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  1. Glial cell activation and overproduction of inflammatory mediators in the central nervous system (CNS) have been implicated in acute traumatic injuries to the CNS, including spinal cord injury (SCI). Elevated ...

    Authors: Hans G Novrup, Valerie Bracchi-Ricard, Ditte G Ellman, Jerome Ricard, Anjana Jain, Erik Runko, Lise Lyck, Minna Yli-Karjanmaa, David E Szymkowski, Damien D Pearse, Kate L Lambertsen and John R Bethea
    Citation: Journal of Neuroinflammation 2014 11:159
  2. Preterm brain injury consists primarily of periventricular leukomalacia accompanied by elements of gray-matter injury, and these injuries are associated with cerebral palsy and cognitive impairments. Inflammat...

    Authors: Anna-Maj Albertsson, Dan Bi, Luqi Duan, Xiaoli Zhang, Jianmei W Leavenworth, Lili Qiao, Changlian Zhu, Susanna Cardell, Harvey Cantor, Henrik Hagberg, Carina Mallard and Xiaoyang Wang
    Citation: Journal of Neuroinflammation 2014 11:153
  3. Abnormal tau hyperphosphorylation and its accumulation into intra-neuronal neurofibrillary tangles are linked to neurodegeneration in Alzheimer’s disease and similar tauopathies. One strategy to reduce accumul...

    Authors: Maj-Linda B Selenica, Hayk Davtyan, Steven B Housley, Laura J Blair, Anne Gillies, Bryce A Nordhues, Bo Zhang, Joseph Liu, Jason E Gestwicki, Daniel C Lee, Marcia N Gordon, Dave Morgan and Chad A Dickey
    Citation: Journal of Neuroinflammation 2014 11:152
  4. Progression of neurodegenerative diseases occurs when microglia, upon persistent activation, perpetuate a cycle of damage in the central nervous system. Use of mesenchymal stem cells (MSC) has been suggested a...

    Authors: Shinsmon Jose, Shi Wei Tan, Yin Yin Ooi, Rajesh Ramasamy and Sharmili Vidyadaran
    Citation: Journal of Neuroinflammation 2014 11:149
  5. During cerebral inflammation uracil nucleotides leak to the extracellular medium and activate glial pyrimidine receptors contributing to the development of a reactive phenotype. Chronically activated microglia...

    Authors: Clara Quintas, Diana Pinho, Clara Pereira, Lucília Saraiva, Jorge Gonçalves and Glória Queiroz
    Citation: Journal of Neuroinflammation 2014 11:141
  6. Spinal cord injuries remain a critical issue in experimental and clinical research nowadays, and it is now well accepted that the immune response and subsequent inflammatory reactions are of significant import...

    Authors: Virginie Neirinckx, Cécile Coste, Rachelle Franzen, André Gothot, Bernard Rogister and Sabine Wislet
    Citation: Journal of Neuroinflammation 2014 11:150
  7. The fatty acid amide palmitoylethanolamide (PEA) has been studied extensively for its anti-inflammatory and neuroprotective actions. The lipidic nature and large particle size of PEA in the native state may li...

    Authors: Daniela Impellizzeri, Giuseppe Bruschetta, Marika Cordaro, Rosalia Crupi, Rosalba Siracusa, Emanuela Esposito and Salvatore Cuzzocrea
    Citation: Journal of Neuroinflammation 2014 11:136

    The Erratum to this article has been published in Journal of Neuroinflammation 2016 13:129

  8. Aberrant neuroinflammation is suspected to contribute to the pathogenesis of myriad neurological diseases. As such, determining the pathways that promote or inhibit glial activation is of interest. Activation ...

    Authors: Andrew J Steelman and Jianrong Li
    Citation: Journal of Neuroinflammation 2014 11:144
  9. In recent years, studies have sought to understand the mechanisms involved in the alteration of autophagic flux in Alzheimer's disease (AD). Alongside the recent description of the impairment of lysosomal acid...

