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  1. Content type: Research

    Even in the antiretroviral treatment (ART) era, HIV-1-infected patients suffer from milder forms of HIV-1-associated neurocognitive disorders (HAND). While the viral proteins Tat and gp120 have been shown to i...

    Authors: Raj Putatunda, Yonggang Zhang, Fang Li, Xiao-Feng Yang, Mary F Barbe and Wenhui Hu

    Citation: Journal of Neuroinflammation 2018 15:287

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  2. Content type: Research

    Neuroinflammation is associated with neurodegenerative diseases, including Alzheimer’s disease (AD). Thus, modulating the neuroinflammatory response represents a potential therapeutic strategy for treating neu...

    Authors: Ju-Young Lee, Jin Han Nam, Youngpyo Nam, Hye Yeon Nam, Gwangho Yoon, Eunhwa Ko, Sang-Bum Kim, Mahealani R Bautista, Christina C Capule, Takaoki Koyanagi, Geoffray Leriche, Hwan Geun Choi, Jerry Yang, Jeongyeon Kim and Hyang-Sook Hoe

    Citation: Journal of Neuroinflammation 2018 15:286

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  3. Content type: Research

    The collective cognitive and motor deficits known as HIV-associated neurocognitive disorders (HAND) remain high even among HIV+ individuals whose antiretroviral therapy is optimized. HAND is worsened in the co...

    Authors: Sarah Kim, Yun Kyung Hahn, Elizabeth M Podhaizer, Virginia D McLane, Shiping Zou, Kurt F Hauser and Pamela E Knapp

    Citation: Journal of Neuroinflammation 2018 15:285

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  4. Content type: Research

    The pathogenic roles of receptor-mediated sphingosine 1-phosphate (S1P) signaling in cerebral ischemia have been evidenced mainly through the efficacy of FTY720 that binds non-selectively to four of the five S...

    Authors: Bhakta Prasad Gaire, Mi-Ryoung Song and Ji Woong Choi

    Citation: Journal of Neuroinflammation 2018 15:284

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  5. Content type: Research

    Cognitive dysfunction is a frequent complication to open-heart surgery. Cerebral inflammation caused by blood-brain barrier (BBB) dysfunction due to a systemic inflammatory response is considered a possible et...

    Authors: Mattias Danielson, Björn Reinsfelt, Anne Westerlind, Henrik Zetterberg, Kaj Blennow and Sven-Erik Ricksten

    Citation: Journal of Neuroinflammation 2018 15:283

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  6. Content type: Research

    Neuroinflammation has an essential impact on the pathogenesis and progression of Alzheimer’s disease (AD). Mostly mediated by microglia and astrocytes, inflammatory processes lead to degeneration of neuronal c...

    Authors: Taraneh Ebrahimi, Marcus Rust, Sarah Nele Kaiser, Alexander Slowik, Cordian Beyer, Andreas Rembert Koczulla, Jörg B. Schulz, Pardes Habib and Jan Philipp Bach

    Citation: Journal of Neuroinflammation 2018 15:282

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  7. Content type: Research

    To identify the vulnerable areas associated with systemic oxidative stress and further disruption of these vulnerable areas by measuring the associated morphology and functional network alterations in Parkinso...

    Authors: Pi-Ling Chiang, Hsiu-Ling Chen, Cheng-Hsien Lu, Yueh-Sheng Chen, Kun-Hsien Chou, Tun-Wei Hsu, Meng-Hsiang Chen, Nai-Wen Tsai, Shau-Hsuan Li and Wei-Che Lin

    Citation: Journal of Neuroinflammation 2018 15:281

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  8. Content type: Research

    Neuropathic pain is caused by damage to the nervous system, resulting in aberrant pain, which is associated with gene expression changes in the sensory pathway. However, the molecular mechanisms are not fully ...

