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  1. Substance P (SP) is produced at high levels in the central nervous system (CNS), and its target receptor, neurokinin 1 receptor (NK-1R), is expressed by glia and leukocytes. This tachykinin functions to exacer...

    Authors: Alejandra N. Martinez, Amanda R. Burmeister, Geeta Ramesh, Lara Doyle-Meyers, Ian Marriott and Mario T. Philipp
    Citation: Journal of Neuroinflammation 2017 14:37
  2. Microglia and its polarization play critical roles in intracerebral hemorrhage-induced secondary brain injury. Programmed death protein 1/programmed death-ligand 1 has been reported to regulate neuroimmune cel...

    Authors: Jie Wu, Liang Sun, Haiying Li, Haitao Shen, Weiwei Zhai, Zhengquan Yu and Gang Chen
    Citation: Journal of Neuroinflammation 2017 14:36
  3. Histone deacetylase inhibitor (HDACi), sodium butyrate (SB), has been shown to be neuroprotective in adult brain injury models. Potential explanation for the inhibitor action involves among others reduced infl...

    Authors: Joanna Jaworska, Malgorzata Ziemka-Nalecz, Joanna Sypecka and Teresa Zalewska
    Citation: Journal of Neuroinflammation 2017 14:34
  4. The spatial learning abilities of developing mice benefit from extrinsic cues, such as an enriched environment, with concomitant enhancement in cognitive functions. Interestingly, such enhancements can be furt...

    Authors: Fangfang Qi, Zejie Zuo, Junhua Yang, Saisai Hu, Yang Yang, Qunfang Yuan, Juntao Zou, Kaihua Guo and Zhibin Yao
    Citation: Journal of Neuroinflammation 2017 14:32
  5. Central nervous system tuberculosis (CNS-TB) may be fatal even with treatment. Neutrophils are the key mediators of TB immunopathology, and raised CSF matrix metalloproteinase-9 (MMP-9) which correlates to neu...

    Authors: Catherine W. M. Ong, Przemyslaw J. Pabisiak, Sara Brilha, Poonam Singh, Federico Roncaroli, Paul T. Elkington and Jon S. Friedland
    Citation: Journal of Neuroinflammation 2017 14:31
  6. This study examined the development of chronic pain, a cardinal symptom of rheumatoid arthritis (RA), in mice with antigen- and collagen-induced arthritis (ACIA). Since the role of CD8+ T cells in arthritis is co...

    Authors: Uta Baddack-Werncke, Melanie Busch-Dienstfertig, Sara González-Rodríguez, Santhosh Chandar Maddila, Jenny Grobe, Martin Lipp, Christoph Stein and Gerd Müller
    Citation: Journal of Neuroinflammation 2017 14:30
  7. Pro-inflammatory cytokines accumulate in the brain with age and Alzheimer’s disease and can impair neuron health and cognitive function. Brain-derived neurotrophic factor (BDNF) is a key neurotrophin that supp...

    Authors: Anthony J. Carlos, Liqi Tong, G. Aleph Prieto and Carl W. Cotman
    Citation: Journal of Neuroinflammation 2017 14:29
  8. Lyme neuroborreliosis (LNB), caused by the spirochete Borrelia burgdorferi (Bb), affects both the central and peripheral nervous systems. Previously, we reported that in a model of acute LNB in rhesus monkeys, tr...

    Authors: Geeta Ramesh, Alejandra N. Martinez, Dale S. Martin and Mario T. Philipp
    Citation: Journal of Neuroinflammation 2017 14:28
  9. B cell immunity, including the chemokine CXCL13, has an established role in Lyme neuroborreliosis, and also, T helper (Th) 17 immunity, including IL-17A, has recently been implicated.

    Authors: Paula Gyllemark, Pia Forsberg, Jan Ernerudh and Anna J. Henningsson
    Citation: Journal of Neuroinflammation 2017 14:27
  10. The multiligand receptor megalin controls the brain uptake of a number of ligands, including insulin and leptin. Despite the role of megalin in the transport of these metabolically relevant hormones, the role ...

    Authors: Fernando Bartolome, Desiree Antequera, Eva Tavares, Consuelo Pascual, Rosario Maldonado, Antoni Camins and Eva Carro
    Citation: Journal of Neuroinflammation 2017 14:26
  11. The mammalian target of rapamycin (mTOR) is a kinase involved in a variety of physiological and pathological functions. However, the exact role of mTOR in excitotoxicity is poorly understood. Here, we investig...