    Authors: Arnaud François, Agnès Rioux Bilan, Nathalie Quellard, Bèatrice Fernandez, Thierry Janet, Damien Chassaing, Marc Paccalin, Faraj Terro and Guylène Page
    Citation: Journal of Neuroinflammation 2014 11:139
  10. We reported previously that amoeboid microglial cells in the postnatal rat brain expressed 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNPase) both in vivo and in vitro; however, the functional role of CNPase i...

    Authors: Lijuan Yang, Enci Mary Kan, Jia Lu, Chunyun Wu and Eng-Ang Ling
    Citation: Journal of Neuroinflammation 2014 11:148
  11. Infection of rabies virus (RABV) causes central nervous system (CNS) dysfunction and results in high mortality in human and animals. However, it is still unclear whether and how CNS inflammation and immune res...

    Authors: Ying Huang, Shaozhuo Jiao, Xiaoyan Tao, Qing Tang, Wentao Jiao, Jun Xiao, Xiaoyan Xu, Yanbo Zhang, Guodong Liang and Hongyan Wang
    Citation: Journal of Neuroinflammation 2014 11:146
  12. Inhibition of TNFα protects the retina against diabetic-like changes in rodent models. The mechanism by which TNFα induces deleterious retinal changes is not known. Previously, we have shown that TNFα can inhi...

    Authors: Youde Jiang, Qiuhua Zhang, Eun-Ah Ye and Jena J Steinle
    Citation: Journal of Neuroinflammation 2014 11:137
  13. Neuroinflammation mediated by overactivated microglia plays a key role in many neurodegenerative diseases, including Alzheimer’s disease (AD). In this study, we investigated for the first time the anti-neuroin...

    Authors: Zhen-Yi Hong, Xue-Ru Shi, Kai Zhu, Ting-Ting Wu and Yi-Zhun Zhu
    Citation: Journal of Neuroinflammation 2014 11:147
  14. IL-6 is a proinflammatory cytokine reported to play an important role in the induction of cerebral vasospasm after subarachnoid hemorrhage (SAH). Suppressor of cytokine signaling 3 (SOCS3) is known to act as a...

    Authors: Koji Osuka, Yasuo Watanabe, Masahiro Aoyama, Takahiro Nakura, Naoki Matsuo and Masakazu Takayasu
    Citation: Journal of Neuroinflammation 2014 11:142
  15. Lithium, an effective mood stabilizer for the treatment of bipolar disorders, has been recently suggested to have a role in neuroprotection during neurodegenerative diseases. The pathogenesis of neurological d...

    Authors: Hongquan Dong, Xiang Zhang, Xiaonan Dai, Shunmei Lu, Bo Gui, Wenjie Jin, Susu Zhang, Shu Zhang and Yanning Qian
    Citation: Journal of Neuroinflammation 2014 11:140
  16. Immune system cells are known to affect loss of neurons due to injury or disease. Recruitment of immune cells following retinal/CNS injury has been shown to affect the health and survival of neurons in several...

    Authors: Neal D Heuss, Mark J Pierson, Kim Ramil C Montaniel, Scott W McPherson, Ute Lehmann, Stacy A Hussong, Deborah A Ferrington, Walter C Low and Dale S Gregerson
    Citation: Journal of Neuroinflammation 2014 11:143
  17. Microglia are the primary immunocompetent cells in brain tissue and microglia-mediated inflammation is associated with the pathogenesis of various neuronal disorders. Recently, many studies have shown that mes...

    Authors: Yi Liu, Run Zhang, Ke Yan, Fanfan Chen, Weiyi Huang, Bingke Lv, Chengmei Sun, Limin Xu, Feng Li and Xiaodan Jiang
    Citation: Journal of Neuroinflammation 2014 11:135
  18. Infants born preterm commonly suffer from a combination of hypoxia-ischemia (HI) and infectious perinatal inflammatory insults that lead to cerebral palsy, cognitive delay, behavioral issues and epilepsy. Usin...

    Authors: Lauren L Jantzie, Christopher J Corbett, Jacqueline Berglass, Daniel J Firl, Julian Flores, Rebekah Mannix and Shenandoah Robinson
    Citation: Journal of Neuroinflammation 2014 11:131
  19. We report a novel method of culturing microglia in three dimension (3D) using collagen as a substrate. By culturing microglia within a matrix, we aim to emulate the physical state of microglia embedded within ...

