the accumulation of neuritic plaques, containing activated microglia and β-amyloid peptides (Aβ). Fibrillar Aβ can activate microglia, resulting in production of toxic a...

    Authors: Aiste Jekabsone, Palwinder K Mander, Anna Tickler, Martyn Sharpe and Guy C Brown

    Citation: Journal of Neuroinflammation 2006 3:24

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  17. Content type: Research

    A correlation between plasma CD31+ endothelial microparticles (CD31+EMP) levels and clinical, as well as brain MRI activity, in multiple sclerosis (MS) patients has been previously reported. However, the effec...

    Authors: William A Sheremata, Wenche Jy, Sylvia Delgado, Alireza Minagar, Jerry McLarty and Yeon Ahn

    Citation: Journal of Neuroinflammation 2006 3:23

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  18. Content type: Research

    In meningitis, the cerebrospinal fluid contains high levels of innate immune molecules (e.g. complement) which are essential to ward off the infectious challenge and to promote the infiltration of phagocytes (...

    Authors: Cecile Canova, Jim W Neal and Philippe Gasque

    Citation: Journal of Neuroinflammation 2006 3:22

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  19. Content type: Research

    Innate immune activation, including a role for cluster of differentiation 14/toll-like receptor 4 co-receptors (CD14/TLR-4) co-receptors, has been implicated in paracrine damage to neurons in several neurodege...

    Authors: Izumi Maezawa, Snjezana Zaja-Milatovic, Dejan Milatovic, Christina Stephen, Izabela Sokal, Nobuyo Maeda, Thomas J Montine and Kathleen S Montine

    Citation: Journal of Neuroinflammation 2006 3:21

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  20. Content type: Short report

    Treatment of susceptible rats with dopaminergic agonists that reduce prolactin release decreases both severity and duration of clinical signs of experimental allergic encephalomyelitis (EAE). To assess to what...

    Authors: Ana I Esquifino, Pilar Cano, Agustín Zapata and Daniel P Cardinali

    Citation: Journal of Neuroinflammation 2006 3:20

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  21. Content type: Review

    Theiler's murine encephalomyelitis virus (TMEV) is divided into two subgroups on the basis of their different biological activities. GDVII subgroup strains produce fatal poliomyelitis in mice without virus per...

    Authors: Masumi Takano-Maruyama, Yoshiro Ohara, Kunihiko Asakura and Takako Okuwa

    Citation: Journal of Neuroinflammation 2006 3:19

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  22. Content type: Research

    Cerebrovascular deposition of fibrillar amyloid β-protein (Aβ), a condition known as cerebral amyloid angiopathy (CAA), is a prominent pathological feature of Alzheimer's disease (AD) and related disorders. Ac...

    Authors: Mary Lou Previti, Weibing Zhang and William E Van Nostrand

    Citation: Journal of Neuroinflammation 2006 3:18

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  23. Content type: Research

    Microglial activation has been proposed to facilitate clearance of amyloid β protein (Aβ) from the brain following Aβ immunotherapy in amyloid precursor protein (APP) transgenic mice. Interleukin-1 receptor 1 ...

    Authors: Pritam Das, Lisa A Smithson, Robert W Price, Vallie M Holloway, Yona Levites, Paramita Chakrabarty and Todd E Golde

    Citation: Journal of Neuroinflammation 2006 3:17

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  24. Content type: Short report

    Based on their potent anti-inflammatory properties and a preliminary clinical trial, statins (HMG-CoA reductase inhibitors) are being studied as possible candidates for multiple sclerosis (MS) therapy. The pat...

    Authors: Esther Zeinstra, Nadine Wilczak, Daniel Chesik, Lisa Glazenburg, Frans GM Kroese and Jacques De Keyser

    Citation: Journal of Neuroinflammation 2006 3:16

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  25. Content type: Research

    The cytokines IL-1α and IL-1β are induced rapidly after insults to the CNS, and their subsequent signaling through the type 1 IL-1 receptor (IL-1R1) has been regarded as essential for a normal astroglial and m...

    Authors: Hsiao-Wen Lin, Anirban Basu, Charles Druckman, Michael Cicchese, J Kyle Krady and Steven W Levison

    Citation: Journal of Neuroinflammation 2006 3:15

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  26. Content type: Research

    Immunotherapy for Alzheimer's disease (AD) is emerging as a potential treatment. However, a clinical trial (AN1792) was halted after adverse effects occurred in a small subset of subjects, which may have been ...

