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  1. Microglia are essential to maintain cell homeostasis in the healthy brain and are activated after brain injury. Upon activation, microglia polarize towards different phenotypes. The course of microglia activat...

    Authors: Sabine Ulrike Vay, Lea Jessica Flitsch, Monika Rabenstein, Helena Monière, Igor Jakovcevski, Pavle Andjus, Dunja Bijelic, Stefan Blaschke, Helene Luise Walter, Gereon Rudolf Fink, Michael Schroeter and Maria Adele Rueger

    Citation: Journal of Neuroinflammation 2020 17:100

    Content type: Research

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  2. Bladder-related pain symptoms in patients with bladder pain syndrome/interstitial cystitis (BPS/IC) are often accompanied by depression and memory deficits. Magnesium deficiency contributes to neuroinflammatio...

    Authors: Jia-Liang Chen, Xin Zhou, Bo-Long Liu, Xu-Hong Wei, Hong-Lu Ding, Zhi-Jun Lin, Hai-Lun Zhan, Fei Yang, Wen-Biao Li, Jun-Cong Xie, Min-Zhi Su, Xian-Guo Liu and Xiang-Fu Zhou

    Citation: Journal of Neuroinflammation 2020 17:99

    Content type: Research

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  3. Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder that affects cognitive and motor abilities by primarily targeting the striatum and cerebral cortex. HD is caused by a mutation elo...

    Authors: Julie C. Savage, Marie-Kim St-Pierre, Micaël Carrier, Hassan El Hajj, Sammy Weiser Novak, Maria Gabriela Sanchez, Francesca Cicchetti and Marie-Ève Tremblay

    Citation: Journal of Neuroinflammation 2020 17:98

    Content type: Research

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  4. Bacterial meningitis (BM) causes apoptotic damage to the hippocampus and homocysteine (Hcy) accumulation to neurotoxic levels in the cerebrospinal fluid of children. The Hcy pathway controls bioavailability of...

    Authors: Karina Barbosa de Queiroz, Vanessa Cavalcante-Silva, Flávia Lombardi Lopes, Gifone Aguiar Rocha, Vânia D’Almeida and Roney Santos Coimbra

    Citation: Journal of Neuroinflammation 2020 17:96

    Content type: Research

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  5. Huntington’s disease (HD) is caused by the expression of a mutated variant of Huntingtin (mHtt), which results in the complex pathology characterized by a defective function of the nervous system and altered i...

    Authors: Marian Jesabel Pérez-Rodríguez, Alfredo Ibarra-Sánchez, Abraham Román-Figueroa, Francisca Pérez-Severiano and Claudia González-Espinosa

    Citation: Journal of Neuroinflammation 2020 17:95

    Content type: Research

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  6. Recent years have seen an explosion of research pertaining to biological psychiatry, yet despite subsequent advances in our understanding of neuroimmune communication pathways, how the brain senses and respond...

    Authors: Carolyn A. Thomson, Alison McColl, Gerard J. Graham and Jonathan Cavanagh

    Citation: Journal of Neuroinflammation 2020 17:94

    Content type: Research

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  7. Increased circulating levels of tumor necrosis factor (TNF) are associated with greater risk of impaired neurodevelopment after preterm birth. In this study, we tested the hypothesis that systemic TNF inhibiti...

    Authors: Robert Galinsky, Simerdeep K. Dhillon, Justin M. Dean, Joanne O. Davidson, Christopher A. Lear, Guido Wassink, Fraser Nott, Sharmony B. Kelly, Mhoyra Fraser, Caroline Yuill, Laura Bennet and Alistair Jan Gunn

    Citation: Journal of Neuroinflammation 2020 17:92

    Content type: Research

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  8. Early-life stress (ES) is an emerging risk factor for later life development of Alzheimer’s disease (AD). We have previously shown that ES modulates amyloid-beta pathology and the microglial response to it in ...