    Authors: Soraya Wilke Saliba, Erica Leandro Marciano Vieira, Rebeca Priscila de Melo Santos, Eduardo Candelario-Jalil, Bernd L. Fiebich, Luciene Bruno Vieira, Antonio Lucio Teixeira and Antonio Carlos Pinheiro de Oliveira
    Citation: Journal of Neuroinflammation 2017 14:25
  12. Toll-like receptors (TLRs) are transmembrane pattern-recognition receptors of the innate immune system recognizing diverse pathogen-derived and tissue damage-related ligands. It has been suggested that TLR sig...

    Authors: María Calvo-Rodríguez, Carmen de la Fuente, Mónica García-Durillo, Carmen García-Rodríguez, Carlos Villalobos and Lucía Núñez
    Citation: Journal of Neuroinflammation 2017 14:24
  13. Abnormal activation of the complement system contributes to some central nervous system diseases but the role of complement in HIV-associated neurocognitive disorder (HAND) is unclear.

    Authors: Jadwiga Nitkiewicz, Alejandra Borjabad, Susan Morgello, Jacinta Murray, Wei Chao, Luni Emdad, Paul B. Fisher, Mary Jane Potash and David J. Volsky
    Citation: Journal of Neuroinflammation 2017 14:23
  14. Stroke is one of the leading causes of death worldwide. A strong inflammatory response characterized by activation and release of cytokines, chemokines, adhesion molecules, and proteolytic enzymes contributes ...

    Authors: Vibha Shukla, Akhalesh Kumar Shakya, Miguel A. Perez-Pinzon and Kunjan R. Dave
    Citation: Journal of Neuroinflammation 2017 14:21
  15. Steroid-responsive meningitis-arteritis (SRMA) is an immune-mediated disorder characterized by neutrophilic pleocytosis and an arteritis particularly in the cervical leptomeninges. Previous studies of the dise...

    Authors: Jessica Freundt-Revilla, Arianna Maiolini, Regina Carlson, Martin Beyerbach, Kai Rentmeister, Thomas Flegel, Andrea Fischer and Andrea Tipold
    Citation: Journal of Neuroinflammation 2017 14:20
  16. Endoplasmic reticulum (ER) stress is a hallmark of neurodegenerative diseases such as multiple sclerosis (MS). However, this physiological mechanism has multiple manifestations that range from impaired clearan...

    Authors: Yohannes Haile, Xiaodan Deng, Carolina Ortiz-Sandoval, Nasser Tahbaz, Aleksandra Janowicz, Jian-Qiang Lu, Bradley J. Kerr, Nicholas J. Gutowski, Janet E. Holley, Paul Eggleton, Fabrizio Giuliani and Thomas Simmen
    Citation: Journal of Neuroinflammation 2017 14:19
  17. Ischemic stroke causes a strong inflammatory response that includes T cells, monocytes/macrophages, and neutrophils. Interaction of these immune cells with platelets and endothelial cells facilitates microvasc...

    Authors: Michael K. Schuhmann, Josua Guthmann, Guido Stoll, Bernhard Nieswandt, Peter Kraft and Christoph Kleinschnitz
    Citation: Journal of Neuroinflammation 2017 14:18
  18. Considerable evidence has shown that neuroinflammation and oxidative stress play an important role in the pathophysiology of postoperative cognitive dysfunction (POCD) and other progressive neurodegenerative d...

    Authors: Wei-Xing Zhao, Jun-Han Zhang, Jiang-Bei Cao, Wei Wang, Dong-Xin Wang, Xiao-Ying Zhang, Jun Yu, Yong-Yi Zhang, You-Zhi Zhang and Wei-Dong Mi
    Citation: Journal of Neuroinflammation 2017 14:17
  19. Fatigue is commonly reported in a variety of illnesses, and it has major impact on quality of life. Previously, it was thought that fatigue originates in the skeletal muscles, leading to cessation of activity....

    Authors: Megan E. Roerink, Marieke E. van der Schaaf, Charles A. Dinarello, Hans Knoop and Jos W. M. van der Meer
    Citation: Journal of Neuroinflammation 2017 14:16
  20. Microglia is responsible for neuroinflammation, which may aggravate brain injury in diseases like epilepsy. Mammalian target of rapamycin (mTOR) kinase is related to microglial activation with subsequent neuro...

    Authors: Ming-Tao Yang, Yi-Chin Lin, Whae-Hong Ho, Chao-Lin Liu and Wang-Tso Lee
    Citation: Journal of Neuroinflammation 2017 14:15
  21. The bromodomain and extraterminal domain (BET) family proteins (BET2, BET3, and BET4) “read” (bind) histone acetylation marks via two distinct bromodomains (Brom1 and Brom2) facilitating transcriptional activa...