    Authors: Hui Du, Juan Shi, Ming Wang, Shuhong An, Xingjing Guo and Zhaojin Wang

    Citation: Journal of Neuroinflammation 2018 15:280

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  9. Content type: Research

    While brain asymmetry has been a fascinating issue in neuroscience, the critical mechanism remains to be elucidated. Based on some index cases with asymmetric 18F-fluoro-2-deoxy-d-glucose positron emission tomogr...

    Authors: Yoonhyuk Jang, Soon-Tae Lee, Ji-Yeon Bae, Tae-Joon Kim, Jin-Sun Jun, Jangsup Moon, Keun-Hwa Jung, Kyung-Il Park, Sarosh R. Irani, Kon Chu and Sang Kun Lee

    Citation: Journal of Neuroinflammation 2018 15:279

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  10. Content type: Research

    Fractalkine (CX3CL1) and its receptor (CX3CR1) play an important role in regulating microglial function. We have previously shown that Cx3cr1 deficiency exacerbated tau pathology and led to cognitive impairment. ...

    Authors: Shane M. Bemiller, Nicole M. Maphis, Shane V. Formica, Gina N. Wilson, Crystal M. Miller, Guixiang Xu, Olga N. Kokiko-Cochran, Ki-Wook Kim, Steffen Jung, Judy L. Cannon, Samuel D. Crish, Astrid E. Cardona, Bruce T. Lamb and Kiran Bhaskar

    Citation: Journal of Neuroinflammation 2018 15:278

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  11. Content type: Research

    Repetitive mild traumatic brain injuries (rmTBI) are associated with cognitive deficits, inflammation, and stress-related events. We tested the effect of nutrient intake on the impact of rmTBI in an animal mod...

    Authors: Jin Yu, Hong Zhu, Saeid Taheri, William Mondy, Stephen Perry and Mark S. Kindy

    Citation: Journal of Neuroinflammation 2018 15:277

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  12. Content type: Review

    Alzheimer’s disease (AD) is a neurodegenerative disorder, most cases of which lack a clear causative event. This has made the disease difficult to characterize and, thus, diagnose. Although some cases are gene...

    Authors: Estella A. Newcombe, Judith Camats-Perna, Mallone L. Silva, Nicholas Valmas, Tee Jong Huat and Rodrigo Medeiros

    Citation: Journal of Neuroinflammation 2018 15:276

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  13. Content type: Research

    Many viruses depend on the extensive membranous network of the endoplasmic reticulum (ER) for their translation, replication, and packaging. Certain membrane modifications of the ER can be a trigger for ER str...

    Authors: Zhongyuan Tan, Wanpo Zhang, Jianhong Sun, Zuquan Fu, Xianliang Ke, Caishang Zheng, Yuan Zhang, Penghui Li, Yan Liu, Qinxue Hu, Hanzhong Wang and Zhenhua Zheng

    Citation: Journal of Neuroinflammation 2018 15:275

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  14. Content type: Research

    Undoubtedly, neuroinflammation is a major contributor to Alzheimer’s disease (AD) progression. Neuroinflammation is characterized by the activity of brain resident glial cells, in particular microglia, but als...

    Authors: M. S. Unger, P. Schernthaner, J. Marschallinger, H. Mrowetz and L. Aigner

    Citation: Journal of Neuroinflammation 2018 15:274

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  15. Content type: Research

    Complex mechanisms participate in microglial activation after a traumatic brain injury (TBI). TBI can induce autophagy and apoptosis in neurons and glial cells, and moderate hypothermia plays a protective role...

    Authors: Fengchen Zhang, Haiping Dong, Tao Lv, Ke Jin, Yichao Jin, Xiaohua Zhang and Jiyao Jiang

    Citation: Journal of Neuroinflammation 2018 15:273

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  16. Content type: Research

    Prostaglandins are products of the cyclooxygenase pathway, which is implicated in Parkinson’s disease (PD). Limited knowledge is available on mechanisms by which prostaglandins contribute to PD neurodegenerati...