    Authors: Randy Tatt Yhew Haw, Chih Kong Tong, Andrew Yew, Han Chung Lee, James B Phillips and Sharmili Vidyadaran
    Citation: Journal of Neuroinflammation 2014 11:134
  20. Neuromyelitis optica (NMO, Devic syndrome) is associated with antibodies to aquaporin-4 (NMO-IgG/AQP4-Ab) in the majority of cases. NMO-IgG/AQP4-Ab seropositivity in patients with NMO and its spectrum disorder...

    Authors: Sven Jarius, Friedemann Paul, Kai Fechner, Klemens Ruprecht, Ingo Kleiter, Diego Franciotta, Marius Ringelstein, Florence Pache, Orhan Aktas and Brigitte Wildemann
    Citation: Journal of Neuroinflammation 2014 11:129
  21. An accumulating body of evidence points to the significance of neuroinflammation and immunogenetics in schizophrenia, and an imbalance of cytokines in the central nervous system (CNS) has been suggested to be ...

    Authors: Itziar Gil-Pisa, Carolina Cebrián, Jorge E Ortega, J Javier Meana and David Sulzer
    Citation: Journal of Neuroinflammation 2014 11:128
  22. Genetic and environmental factors are critical elements influencing the etiology of major depression. It is now accepted that neuroinflammatory processes play a major role in neuropsychological disorders. Neur...

    Authors: Julie Cazareth, Alice Guyon, Catherine Heurteaux, Joëlle Chabry and Agnès Petit-Paitel
    Citation: Journal of Neuroinflammation 2014 11:132
  23. Experimental autoimmune encephalomyelitis (EAE) is an animal model of autoimmune inflammatory demyelination that is mediated by Th1 and Th17 cells. The transcription factor interferon regulatory factor 3 (IRF3...

    Authors: Denise C Fitzgerald, Kate O’Brien, Andrew Young, Zoe Fonseca-Kelly, Abdolmohamad Rostami and Bruno Gran
    Citation: Journal of Neuroinflammation 2014 11:130
  24. Glaucomatous optic neuropathy, a leading cause of blindness, can progress despite control of intraocular pressure - currently the main risk factor and target for treatment. Glaucoma progression shares mechanis...

    Authors: Blanca Rojas, Beatriz I Gallego, Ana I Ramírez, Juan J Salazar, Rosa de Hoz, Francisco J Valiente-Soriano, Marcelino Avilés-Trigueros, Maria P Villegas-Perez, Manuel Vidal-Sanz, Alberto Triviño and José M Ramírez
    Citation: Journal of Neuroinflammation 2014 11:133
  25. The polarization to different neuroinflammatory phenotypes has been described in early Alzheimer’s disease, yet the impact of these phenotypes on amyloid-beta (Aβ) pathology remains unknown. Short-term studies...

    Authors: Erica M Weekman, Tiffany L Sudduth, Erin L Abner, Gabriel J Popa, Michael D Mendenhall, Holly M Brothers, Kaitlyn Braun, Abigail Greenstein and Donna M Wilcock
    Citation: Journal of Neuroinflammation 2014 11:127
  26. Aging is characterized by a low-grade systemic inflammation that contributes to the pathogenesis of neurodegenerative disorders such as Alzheimer’s disease (AD). However, little knowledge is currently availabl...

    Authors: María J Alvarez-López, Patricia Molina-Martínez, Marco Castro-Freire, Marta Cosín-Tomás, Rosa Cristòfol, Marcelina Párrizas, Rosa María Escorihuela, Merce Pallàs, Coral Sanfeliu and Perla Kaliman
    Citation: Journal of Neuroinflammation 2014 11:126
  27. Increased activation of mammalian target of rapamycin (mTOR) is observed in numerous human cancers. Recent studies on the glioma kinome have identified several deregulated pathways that converge and activate m...

    Authors: Lucia Lisi, Emilia Laudati, Pierluigi Navarra and Cinzia Dello Russo
    Citation: Journal of Neuroinflammation 2014 11:125
  28. The paracaspase mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is crucial for lymphocyte activation through signaling to the transcription factor NF-κB. Besides functioning as a sca...