    Authors: Lei Zhao, Jun Li, Yingmei Fu, Mengxue Zhang, Bowen Wang, Jonathan Ouellette, Pawan K. Shahi, Bikash R. Pattnaik, Jyoti J. Watters, Wai T. Wong and Lian-Wang Guo
    Citation: Journal of Neuroinflammation 2017 14:14
  22. Accumulating evidence indicate that B cells can exhibit pro- or anti-inflammatory activities. Similar to interleukin (IL)-10–competent B cells, we recently showed that transforming growth factor (TGF)-β1-produ...

    Authors: Nicolas Molnarfi, Kristbjörg Bjarnadóttir, Mahdia Benkhoucha, Catherine Juillard and Patrice H. Lalive
    Citation: Journal of Neuroinflammation 2017 14:13
  23. Inflammatory processes play a pivotal role in the degenerative process of Alzheimer’s disease. In humans, a biallelic (C/T) polymorphism in the promoter region (position-511) (rs16944) of the interleukin-1 bet...

    Authors: Chi-Wei Huang, Shih-Wei Hsu, Shih-Jen Tsai, Nai-Ching Chen, Mu-En Liu, Chen-Chang Lee, Shu-Hua Huang, Weng-Neng Chang, Ya-Ting Chang, Wan-Chen Tsai and Chiung-Chih Chang
    Citation: Journal of Neuroinflammation 2017 14:12
  24. B lymphocytes are thought to play a relevant role in multiple sclerosis (MS) pathology. The in vivo analysis of intrathecally produced B cell-related cytokines may help to clarify the mechanisms of B cell recr...

    Authors: M. Puthenparampil, L. Federle, S. Miante, A. Zito, E. Toffanin, S. Ruggero, M. Ermani, S. Pravato, D. Poggiali, P. Perini, F. Rinaldi and P. Gallo
    Citation: Journal of Neuroinflammation 2017 14:11
  25. Epilepsy is a common and debilitating consequence of traumatic brain injury (TBI). Seizures contribute to progressive neurodegeneration and poor functional and psychosocial outcomes for TBI survivors, and epil...

    Authors: Kyria M. Webster, Mujun Sun, Peter Crack, Terence J. O’Brien, Sandy R. Shultz and Bridgette D. Semple
    Citation: Journal of Neuroinflammation 2017 14:10
  26. Multiple sclerosis (MS) is an autoimmune demyelinating disease that affects the central nervous system (CNS), leading to neurodegeneration and chronic disability. Accumulating evidence points to a key role for...

    Authors: Ellen Merckx, Giulia Albertini, Magdalena Paterka, Cathy Jensen, Philipp Albrecht, Michael Dietrich, Joeri Van Liefferinge, Eduard Bentea, Lise Verbruggen, Thomas Demuyser, Lauren Deneyer, Jan Lewerenz, Geert van Loo, Jacques De Keyser, Hideyo Sato, Pamela Maher…
    Citation: Journal of Neuroinflammation 2017 14:9
  27. Neuroinflammatory processes including activated microglia have been reported to play an important role in Parkinson’s disease (PD). Increased expression of translocator protein (TSPO) has been observed after b...

    Authors: Christine Ghadery, Yuko Koshimori, Sarah Coakeley, Madeleine Harris, Pablo Rusjan, Jinhee Kim, Sylvain Houle and Antonio P. Strafella
    Citation: Journal of Neuroinflammation 2017 14:8
  28. α/β-Hydrolase domain 6 (ABHD6) is one of the major enzymes for endocannabinoid 2-arachidonoylglycerol (2-AG) hydrolysis in microglia cells. Our recent studies have shown that a selective ABHD6 inhibitor WWL70 ...

    Authors: Mikiei Tanaka, Sean Moran, Jie Wen, Kwame Affram, Tinghua Chen, Aviva J. Symes and Yumin Zhang
    Citation: Journal of Neuroinflammation 2017 14:7
  29. Mounting evidence indicates that children who experience abuse and neglect are prone to chronic diseases and premature mortality later in life. One mechanistic hypothesis for this phenomenon is that early life...

    Authors: Yangzi Zhu, Yu Wang, Rui Yao, Ting Hao, Junli Cao, He Huang, Liwei Wang and Yuqing Wu
    Citation: Journal of Neuroinflammation 2017 14:6
  30. Diet-induced hypothalamic inflammation is an important mechanism leading to dysfunction of neurons involved in controlling body mass. Studies have shown that polyunsaturated fats can reduce hypothalamic inflam...