    Authors: Chuhyon Corwin, Anastasia Nikolopoulou, Allen L. Pan, Mariela Nunez-Santos, Shankar Vallabhajosula, Peter Serrano, John Babich and Maria E. Figueiredo-Pereira

    Citation: Journal of Neuroinflammation 2018 15:272

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  17. Content type: Research

    The FDA-approved small-molecule drug ibrutinib is an effective targeted therapy for patients with chronic lymphocytic leukemia (CLL). Ibrutinib inhibits Bruton’s tyrosine kinase (BTK), a kinase involved in B c...

    Authors: Hye Yeon Nam, Jin Han Nam, Gwangho Yoon, Ju-Young Lee, Youngpyo Nam, Hye-Jin Kang, Hyun-Ji Cho, Jeongyeon Kim and Hyang-Sook Hoe

    Citation: Journal of Neuroinflammation 2018 15:271

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  18. Content type: Research

    Axonal degeneration and neuronal loss have been described as the major causes of irreversible clinical disability in multiple sclerosis (MS). The aryl-hydrocarbon receptor nuclear translocator 2 (ARNT2) protei...

    Authors: Tissa Rahim, Pierre Becquart, Maria-Elizabeth Baeva and Jacqueline Quandt

    Citation: Journal of Neuroinflammation 2018 15:270

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  19. Content type: Research

    Misfolding of microtubule-associated protein tau (MAPT) within neurons into neurofibrillary tangles is an important pathological feature of Alzheimer’s disease (AD). Tau pathology correlates with cognitive dec...

    Authors: Sarah C. Hopp, Yang Lin, Derek Oakley, Allyson D. Roe, Sarah L. DeVos, David Hanlon and Bradley T. Hyman

    Citation: Journal of Neuroinflammation 2018 15:269

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  20. Content type: Research

    Netrin-1 functions largely via combined receptors and downstream effectors. Evidence has shown that astrocytes express netrin-1 receptors, including DCC and UNC5H2. However, whether netrin-1 influences the fun...

    Authors: Xiaosong He, Yanqun Liu, Xiaohong Lin, Falei Yuan, Dahong Long, Zhijun Zhang, Yongting Wang, Aiguo Xuan and Guo-Yuan Yang

    Citation: Journal of Neuroinflammation 2018 15:268

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  21. Content type: Letter to the Editor

    This is a response to readers’ comments on our paper entitled “Critical role of NLRP3-caspase-1 pathway in age-dependent isoflurane-induced microglial inflammatory response and cognitive impairment” published ...

    Authors: Zhiyi Zuo, Zhi Wang, Shiyu Meng and Shuling Peng

    Citation: Journal of Neuroinflammation 2018 15:267

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  22. Content type: Letter to the Editor

    Wang Z et al. recently published a paper, titled “Critical role of NLRP3-caspase-1 pathway in age-dependent isoflurane-induced microglial inflammatory response and cognitive impairment”. The finding in this pa...

    Authors: Lei Yin, Fangping Bao, Jing Wu and Kuanyu Li

    Citation: Journal of Neuroinflammation 2018 15:266

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    The original article was published in Journal of Neuroinflammation 2018 15:109

    The Letter to the Editor to this article has been published in Journal of Neuroinflammation 2018 15:267

  23. Content type: Research

    It remains unclear whether disease course in multiple sclerosis (MS) is influenced by genetic polymorphisms. Here, we aimed to identify genetic variants associated with benign and aggressive disease courses in...

    Authors: Elia Gil-Varea, Elena Urcelay, Carles Vilariño-Güell, Carme Costa, Luciana Midaglia, Fuencisla Matesanz, Alfredo Rodríguez-Antigüedad, Jorge Oksenberg, Laura Espino-Paisan, A. Dessa Sadovnick, Albert Saiz, Luisa M. Villar, Juan Antonio García-Merino, Lluís Ramió-Torrentà, Juan Carlos Triviño, Ester Quintana…

    Citation: Journal of Neuroinflammation 2018 15:265

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  24. Content type: Research

    Animal models of sciatic nerve injury are commonly used to study neuropathic pain as well as axon regeneration. Inflammation/immune response at the site of nerve lesion is known to be an essential trigger of t...