    Authors: Maralinde R. Abbink, Janssen M. Kotah, Lianne Hoeijmakers, Aline Mak, Genevieve Yvon-Durocher, Bram van der Gaag, Paul J. Lucassen and Aniko Korosi

    Citation: Journal of Neuroinflammation 2020 17:91

    Content type: Research

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  9. Inflammatory response mediated by oxidative stress is considered as an important pathogenesis of spinal cord injury (SCI). Advanced oxidation protein products (AOPPs) are novel markers of oxidative stress and ...

    Authors: Zhongyuan Liu, Xinqiang Yao, Wangsheng Jiang, Wei Li, Siyuan Zhu, Congrui Liao, Lin Zou, Ruoting Ding and Jianting Chen

    Citation: Journal of Neuroinflammation 2020 17:90

    Content type: Research

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  10. The interaction between astrocytes and microglia plays a vital role in the damage and repair of brain lesions due to traumatic brain injury (TBI). Recent studies have shown that exosomes act as potent mediator...

    Authors: Xiaobing Long, Xiaolong Yao, Qian Jiang, Yiping Yang, Xuejun He, Weidong Tian, Kai Zhao and Huaqiu Zhang

    Citation: Journal of Neuroinflammation 2020 17:89

    Content type: Research

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  11. The participation of microglia in CNS development and homeostasis indicate that these cells are pivotal for the regeneration that occurs after demyelination. The clearance of myelin debris and the inflammatory...

    Authors: Miriam Mecha, Natalia Yanguas-Casás, Ana Feliú, Leyre Mestre, Francisco Javier Carrillo-Salinas, Kristoffer Riecken, Diego Gomez-Nicola and Carmen Guaza

    Citation: Journal of Neuroinflammation 2020 17:88

    Content type: Research

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  12. An emerging problem in the treatment of breast cancer is the increasing incidence of metastases to the brain. Metastatic brain tumours are incurable and can cause epileptic seizures and cognitive impairment, s...

    Authors: Anna Simon, Ming Yang, Joanne L. Marrison, Andrew D. James, Mark J. Hunt, Peter J. O’Toole, Paul M. Kaye, Miles A. Whittington, Sangeeta Chawla and William J. Brackenbury

    Citation: Journal of Neuroinflammation 2020 17:87

    Content type: Research

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  13. Guillain-Barré syndrome (GBS) is an autoimmune disease that results in demyelination and axonal damage. Five percent of patients die and 20% remain significantly disabled on recovery. Recovery is slow in most ...

    Authors: Patrick Altmann, Desiree De Simoni, Alexandra Kaider, Birgit Ludwig, Jakob Rath, Fritz Leutmezer, Fritz Zimprich, Romana Hoeftberger, Michael P. Lunn, Amanda Heslegrave, Thomas Berger, Henrik Zetterberg and Paulus Stefan Rommer

    Citation: Journal of Neuroinflammation 2020 17:86

    Content type: Research

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  14. A growing body of studies have indicated that bone marrow mesenchymal stem cells (BMSCs) have powerful analgesic effects in animal models of bone cancer pain. Here, we explored the molecular mechanisms underly...

    Authors: Chao Zhu, Kun Wang, Zhi Chen, Yingchao Han, Hao Chen, Quan Li, Zude Liu, Lie Qian, Jun Tang and Hongxing Shen

    Citation: Journal of Neuroinflammation 2020 17:85

    Content type: Research

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  15. Studies suggest a role of the innate immune system, including the activity of neutrophils, in neurodegeneration related to Alzheimer’s disease (AD), but prospective cognitive data remain lacking in humans. We ...

    Authors: Kritleen K. Bawa, Saffire H. Krance, Nathan Herrmann, Hugo Cogo-Moreira, Michael Ouk, Di Yu, Che-Yuan Wu, Sandra E. Black, Krista L. Lanctôt and Walter Swardfager

    Citation: Journal of Neuroinflammation 2020 17:84

    Content type: Research

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  16. Spinal cord microglia plays a crucial role in the pathogenesis of neuropathic pain. However, the mechanisms underlying spinal microglial activation during neuropathic pain remain incompletely determined. Here,...