    Authors: Livia B. Pascoal, Bruna Bombassaro, Albina F. Ramalho, Andressa Coope, Rodrigo F. Moura, Felipe Correa-da-Silva, Leticia Ignacio-Souza, Daniela Razolli, Diogo de Oliveira, Rodrigo Catharino and Licio A. Velloso
    Citation: Journal of Neuroinflammation 2017 14:5
  31. Age-related macular degeneration (AMD) is the leading cause of blindness in developed countries. The polymorphism rs10490924 in the ARMS2 gene is highly associated with AMD and linked to an indel mutation (del443...

    Authors: Sven Micklisch, Yuchen Lin, Saskia Jacob, Marcus Karlstetter, Katharina Dannhausen, Prasad Dasari, Monika von der Heide, Hans-Martin Dahse, Lisa Schmölz, Felix Grassmann, Medhanie Alene, Sascha Fauser, Harald Neumann, Stefan Lorkowski, Diana Pauly, Bernhard H. Weber…
    Citation: Journal of Neuroinflammation 2017 14:4
  32. Cyclooxygenase-2 (COX-2) is induced under inflammatory conditions, and prostaglandin E2 (PGE2) is one of the products of COX activity. PGE2 has pleiotropic actions depending on the activation of specific E-type p...

    Authors: Ester Bonfill-Teixidor, Amaia Otxoa-de-Amezaga, Miriam Font-Nieves, M. Glòria Sans-Fons and Anna M. Planas
    Citation: Journal of Neuroinflammation 2017 14:3
  33. Pneumococcal meningitis is the most common and severe form of bacterial meningitis. Fatality rates are substantial, and long-term sequelae develop in about half of survivors. Disease outcome has been related t...

    Authors: E. Soemirien Kasanmoentalib, Mercedes Valls Seron, Bart Ferwerda, Michael W. Tanck, Aeilko H. Zwinderman, Frank Baas, Arie van der Ende, Matthijs C. Brouwer and Diederik van de Beek
    Citation: Journal of Neuroinflammation 2017 14:2

    The Erratum to this article has been published in Journal of Neuroinflammation 2017 14:77

  34. Treatment of mild-moderate Alzheimer’s disease (AD) subjects (N = 119) for 52 weeks with the SIRT1 activator resveratrol (up to 1 g by mouth twice daily) attenuates progressive declines in CSF Aβ40 levels and act...

    Authors: Charbel Moussa, Michaeline Hebron, Xu Huang, Jaeil Ahn, Robert A. Rissman, Paul S. Aisen and R. Scott Turner
    Citation: Journal of Neuroinflammation 2017 14:1
  35. Infectious encephalitides are most often associated with acute seizures during the infection period and are risk factors for the development of epilepsy at later times. Mechanisms of viral encephalitis-induced...

    Authors: Nina Dupuis, Andrey Mazarati, Béatrice Desnous, Vibol Chhor, Bobbi Fleiss, Tifenn Le Charpentier, Sophie Lebon, Zsolt Csaba, Pierre Gressens, Pascal Dournaud and Stéphane Auvin
    Citation: Journal of Neuroinflammation 2016 13:307
  36. Understanding blood-brain barrier responses to inflammatory stimulation (such as lipopolysaccharide mimicking a systemic infection or a cytokine cocktail that could be the result of local or systemic inflammat...

    Authors: Jacquelyn A. Brown, Simona G. Codreanu, Mingjian Shi, Stacy D. Sherrod, Dmitry A. Markov, M. Diana Neely, Clayton M. Britt, Orlando S. Hoilett, Ronald S. Reiserer, Philip C. Samson, Lisa J. McCawley, Donna J. Webb, Aaron B. Bowman, John A. McLean and John P. Wikswo
    Citation: Journal of Neuroinflammation 2016 13:306
  37. Hyperglycemia is a significant risk factor for diabetic retinopathy and induces increased inflammatory responses and retinal leukostasis, as well as vascular damage. Although there is an increasing amount of e...

    Authors: Eun-Ah Ye, Li Liu, Youde Jiang, Jenny Jan, Subhash Gaddipati, Susmit Suvas and Jena J. Steinle
    Citation: Journal of Neuroinflammation 2016 13:305
  38. Neuroinflammation is characterized by microglial activation and the increased levels of cytokines and chemokines in the central nervous system (CNS). Recent evidence has implicated both beneficial and toxic ro...