    Authors: Enrico Gugliandolo, Ramona D’amico, Marika Cordaro, Roberta Fusco, Rosalba Siracusa, Rosalia Crupi, Daniela Impellizzeri, Salvatore Cuzzocrea and Rosanna Di Paola

    Citation: Journal of Neuroinflammation 2018 15:264

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  25. Content type: Research

    Lead (Pb), a heavy metal, and quinolinic acid (QA), a metabolite of the kynurenine pathway of tryptophan metabolism, are known neurotoxicants. Both Pb and QA impair spatial learning and memory. Pb activates as...

    Authors: Abdur Rahman, Muddanna S. Rao and Khalid M. Khan

    Citation: Journal of Neuroinflammation 2018 15:263

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  26. Content type: Research

    Infant nerve injury causes delayed adolescent neuropathic pain, but whether it also leads to psychiatric illness is unknown. Environmental enrichment (EE) increases social communication and activity. Thus, our...

    Authors: Xingrui Gong, Yongmei Chen, Jing Chang, Yue Huang, Meihau Cai and Mazhong Zhang

    Citation: Journal of Neuroinflammation 2018 15:262

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  27. Content type: Research

    Most neurodegenerative diseases associated with protein aggregation are hallmarked by activation of astrocytes. However, how astrocytes are activated or which signaling pathways in astrocytes contribute to pat...

    Authors: Y. X. Li, O. C. M. Sibon and P. F. Dijkers

    Citation: Journal of Neuroinflammation 2018 15:261

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  28. Content type: Research

    Inflammation has been proposed to contribute to the decline in adult hippocampal neurogenesis. Proinflammatory cytokines activate transcription of chemokine growth-regulated oncogene α (Gro1) in human and muri...

    Authors: Svetlana Zonis, Joshua J. Breunig, Adam Mamelak, Kolja Wawrowsky, Catherine Bresee, Nadiya Ginzburg and Vera Chesnokova

    Citation: Journal of Neuroinflammation 2018 15:260

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  29. Content type: Review

    Microglia, unique myeloid cells residing in the brain parenchyma, represent the first line of immune defense within the central nervous system. In addition to their immune functions, microglial cells play an i...

    Authors: Cinzia Dello Russo, Natalia Cappoli, Isabella Coletta, Daniele Mezzogori, Fabiola Paciello, Giacomo Pozzoli, Pierluigi Navarra and Alessandra Battaglia

    Citation: Journal of Neuroinflammation 2018 15:259

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  30. Content type: Research

    α-Synuclein (α-Syn)-induced neuroinflammation plays a crucial role in the pathogenesis of Parkinson’s disease (PD). Dopamine D2 receptor (Drd2) has been regarded as a potential anti-inflammatory target in the ...

    Authors: Ren-Hong Du, Yan Zhou, Mei-Ling Xia, Ming Lu, Jian-Hua Ding and Gang Hu

    Citation: Journal of Neuroinflammation 2018 15:258

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  31. Content type: Research

    Alzheimer’s disease (AD) is a chronic neurodegenerative disease with pathological hallmarks including the formation of extracellular aggregates of amyloid-beta (Aβ) known as plaques and intracellular tau tangl...

    Authors: Sarah M. Rothman, Keith Q. Tanis, Pallavi Gandhi, Vladislav Malkov, Jacob Marcus, Michelle Pearson, Richard Stevens, Jason Gilliland, Christopher Ware, Veeravan Mahadomrongkul, Elaine O’Loughlin, Gonzalo Zeballos, Roger Smith, Bonnie J. Howell, Joel Klappenbach, Matthew Kennedy…

    Citation: Journal of Neuroinflammation 2018 15:256

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  32. Content type: Research

    We compared the magnetic resonance imaging (MRI) features between Japanese and Caucasian patients with multiple sclerosis (MS), and identified the relationships between MRI features and disability.