    Authors: Lijuan Wang, Cui Yin, Tianya Liu, Mannan Abdul, Yan Zhou, Jun-Li Cao and Chen Lu

    Citation: Journal of Neuroinflammation 2020 17:83

    Content type: Research

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  17. Sema4A is a regulator of helper T cell (Th) activation and differentiation in the priming phase, which plays an important role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE) and multipl...

    Authors: Toru Koda, Akiko Namba, Makoto Kinoshita, Yuji Nakatsuji, Tomoyuki Sugimoto, Kaori Sakakibara, Satoru Tada, Mikito Shimizu, Kazuya Yamashita, Kazushiro Takata, Teruyuki Ishikura, Syo Murata, Shohei Beppu, Atsushi Kumanogoh, Hideki Mochizuki and Tatsusada Okuno

    Citation: Journal of Neuroinflammation 2020 17:82

    Content type: Research

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  18. Acute inflammation induced by reactive astrocytes after cerebral ischemia/reperfusion (I/R) injury is important for protecting the resultant lesion. Our previous study demonstrated that DJ-1 is abundantly expr...

    Authors: Li Peng, Yang Zhou, Ning Jiang, Tingting Wang, Jin Zhu, Yanlin Chen, Linyu Li, Jinyan Zhang, Shanshan Yu and Yong Zhao

    Citation: Journal of Neuroinflammation 2020 17:81

    Content type: Research

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  19. The gut microbiota regulates the host immune and nervous systems and plays an important role in the pathogenesis of autoimmune neurological disease multiple sclerosis (MS). There are considerable efforts curre...

    Authors: Clemens Gödel, Birgit Kunkel, Alireza Kashani, Hans Lassmann, Manimozhiyan Arumugam and Gurumoorthy Krishnamoorthy

    Citation: Journal of Neuroinflammation 2020 17:79

    Content type: Short report

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  20. Cerebral amyloid angiopathy (CAA) is a common cerebral small vessel disease of the aged and a prominent comorbidity of Alzheimer’s disease (AD). CAA can promote a variety of vascular-related pathologies includ...

    Authors: Xiaoyue Zhu, Joshua Hatfield, Joseph K. Sullivan, Feng Xu and William E. Van Nostrand

    Citation: Journal of Neuroinflammation 2020 17:78

    Content type: Research

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  21. Western pattern diets induce neuroinflammation and impair cognitive behavior in humans and animals. Neuroinflammation and cognitive impairment have been associated with microbiota dysbiosis, through the gut-br...

    Authors: Hongli Shi, Qiao Wang, Mingxuan Zheng, Shanshan Hao, Jeremy S. Lum, Xi Chen, Xu-Feng Huang, Yinghua Yu and Kuiyang Zheng

    Citation: Journal of Neuroinflammation 2020 17:77

    Content type: Research

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  22. Tick-borne encephalitis virus (TBEV) is a member of the Flaviviridae family, Flavivirus genus, which includes several important human pathogens. It is responsible for neurological symptoms that may cause permanen...

    Authors: Mazigh Fares, Marielle Cochet-Bernoin, Gaëlle Gonzalez, Claudia N. Montero-Menei, Odile Blanchet, Alexandra Benchoua, Claire Boissart, Sylvie Lecollinet, Jennifer Richardson, Nadia Haddad and Muriel Coulpier

    Citation: Journal of Neuroinflammation 2020 17:76

    Content type: Research

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  23. Cinobufagin is the major bufadienolide of Bufonis venenum (Chansu), which has been traditionally used for the treatment of chronic pain especially cancer pain. The current study aimed to evaluate its antinocicept...

    Authors: Evhy Apryani, Usman Ali, Zi-Ying Wang, Hai-Yun Wu, Xiao-Fang Mao, Khalil Ali Ahmad, Xin-Yan Li and Yong-Xiang Wang

    Citation: Journal of Neuroinflammation 2020 17:75

    Content type: Research

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  24. Inflammation is a potential crucial factor in the pathogenesis of subarachnoid hemorrhage (SAH). Circulating microRNAs (miRNAs) are involved in the regulation of diverse aspects of neuronal dysfunction. The th...