    Authors: Longyu Yang, Chia-Chen Liu, Honghua Zheng, Takahisa Kanekiyo, Yuka Atagi, Lin Jia, Daxin Wang, Aurelie N’songo, Dan Can, Huaxi Xu, Xiao-Fen Chen and Guojun Bu
    Citation: Journal of Neuroinflammation 2016 13:304
  39. Tollip is a ubiquitously expressed protein, originally described as a modulator of the IL-1R/TLR-NF-κB signaling pathways. Although this property has been well characterized in peripheral cells, and despite so...

    Authors: Marie Humbert-Claude, D. Duc, D. Dwir, L. Thieren, J. Sandström von Tobel, C. Begka, F. Legueux, D. Velin, M. H. Maillard, K. Q. Do, F. Monnet-Tschudi and L. Tenenbaum
    Citation: Journal of Neuroinflammation 2016 13:303
  40. Multiple sclerosis (MS) is a chronic CNS autoimmune disease characterized by inflammation, demyelination, and neuronal degeneration, where myelin-specific CD4 T cells play critical roles in the formation of ac...

    Authors: Patrick K Nuro-Gyina, Elizabeth L Rieser, Marissa C Granitto, Wei Pei, Yue Liu, Priscilla W Lee, Saba Aqel, Jian Zhang, Amy E Lovett-Racke, Michael K Racke and Yuhong Yang
    Citation: Journal of Neuroinflammation 2016 13:302
  41. Studies of neuromyelitis optica (NMO), an autoimmune disease of the central nervous system (CNS), have demonstrated that autoantibodies against the water channel aquaporin-4 (AQP4) induce astrocyte damage thro...

    Authors: Yiting Liu, Danielle E. Harlow, Katherine S. Given, Gregory P. Owens, Wendy B. Macklin and Jeffrey L. Bennett
    Citation: Journal of Neuroinflammation 2016 13:301
  42. Sodium butyrate (NaB) is a histone deacetylase (HDAC) inhibitor exhibiting anti-inflammatory and neuroprotective effects in a rat ischemic model of stroke as well as a myocardial ischemia model. Although clini...

    Authors: Min Jung Park and Farida Sohrabji
    Citation: Journal of Neuroinflammation 2016 13:300
  43. Traumatic brain injury (TBI) patients in military settings can be exposed to prolonged periods of hypobaria (HB) during aeromedical evacuation. Hypobaric exposure, even with supplemental oxygen to prevent hypo...

    Authors: Jacob W. Skovira, Junfang Wu, Jessica J. Matyas, Alok Kumar, Marie Hanscom, Shruti V. Kabadi, Raymond Fang and Alan I. Faden
    Citation: Journal of Neuroinflammation 2016 13:299
  44. Progressive myoclonus epilepsy of Unverricht-Lundborg type (EPM1) is an autosomal recessively inherited childhood-onset neurodegenerative disorder, characterized by myoclonus, seizures, and ataxia. Mutations i...

    Authors: Olesya Okuneva, Zhilin Li, Inken Körber, Saara Tegelberg, Tarja Joensuu, Li Tian and Anna-Elina Lehesjoki
    Citation: Journal of Neuroinflammation 2016 13:298
  45. The inflammatory response is critical to fight insults, such as pathogen invasion or tissue damage, but if not resolved often becomes detrimental to the host. A growing body of evidence places non-resolved inf...

    Authors: Diogo Lobo-Silva, Guilhermina M. Carriche, A. Gil Castro, Susana Roque and Margarida Saraiva
    Citation: Journal of Neuroinflammation 2016 13:297
  46. Prostaglandin E2 (PGE2)-involved neuroinflammatory processes are prevalent in several neurological conditions and diseases. Amyloid burden is correlated with the activation of E-prostanoid (EP) 2 receptors by PGE

    Authors: Gen-Lin He, Zhen Luo, Ting-Ting Shen, Ping Li, Ju Yang, Xue Luo, Chun-Hai Chen, Peng Gao and Xue-Sen Yang
    Citation: Journal of Neuroinflammation 2016 13:296
  47. Mutations in leucine-rich repeat kinase 2 (LRRK2) contribute to both familial and idiopathic forms of Parkinson’s disease (PD). Neuroinflammation is a key event in neurodegeneration and aging, and there is mou...

    Authors: Rakel López de Maturana, Valérie Lang, Amaia Zubiarrain, Amaya Sousa, Nerea Vázquez, Ana Gorostidi, Julio Águila, Adolfo López de Munain, Manuel Rodríguez and Rosario Sánchez-Pernaute
    Citation: Journal of Neuroinflammation 2016 13:295

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