    Authors: Conor Mc Guire, Lynn Elton, Peter Wieghofer, Jens Staal, Sofie Voet, Annelies Demeyer, Daniel Nagel, Daniel Krappmann, Marco Prinz, Rudi Beyaert and Geert van Loo
    Citation: Journal of Neuroinflammation 2014 11:124
  29. Crosstalk between the immune system in the brain and the periphery may contribute to the long-term outcome both in experimental and clinical stroke. Although, the immune defense collectin surfactant protein-D ...

    Authors: Kate L Lambertsen, Kamilla Østergaard, Bettina H Clausen, Søren Hansen, Jan Stenvang, Stine B Thorsen, Michael Meldgaard, Bjarne W Kristensen, Pernille B Hansen, Grith L Sorensen and Bente Finsen
    Citation: Journal of Neuroinflammation 2014 11:123
  30. A20 (TNFAIP3) is a pleiotropic NFκB-dependent gene that terminates NFκB activation in response to inflammatory stimuli. The potent anti-inflammatory properties of A20 are well characterized in several organs. How...

    Authors: Renata Padilha Guedes, Eva Csizmadia, Herwig P Moll, Averil Ma, Christiane Ferran and Cleide Gonçalves da Silva
    Citation: Journal of Neuroinflammation 2014 11:122
  31. Acute liver failure leads to systemic complications with one of the most dangerous being a decline in neurological function, termed hepatic encephalopathy. Neurological dysfunction is exacerbated by an increas...

    Authors: Matthew McMillin, Gabriel Frampton, Michelle Thompson, Cheryl Galindo, Holly Standeford, Eric Whittington, Gianfranco Alpini and Sharon DeMorrow
    Citation: Journal of Neuroinflammation 2014 11:121
  32. Alzheimer’s disease (AD) has been reconceptualized as a dynamic pathophysiological process, where the accumulation of amyloid-beta (Aβ) is thought to trigger a cascade of neurodegenerative events resulting in ...

    Authors: Eduardo Rigon Zimmer, Antoine Leuzy, Andréa Lessa Benedet, John Breitner, Serge Gauthier and Pedro Rosa-Neto
    Citation: Journal of Neuroinflammation 2014 11:120
  33. Patients with coronary artery disease (CAD) are at risk of accelerated cognitive decline, particularly those with major depression. Mechanisms for cognitive deficits associated with CAD, and the effects of dep...

    Authors: Graham Mazereeuw, Nathan Herrmann, Hongbin Xu, Daniel Figeys, Paul I Oh, Steffany AL Bennett and Krista L Lanctôt
    Citation: Journal of Neuroinflammation 2014 11:119
  34. ent-Sauchinone is a polyphenolic compound found in plants belonging to the lignan family. ent-Sauchinone has been shown to modulate the expression of inflammatory factors through the nuclear factor-kappa B (NF-κ...

    Authors: Suk-Young Song, Yu Yeon Jung, Chul Ju Hwang, Hee Peom Lee, Chang Hyun Sok, Joo Hwan Kim, Sang Min Lee, Hyun Ok Seo, Byung Kook Hyun, Dong Young Choi, Sang Bae Han, Young Wan Ham, Bang Yeon Hwang and Jin Tae Hong
    Citation: Journal of Neuroinflammation 2014 11:118
  35. The consumption of foods rich in carotenoids that possess significant antioxidant and inflammatory modulating properties has been linked to reduced risk of neuropathology. The objective of this study was to ev...

    Authors: Jade Guest, Ross Grant, Manohar Garg, Trevor A Mori, Kevin D Croft and Ayse Bilgin
    Citation: Journal of Neuroinflammation 2014 11:117
  36. Proinflammatory cytokine interleukin-1beta (IL-1β) is expressed at high levels in the developing brain and declines to low constitutive levels in the adult. However, the pathophysiological function of IL-1β du...