    Authors: Niansheng Lai, Degang Wu, Tianyu Liang, Pengjie Pan, Guiqiang Yuan, Xiang Li, Haiying Li, Haitao Shen, Zhong Wang and Gang Chen

    Citation: Journal of Neuroinflammation 2020 17:74

    Content type: Research

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  25. The recruitment of immune system cells into the central nervous system (CNS) has a profound effect on the outcomes of injury and disease. Glia-derived chemoattractants, including chemokines, play a pivotal rol...

    Authors: Lun Li, Li Ni, Robert F. Heary and Stella Elkabes

    Citation: Journal of Neuroinflammation 2020 17:73

    Content type: Research

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  26. Tau hyper-phosphorylation has been considered a major contributor to neurodegeneration in Alzheimer’s disease (AD) and related tauopathies, and has gained prominence in therapeutic development for AD. To eluci...

    Authors: Yao Sun, Yongqing Guo, Xuejian Feng, Meng Jia, Ning Ai, Yue Dong, Yayuan Zheng, Lu Fu, Bin Yu, Haihong Zhang, Jiaxin Wu, Xianghui Yu, Hui Wu and Wei Kong

    Citation: Journal of Neuroinflammation 2020 17:72

    Content type: Research

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  27. Patients with liver cirrhosis may develop hepatic encephalopathy. Rats with chronic hyperammonemia exhibit neurological alterations mediated by peripheral inflammation and neuroinflammation. Motor incoordinati...

    Authors: Tiziano Balzano, Yaiza M. Arenas, Sherry Dadsetan, Jerónimo Forteza, Sara Gil-Perotin, Laura Cubas-Nuñez, Bonaventura Casanova, Francisco Gracià, Natalia Varela-Andrés, Carmina Montoliu, Marta Llansola and Vicente Felipo

    Citation: Journal of Neuroinflammation 2020 17:70

    Content type: Research

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  28. Interferon-γ (IFN-γ, a type II IFN) is present in the central nervous system (CNS) under various conditions. Evidence is emerging that, in addition to its immunological role, IFN-γ modulates neuronal morpholog...

    Authors: Gabriel M. S. Janach, Olivia Reetz, Noah Döhne, Konstantin Stadler, Sabine Grosser, Egor Byvaltcev, Anja U. Bräuer and Ulf Strauss

    Citation: Journal of Neuroinflammation 2020 17:69

    Content type: Research

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  29. CD8+ T lymphocytes are critical mediators of neuroinflammatory diseases. Understanding the mechanisms that govern the function of this T cell population is crucial to better understanding central nervous system a...

    Authors: Mahdia Benkhoucha, Isis Senoner and Patrice H. Lalive

    Citation: Journal of Neuroinflammation 2020 17:68

    Content type: Research

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  30. ADAMTS13 (a disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13) plays a vital role in preventing microvascular thrombosis and inflammation. Reduced ADAMTS13 levels in plasma have bee...

    Authors: Kaili Lu, Lan Liu, Xiaofeng Xu, Fei Zhao, Jiangshan Deng, Xin Tang, Xiuzhe Wang, Bing-Qiao Zhao, Xiaojie Zhang and Yuwu Zhao

    Citation: Journal of Neuroinflammation 2020 17:67

    Content type: Research

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  31. Adipocyte fatty acid–binding protein (FABP4) is an adipokine that plays an important role in development of cardiovascular and metabolic diseases. The aim of this study was to assess the 3-month prognostic val...

    Authors: Yong-Gang Luo, Bing Han, Tong-Wen Sun, Xianzhi Liu, Jun Liu and Jun Zhang

    Citation: Journal of Neuroinflammation 2020 17:66

    Content type: Research

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  32. Alzheimer’s disease (AD) is a neurodegenerative disorder strongly correlated with a dysfunctional immune system. Our previous results demonstrated that inactivated influenza vaccine (IIV) facilitates hippocamp...