    Authors: Yuri Nakamura, Laura Gaetano, Takuya Matsushita, Altermatt Anna, Till Sprenger, Ernst-Wilhelm Radue, Jens Wuerfel, Lorena Bauer, Michael Amann, Koji Shinoda, Noriko Isobe, Ryo Yamasaki, Takahiko Saida, Ludwig Kappos and Jun-ichi Kira

    Citation: Journal of Neuroinflammation 2018 15:255

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  33. Content type: Research

    Astrocytes act as immune effector cells with the ability to produce a wide array of chemokines and cytokines in response to various stimuli. Macrophage migration inhibitory factor (MIF) is inducibly expressed ...

    Authors: Yue Zhou, Wei Guo, Zhenjie Zhu, Yuming Hu, Yingjie Wang, Xuejie Zhang, Wenjuan Wang, Nan Du, Tiancheng Song, Kaini Yang, Zongyu Guan, Yongjun Wang and Aisong Guo

    Citation: Journal of Neuroinflammation 2018 15:253

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  34. Content type: Research

    Depression is one of the most common mental disorders characterized mainly by low mood and loss of interest or pleasure. About a third of patients with depression do not respond to classic antidepressant treat...

    Authors: Hong Gong, Wen-Jun Su, Zhi-Yong Cao, Yong-Jie Lian, Wei Peng, Yun-Zi Liu, Yi Zhang, Lin-Lin Liu, Ran Wu, Bo Wang, Ting Zhang, Yun-Xia Wang and Chun-Lei Jiang

    Citation: Journal of Neuroinflammation 2018 15:252

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  35. Content type: Research

    Studies show that Toll-like receptors (TLRs), members of the innate immune system, might participate in the pathogenesis of the major depressive disorder (MDD). However, evidence of this participation in the b...

    Authors: David Martín-Hernández, Javier R. Caso, J. Javier Meana, Luis F. Callado, José L. M. Madrigal, Borja García-Bueno and Juan C. Leza

    Citation: Journal of Neuroinflammation 2018 15:251

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  36. Content type: Research

    Ischaemia reperfusion (IR) induces multiple pathophysiological changes. In addition to its classical role in regulating tumourigenesis, the feedback loop formed by p53 and its driven target p53-upregulated mod...

    Authors: Xiao-Qian Li, Qian Yu, Feng-Shou Chen, Wen-Fei Tan, Zai-Li Zhang and Hong Ma

    Citation: Journal of Neuroinflammation 2018 15:250

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  37. Content type: Research

    The deficiency in 1α, 25-dihydroxyvitamin D3 (VD3) seems to increase the risk for neurodegenerative pathologies, including Parkinson’s disease (PD). The majority of its actions are mediated by the transcriptio...

    Authors: Ludmila A R Lima, Maria Janice P Lopes, Roberta O Costa, Francisco Arnaldo V Lima, Kelly Rose T Neves, Iana B F Calou, Geanne M Andrade and Glauce S B Viana

    Citation: Journal of Neuroinflammation 2018 15:249

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  38. Content type: Research

    Mast cells (MCs), the ‘first responders’ in brain injury, are able to disrupt the blood–brain barrier (BBB), but the underlying mechanism is not well understood. Tryptase is the most abundant MC secretory prod...

    Authors: Qin Zhou, Yi-wei Wang, Peng-fei Ni, Yi-nan Chen, Hong-quan Dong and Yan-ning Qian

    Citation: Journal of Neuroinflammation 2018 15:248

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  39. Content type: Research

    Microglia are multifunctional cells that are primarily neuroprotective and a deficit in their functional integrity is likely to be a contributory factor in the deteriorating neuronal function that occurs with ...