    Authors: Timothy J Seabrook, Liying Jiang, Katelyn Thomas and Cynthia A Lemere

    Citation: Journal of Neuroinflammation 2006 3:14

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  27. Content type: Research

    Multiple sclerosis (MS) is a central nervous system-specific autoimmune, demyelinating and neurodegenerative disease. Infiltration of lesions by autoaggressive, myelin-specific CD4+Th1 cells correlates with cl...

    Authors: Dusanka S Skundric, Juan Cai, William W Cruikshank and Djordje Gveric

    Citation: Journal of Neuroinflammation 2006 3:13

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  28. Content type: Research

    Stroke is one of the leading causes of death worldwide and a major cause of morbidity and mortality in the United States of America. Brain ischemia-reperfusion (IR) triggers a complex series of biochemical eve...

    Authors: Manu Jatana, Shailendra Giri, Mubeen A Ansari, Chinnasamy Elango, Avtar K Singh, Inderjit Singh and Mushfiquddin Khan

    Citation: Journal of Neuroinflammation 2006 3:12

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  29. Content type: Research

    Antibodies against the Aß peptide clear Aß deposits when injected intracranially. Deglycosylated antibodies have reduced effector functions compared to their intact counterparts, potentially avoiding immune ac...

    Authors: Niki C Carty, Donna M Wilcock, Arnon Rosenthal, Jan Grimm, Jaume Pons, Victoria Ronan, Paul E Gottschall, Marcia N Gordon and Dave Morgan

    Citation: Journal of Neuroinflammation 2006 3:11

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  30. Content type: Research

    Inheritance of the three different alleles of the human apolipoprotein (apo) E gene (APOE) are associated with varying risk or clinical outcome from a variety of neurologic diseases. ApoE isoform-specific modulat...

    Authors: Izumi Maezawa, Nobuyo Maeda, Thomas J Montine and Kathleen S Montine

    Citation: Journal of Neuroinflammation 2006 3:10

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  31. Content type: Research

    C3a and C5a anaphylatoxins are proinflammatory polypeptides released during complement activation. They exert their biological activities through interaction with two G protein-coupled receptors named C3aR and...

    Authors: Anne-christine Jauneau, Alexander Ischenko, Alexandra Chatagner, Magalie Benard, Philippe Chan, Marie-therese Schouft, Christine Patte, Hubert Vaudry and Marc Fontaine

    Citation: Journal of Neuroinflammation 2006 3:8

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  32. Content type: Research

    Alzheimer's disease is a neurodegenerative disorder characterized by a progressive cognitive impairment, the consequence of neuronal dysfunction and ultimately the death of neurons. The amyloid hypothesis prop...

    Authors: Clive Bate, Sarah Kempster, Victoria Last and Alun Williams

    Citation: Journal of Neuroinflammation 2006 3:7

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  33. Content type: Research

    Accumulating evidence suggests that inflammation plays an important role in the progression of Parkinson's disease (PD). Among many inflammatory factors found in the PD brain, cyclooxygenase (COX), specificall...

    Authors: Rattanavijit Vijitruth, Mei Liu, Dong-Young Choi, Xuan V Nguyen, Randy L Hunter and Guoying Bing

    Citation: Journal of Neuroinflammation 2006 3:6

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  34. Content type: Research

    Clinical and neuropathological overlap between Alzheimer's (AD) and Parkinson's disease (PD) is now well recognized. Such cases of concurrent AD and Lewy body disease (AD/LBD) show neuropathological changes th...

    Authors: W Sue T Griffin, Ling Liu, Yuekui Li, Robert E Mrak and Steven W Barger

    Citation: Journal of Neuroinflammation 2006 3:5

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  35. Content type: Research

    Oxidative stress is believed to be an early event and a key factor in Alzheimer's disease (AD) pathogenesis and progression. In spite of an intensive search for surrogate markers to monitor changes related to ...

    Authors: Luisa Minghetti, Anita Greco, Maria Puopolo, Marc Combrinck, Donald Warden and A David Smith

    Citation: Journal of Neuroinflammation 2006 3:4

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  36. Content type: Research

    We have previously shown that transgenic mice carrying a mutant human APP but deficient in CD40L, display a decrease in astrocytosis and microgliosis associated with a lower amount of deposited Aβ. Furthermore...