    Authors: Yunjie Yang, Zitian He, Zhiwei Xing, Zejie Zuo, Lifang Yuan, Yingying Wu, Mei Jiang, Fangfang Qi and Zhibin Yao

    Citation: Journal of Neuroinflammation 2020 17:65

    Content type: Research

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  33. Sepsis-associated acute brain inflammation, if unresolved, may cause chronic neuroinflammation and resultant neurodegenerative diseases. However, little is known how the transition from acute to chronic neuroi...

    Authors: Zhan Zhao, Yubao Wang, Ran Zhou, Yi Li, Yun Gao, Dezhen Tu, Belinda Wilson, Sheng Song, Jing Feng, Jau-Shyong Hong and Jerrel L. Yakel

    Citation: Journal of Neuroinflammation 2020 17:64

    Content type: Research

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  34. Neutrophil-lymphocyte ratio (NLR) and lymphocyte-monocyte ratio (LMR) are associated with clinical outcomes in malignancy, cardiovascular disease and stroke. Here we investigate their association with outcome ...

    Authors: Danielle Lux, Vafa Alakbarzade, Luke Bridge, Camilla N. Clark, Brian Clarke, Liqun Zhang, Usman Khan and Anthony C. Pereira

    Citation: Journal of Neuroinflammation 2020 17:60

    Content type: Research

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  35. A sustained inflammatory response following spinal cord injury (SCI) contributes to neuronal damage, inhibiting functional recovery. Macrophages, the major participants in the inflammatory response, transform ...

    Authors: Fan-Qi Kong, Shu-Jie Zhao, Peng Sun, Hao Liu, Jian Jie, Tao Xu, An-Di Xu, Ya-Qing Yang, Ye Zhu, Jian Chen, Zheng Zhou, Ding-Fei Qian, Chang-Jiang Gu, Qi Chen, Guo-Yong Yin, Han-Wen Zhang…

    Citation: Journal of Neuroinflammation 2020 17:62

    Content type: Research

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  36. Alzheimer’s disease (AD) is a major clinical problem, but there is a distinct lack of effective therapeutic drugs for this disease. We investigated the potential therapeutic effects of zerumbone, a subtropical...

    Authors: Lei Li, Xiang-Hui Wu, Xiao-Jing Zhao, Lu Xu, Cai-Long Pan and Zhi-Yuan Zhang

    Citation: Journal of Neuroinflammation 2020 17:61

    Content type: Research

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  37. Oxidative stress and inflammatory pathways are involved in migraine and endogenous antioxidant defense system has a role in the prevention of hyperalgesia in migraine. In this study, we aimed to evaluate the r...

    Authors: Giovanna Casili, Marika Lanza, Alessia Filippone, Michela Campolo, Irene Paterniti, Salvatore Cuzzocrea and Emanuela Esposito

    Citation: Journal of Neuroinflammation 2020 17:59

    Content type: Research

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  38. Chitinase 3-like 1 (CHI3L1), chitinase 3-like 2 (CHI3L2), and neuronal pentraxin II (NPTX2) are inflammatory biomarkers of Alzheimer’s disease (AD). Although studies have demonstrated that cerebrospinal fluid ...

    Authors: Marta Moreno-Rodriguez, Sylvia E. Perez, Muhammad Nadeem, Michael Malek-Ahmadi and Elliott J. Mufson

    Citation: Journal of Neuroinflammation 2020 17:58

    Content type: Research

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  39. Microglia activation is associated with the development of hypoxic–ischemic brain injury (HIBI). Neuroinflammation suppression might be a suitable therapeutic target in hypoxic oligodendrocyte injury. This stu...