    Authors: Ana Rubio-Araiz, Orla M. Finucane, Samuel Keogh and Marina A. Lynch

    Citation: Journal of Neuroinflammation 2018 15:247

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  40. Content type: Research

    Chronic persistent airway inflammation has been associated with the comorbidity of asthma and bipolar disorder (BD). However, the direct relevance between airway inflammation and BD-like psychiatric comorbidit...

    Authors: Li Han, Leyuan Wang, Sha Tang, Lin Yuan, Shuangyan Wu, Xizi Du, Yang Xiang, Xiangping Qu, Huijun Liu, Huaiqing Luo, Xiaoqun Qin and Chi Liu

    Citation: Journal of Neuroinflammation 2018 15:246

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  41. Content type: Research

    The mechanism underlying migraine chronification remains unclear. Central sensitization may account for this progression. The microglia P2X4 receptor (P2X4R) plays a pivotal role in the central sensitization o...

    Authors: Ting Long, Wei He, Qi Pan, Shanshan Zhang, Yixin Zhang, Chaoyang Liu, Qing Liu, Guangcheng Qin, Lixue Chen and Jiying Zhou

    Citation: Journal of Neuroinflammation 2018 15:245

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  42. Content type: Research

    Parkinson’s disease (PD) is characterized by intracellular alpha-synuclein (α-syn) inclusions, progressive death of dopaminergic neurons in the substantia nigra pars compacta (SNpc), and activation of the inna...

    Authors: Gregory P. Williams, Aubrey M. Schonhoff, Asta Jurkuvenaite, Aaron D. Thome, David G. Standaert and Ashley S. Harms

    Citation: Journal of Neuroinflammation 2018 15:244

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  43. Content type: Research

    In Parkinson’s disease (PD), loss of striatal dopaminergic (DA) terminals and degeneration of DA neurons in the substantia nigra (SN) are associated with inflammation. Nucleotide-binding oligomerization domain...

    Authors: Li Cheng, Lin Chen, Xinbing Wei, Yimeng Wang, Zhiping Ren, Shenglan Zeng, Xiumei Zhang, Haitao Wen, Chengjiang Gao and Huiqing Liu

    Citation: Journal of Neuroinflammation 2018 15:243

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  44. Content type: Research

    Nod-like receptor protein 3 (NLRP3) inflammasome is a crucial factor in mediating inflammatory responses after cerebral ischemia/reperfusion (I/R), but the cellular location of NLRP3 inflammasome in cerebral I...

    Authors: Zhe Gong, Jingrui Pan, Qingyu Shen, Mei Li and Ying Peng

    Citation: Journal of Neuroinflammation 2018 15:242

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  45. Content type: Research

    Most of the animal models commonly used for preclinical research into Alzheimer’s disease (AD) largely fail to address the pathophysiology, including the impact of known risk factors, of the widely diagnosed s...

    Authors: Nina Weishaupt, Qingfan Liu, Sheojung Shin, Ramandeep Singh, Yuksel Agca, Cansu Agca, Vladimir Hachinski and Shawn Narain Whitehead

    Citation: Journal of Neuroinflammation 2018 15:241

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  46. Content type: Short report

    Autism spectrum disorder (ASD) has been associated with brain inflammation as indicated by the activation of microglia, but the triggers are not known. Extracellular vesicles (EVs) are secreted from many cells...

    Authors: Irene Tsilioni and Theoharis C. Theoharides

    Citation: Journal of Neuroinflammation 2018 15:239

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  47. Content type: Research

    Overstimulation of glutamate receptors, especially neuronal N-methyl-d-aspartate receptor (NMDAR), mediates excitatory neurotoxicity in multiple neurodegenerative diseases. However, the role of NMDAR in the regul...

    Authors: Zheng Chen, Xugang Wang, Usama Ashraf, Bohan Zheng, Jing Ye, Dengyuan Zhou, Hao Zhang, Yunfeng Song, Huanchun Chen, Shuhong Zhao and Shengbo Cao

    Citation: Journal of Neuroinflammation 2018 15:238

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