    Authors: Vincent Laporte, Ghania Ait-Ghezala, Claude-Henry Volmar and Michael Mullan

    Citation: Journal of Neuroinflammation 2006 3:3

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  37. Content type: Research

    Detailed study of glial inflammation has been hindered by lack of cell culture systems that spontaneously demonstrate the "neuroinflammatory phenotype". Mice expressing a glycine → alanine substitution in cyto...

    Authors: Kenneth Hensley, Haitham Abdel-Moaty, Jerrod Hunter, Molina Mhatre, Shenyun Mou, Kim Nguyen, Tamara Potapova, Quentin N Pye, Min Qi, Heather Rice, Charles Stewart, Katharine Stroukoff and Melinda West

    Citation: Journal of Neuroinflammation 2006 3:2

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  38. Content type: Research

    Evidence exists suggesting that the immune system may contribute to the severity of idiopathic Parkinson's disease (IPD). The data presented here demonstrates that antibodies in the sera of patients with IPD h...

    Authors: Victor C Huber, Tapan Mondal, Stewart A Factor, Richard F Seegal and David A Lawrence

    Citation: Journal of Neuroinflammation 2006 3:1

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  39. Content type: Research

    Activated microglial cells have been implicated in a number of neurodegenerative disorders, including Alzheimer's disease (AD), multiple sclerosis (MS), and HIV dementia. It is well known that inflammatory med...

    Authors: Jared Ehrhart, Demian Obregon, Takashi Mori, Huayan Hou, Nan Sun, Yun Bai, Thomas Klein, Francisco Fernandez, Jun Tan and R Douglas Shytle

    Citation: Journal of Neuroinflammation 2005 2:29

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  40. Content type: Research

    Alzheimer's disease, a common dementia of the elder, is characterized by accumulation of protein amyloid deposits in the brain. Immunization to prevent this accumulation has been proposed as a therapeutic poss...

    Authors: Jun Zhou, Maria I Fonseca, Rakez Kayed, Irma Hernandez, Scott D Webster, Ozkan Yazan, David H Cribbs, Charles G Glabe and Andrea J Tenner

    Citation: Journal of Neuroinflammation 2005 2:28

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  41. Content type: Short report

    Neuronal expression of cyclooxygenase-2 (COX-2) and cell cycle proteins is suggested to contribute to neurodegeneration during Alzheimer's disease (AD). The stimulus that induces COX-2 and cell cycle protein e...

    Authors: Jeroen JM Hoozemans, Elise S van Haastert, Robert Veerhuis, Thomas Arendt, Wiep Scheper, Piet Eikelenboom and Annemieke JM Rozemuller

    Citation: Journal of Neuroinflammation 2005 2:27

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  42. Content type: Research

    The aim of the present study was to examine inflammatory responses during Wallerian degeneration in rat peripheral nerve when the regrowth of axons was prevented by suturing.

    Authors: Saku Ruohonen, Mohsen Khademi, Maja Jagodic, Hanna-Stiina Taskinen, Tomas Olsson and Matias Röyttä

    Citation: Journal of Neuroinflammation 2005 2:26

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  43. Content type: Research

    Propagated tissue degeneration, especially during aging, has been shown to be enhanced through potentiation of innate immune responses. Neurodegenerative diseases and a wide variety of inflammatory conditions ...

    Authors: Jari Huuskonen, Tiina Suuronen, Riitta Miettinen, Thomas van Groen and Antero Salminen

    Citation: Journal of Neuroinflammation 2005 2:25

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  44. Content type: Research

    Alzheimer's disease is a complex neurodegenerative disorder characterized pathologically by a temporal and spatial progression of beta-amyloid (Aβ) deposition, neurofibrillary tangle formation, and synaptic de...

    Authors: Michelle C Janelsins, Michael A Mastrangelo, Salvatore Oddo, Frank M LaFerla, Howard J Federoff and William J Bowers

    Citation: Journal of Neuroinflammation 2005 2:23

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  45. Content type: Research

    Inflammation is suspected to contribute to the progression and severity of neurodegeneration in Alzheimer's disease (AD). Transgenic mice overexpressing the london mutant of amyloid precursor protein, APP [V71...

    Authors: Michael T Heneka, Magdalena Sastre, Lucia Dumitrescu-Ozimek, Ilse Dewachter, Jochen Walter, Thomas Klockgether and Fred Van Leuven

    Citation: Journal of Neuroinflammation 2005 2:22

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