    Authors: Di Xie, Xiaoli Ge, Yanli Ma, Jialong Tang, Yang Wang, Yajie Zhu, Chengjin Gao and Shuming Pan

    Citation: Journal of Neuroinflammation 2020 17:57

    Content type: Research

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  40. In the last decade, there has been growing evidence that an interaction exists between inflammation and the kynurenine pathway in schizophrenia. Additionally, many authors found microglial activation in cases ...

    Authors: Bruno Pedraz-Petrozzi, Osama Elyamany, Christoph Rummel and Christoph Mulert

    Citation: Journal of Neuroinflammation 2020 17:56

    Content type: Review

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  41. Accumulating data suggest a central role for brain microglia in mediating cortical neuronal death in Alzheimer’s disease (AD), and for Toll-like receptor 2 (TLR2) in their toxic activation. Amyloid deposition ...

    Authors: Neta Lax, Nina Fainstein, Yossi Nishri, Ayal Ben-Zvi and Tamir Ben-Hur

    Citation: Journal of Neuroinflammation 2020 17:55

    Content type: Research

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  42. Transcutaneous auricular vagus nerve stimulation (taVNS) is a relatively non-invasive alternative treatment for patients suffering from major depressive disorder (MDD). It has been postulated that acupuncture ...

    Authors: Chun-Hong Liu, Ming-Hao Yang, Guang-Zhong Zhang, Xiao-Xu Wang, Bin Li, Meng Li, Marie Woelfer, Martin Walter and Lihong Wang

    Citation: Journal of Neuroinflammation 2020 17:54

    Content type: Review

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  43. Atypical antipsychotic agents, such as clozapine, are used to treat schizophrenia and other psychiatric disorders by a mechanism that is believed to involve modulating the immune system. Multiple sclerosis is ...

    Authors: Katharina Robichon, Vimal Patel, Bronwen Connor and Anne Camille La Flamme

    Citation: Journal of Neuroinflammation 2020 17:53

    Content type: Research

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  44. Microglia play a key role in neuronal circuit and synaptic maturation in the developing brain. In the healthy adult, however, their role is less clear: microglial hyperactivation in adults can be detrimental t...

    Authors: Simone N. De Luca, Alita Soch, Luba Sominsky, Thai-Xinh Nguyen, Abdulhameed Bosakhar and Sarah J. Spencer

    Citation: Journal of Neuroinflammation 2020 17:52

    Content type: Research

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  45. Radiotherapy is widely used and effective for treating brain tumours, but inevitably impairs cognition as it arrests cellular processes important for learning and memory. This is particularly evident in the ag...

    Authors: Lukasz Wlodarek, Feng Cao, Faisal J. Alibhai, Adam Fekete, Nima Noyan, Stephanie W. Tobin, Tina B. Marvasti, Jun Wu, Shu-Hong Li, Richard D. Weisel, Lu-Yang Wang, Zhengping Jia and Ren-Ke Li

    Citation: Journal of Neuroinflammation 2020 17:51

    Content type: Research

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  46. Astrocytes are the most abundant glial cells in a brain that mediate inflammatory responses and provide trophic support for neurons. We have previously disclosed that paroxetine, a common selective serotonin r...

    Authors: Xiong Zhang, Lan-Bing Zhu, Jia-Hui He, Hong-Qiu Zhang, Shu-Ya Ji, Chao-Nan Zhang, Na-Na Hou, Chen-Ping Huang and Jian-Hong Zhu

    Citation: Journal of Neuroinflammation 2020 17:50

    Content type: Research

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  47. Spinal cord injury (SCI) can lead to severe motor and sensory dysfunction with high disability and mortality. In recent years, mesenchymal stem cell (MSC)-secreted nano-sized exosomes have shown great potentia...

    Authors: Wei Liu, Yuluo Rong, Jiaxing Wang, Zheng Zhou, Xuhui Ge, Chengyue Ji, Dongdong Jiang, Fangyi Gong, Linwei Li, Jian Chen, Shujie Zhao, Fanqi Kong, Changjiang Gu, Jin Fan and Weihua Cai

    Citation: Journal of Neuroinflammation 2020 17:47

    Content type: Research

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