    Authors: Lei Ma, Xiao-wei Li, Shi-jun Zhang, Feng Yang, Ge-min Zhu, Xiao-bing Yuan and Wen Jiang
    Citation: Journal of Neuroinflammation 2014 11:114
  37. Biologic markers of infection and inflammation have been associated with Autism Spectrum Disorders (ASD) but prior studies have largely relied on specimens taken after clinical diagnosis. Research on potential...

    Authors: Ousseny Zerbo, Cathleen Yoshida, Judith K Grether, Judy Van de Water, Paul Ashwood, Gerald N Delorenze, Robin L Hansen, Marty Kharrazi and Lisa A Croen
    Citation: Journal of Neuroinflammation 2014 11:113
  38. Inflammation plays a key role in the pathophysiology of ischemic stroke. Some proinflammatory mediators, such as cytokines and chemokines, are produced in stroke. Chemokine-like factor 1 (CKLF1), as a novel C-...

    Authors: Ling Lei Kong, Zhi Yuan Wang, Ning Han, Xiao Mei Zhuang, Zhen Zhen Wang, Hua Li and Nai Hong Chen
    Citation: Journal of Neuroinflammation 2014 11:112
  39. Having the apolipoprotein E4 (APOE-ϵ4) allele is the strongest genetic risk factor for the development of Alzheimer’s disease (AD). Accumulation of amyloid beta (Aβ) in the brain is influenced by APOE genotype. T...

    Authors: Gustavo A Rodriguez, Leon M Tai, Mary Jo LaDu and G William Rebeck
    Citation: Journal of Neuroinflammation 2014 11:111
  40. Fragile X syndrome (FXS) is the leading cause of inheritable intellectual disability in male children, and is predominantly caused by a single gene mutation resulting in expanded trinucleotide CGG-repeats with...

    Authors: Milo Careaga, Tamanna Noyon, Kirin Basuta, Judy Van de Water, Flora Tassone, Randi J Hagerman and Paul Ashwood
    Citation: Journal of Neuroinflammation 2014 11:110
  41. The functional state of glial cells, like astrocytes and microglia, critically modulates the course of neuroinflammatory and neurodegenerative diseases and can have both detrimental and beneficial effects. Gli...

    Authors: Marius Krauthausen, Simon Saxe, Julian Zimmermann, Michael Emrich, Michael T Heneka and Marcus Müller
    Citation: Journal of Neuroinflammation 2014 11:109
  42. Palmitoylethanolamide (PEA), an endogenous lipid and a congener of anandamide, possesses a wide range of effects related to metabolic and cellular homeostasis including anti-inflammatory and neuroprotective pr...

    Authors: Sandra Redlich, Sandra Ribes, Sandra Schütze and Roland Nau
    Citation: Journal of Neuroinflammation 2014 11:108
  43. Neuroinflammation mediated by activation of microglia and interruption of the blood-brain barrier (BBB) is an important factor that contributes to neuron death and infarct area diffusion in ischemia reperfusio...

    Authors: Tengyuan Liu, Tingting Zhang, Hemei Yu, Hailian Shen and Weiliang Xia
    Citation: Journal of Neuroinflammation 2014 11:107
  44. Translocation of high-mobility group box 1 (HMGB1) from nucleus could trigger inflammation. Extracellular HMGB1 up-regulates inflammatory response in sepsis as a late mediator. However, little was known about ...

    Authors: Qing Sun, Wei Wu, Yang-Chun Hu, Hua Li, Dingding Zhang, Song Li, Wei Li, Wei-De Li, Biao Ma, Jian-Hong Zhu, Meng-Liang Zhou and Chun-Hua Hang
    Citation: Journal of Neuroinflammation 2014 11:106
  45. Multiple sclerosis (MS) is characterized by central nervous system (CNS) inflammation, demyelination, and axonal degeneration. CXCL10 (IP-10), a chemokine for CXCR3+ T cells, is known to regulate T cell different...

    Authors: Emily Mills Ko, Joyce H Ma, Fuzheng Guo, Laird Miers, Eunyoung Lee, Peter Bannerman, Travis Burns, David Ko, Jiho Sohn, Athena M Soulika and David Pleasure
    Citation: Journal of Neuroinflammation 2014 11:105

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