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  1. Alcohol use disorders result from repeated binge and chronic alcohol consumption followed by negative effects, such as anxiety, upon cessation. This process is associated with the activation of NLRP3 inflammas...

    Authors: Ziyi Li, Olivia Ewi Vidjro, Gengni Guo, Yanfeng Du, Yao Zhou, Qian Xie, Jiaxin Li, Keqiang Gao, Li Zhou and Tengfei Ma
    Citation: Journal of Neuroinflammation 2022 19:308
  2. Multiple sclerosis (MS) is a chronic and often disabling autoimmune disease of the central nervous system (CNS). Cerebrospinal fluid (CSF) surrounds and protects the CNS. Analysis of CSF can aid the diagnosis ...

    Authors: Frederike Straeten, Jing Zhu, Anna-Lena Börsch, Baohong Zhang, Kejie Li, I-Na Lu, Catharina Gross, Michael Heming, Xiaolin Li, Rebekah Rubin, Zhengyu Ouyang, Heinz Wiendl, Michael Mingueneau and Gerd Meyer zu Hörste
    Citation: Journal of Neuroinflammation 2022 19:306
  3. Saturated very long-chain fatty acids (VLCFA, ≥ C22), enriched in brain myelin and innate immune cells, accumulate in X-linked adrenoleukodystrophy (X-ALD) due to inherited dysfunction of the peroxisomal VLCFA...

    Authors: Bettina Zierfuss, Agnieszka Buda, Andrea Villoria-González, Maxime Logist, Jure Fabjan, Patricia Parzer, Claire Battin, Streggi Vandersteene, Inge M. E. Dijkstra, Petra Waidhofer-Söllner, Katharina Grabmeier-Pfistershammer, Peter Steinberger, Stephan Kemp, Sonja Forss-Petter, Johannes Berger and Isabelle Weinhofer
    Citation: Journal of Neuroinflammation 2022 19:305
  4. Listeria monocytogenes (Lm) is a bacterial pathogen of major concern for humans and ruminants due to its neuroinvasive potential and its ability to cause deadly encephalitis (neurolisteriosis). On one hand, polym...

    Authors: Stefano Bagatella, Neda Haghayegh Jahromi, Camille Monney, Margherita Polidori, Flavio Max Gall, Emma Marchionatti, Fabienne Serra, Rainer Riedl, Britta Engelhardt and Anna Oevermann
    Citation: Journal of Neuroinflammation 2022 19:304
  5. Considerable evidence indicates that a signaling crosstalk between the brain and periphery plays important roles in neurological disorders, and that both acute and chronic peripheral inflammation can produce b...

    Authors: Patrick R. Suman, Lisiane S. Souza, Grasielle C. Kincheski, Helen M. Melo, Mariana N. Machado, Giovanna M. C. Carvalho, Fernanda G. De Felice, Walter A. Zin and Sergio T. Ferreira
    Citation: Journal of Neuroinflammation 2022 19:303
  6. The nucleotide oligomerization domain (NOD)-like receptor family pyrin domain containing 3 (NLRP3) in dorsal root ganglion (DRG) contributes to pain hypersensitivity in multiple neuropathic pain models, but th...

    Authors: Wen Chen, Xiaotong Wang, Qingyu Sun, Yurui Zhang, Jing Liu, Tingting Hu, Weihua Wu, Chao Wei, Meng Liu, Yumeng Ding, Dianxin Liu, Yingzi Chong, Peipei Wang, Hongwei Zhu, Weihua Cui, Jiannan Zhang…
    Citation: Journal of Neuroinflammation 2022 19:302
  7. Microglia-induced excessive neuroinflammation plays a crucial role in the pathophysiology of multiple neurological diseases, such as ischaemic stroke. Controlling inflammatory responses is considered a promisi...

    Authors: Qian Xia, Shuai Gao, Tangrui Han, Meng Mao, Gaofeng Zhan, Yonghong Wang and Xing Li
    Citation: Journal of Neuroinflammation 2022 19:301
  8. Microglia, the resident phagocytes of the retina, are believed to influence the development of retinopathy, but their exact contributions to vascular integrity and neuronal loss are unknown. Therefore, utilizi...

    Authors: Kaira A. Church, Derek Rodriguez, Difernando Vanegas, Irene L. Gutierrez, Sandra M. Cardona, José L. M. Madrigal, Tejbeer Kaur and Astrid E. Cardona
    Citation: Journal of Neuroinflammation 2022 19:300
  9. Both resident microglia and invading peripheral immune cells can respond to injury and degeneration in the central nervous system. However, after dead and dying neurons have been cleared and homeostasis is re-...

    Authors: Kaitryn E. Ronning, Sarah J. Karlen and Marie E. Burns
    Citation: Journal of Neuroinflammation 2022 19:299
  10. Dendritic cells (DCs) are the most potent professional antigen-presenting cells (APCs), which play a pivotal role in inducing either inflammatory or tolerogenic response based on their subtypes and environment...

    Authors: Caiyun Liu, Jie Zhu, Yan Mi and Tao Jin
    Citation: Journal of Neuroinflammation 2022 19:298
  11. Perioperative neurocognitive disorders (PND) is a common postoperative complication associated with regional or general anesthesia and surgery. Growing evidence in both patient and animal models of PND suggest...

    Authors: Chun Cheng, Hanxi Wan, Peilin Cong, Xinwei Huang, Tingmei Wu, Mengfan He, Qian Zhang, Lize Xiong and Li Tian
    Citation: Journal of Neuroinflammation 2022 19:297
  12. Inhibition of terminal complement in neuromyelitis optica spectrum disorder (NMOSD) using eculizumab helps prevent relapses, but the exact mechanism of action of the drug remains unclear. Similarly, genetic va...

    Authors: Shuhei Nishiyama, Amy E. Wright, Itay Lotan, Takahisa Mikami, Friedemann Paul, Masashi Aoki and Michael Levy
    Citation: Journal of Neuroinflammation 2022 19:296
  13. Characterizing immune cells and conditions that govern their recruitment and function in autoimmune diseases of the nervous system or in neurodegenerative processes is an area of active investigation. We sough...

    Authors: Scott W. McPherson, Neal D. Heuss, Md. Abedin, Heidi Roehrich, Mark J. Pierson and Dale S. Gregerson
    Citation: Journal of Neuroinflammation 2022 19:295
  14. Sinonasal diseases, such as rhinosinusitis, affect up to 12% of individuals each year which constitutes these diseases as some of the most common medical conditions in the world. Exposure to environmental path...

    Authors: Brandon J. LaFever and Fumiaki Imamura
    Citation: Journal of Neuroinflammation 2022 19:294
  15. HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) is an incapacitating neuroinflammatory disorder for which no disease-modifying therapy is available, but corticosteroids provide some clinica...

    Authors: Tatiane Assone, Soraya Maria Menezes, Fernanda de Toledo Gonçalves, Victor Angelo Folgosi, Gabriela da Silva Prates, Tim Dierckx, Marcos Braz, Jerusa Smid, Michel E. Haziot, Rosa M. N. Marcusso, Flávia E. Dahy, Evelien Vanderlinden, Sandra Claes, Dominique Schols, Roberta Bruhn, Edward L. Murphy…
    Citation: Journal of Neuroinflammation 2022 19:293
  16. The hippocampus is a plastic brain area that shows functional segregation along its longitudinal axis, reflected by a higher level of long-term potentiation (LTP) in the CA1 region of the dorsal hippocampus (D...

    Authors: E. De Felice, E. Gonçalves de Andrade, M. T. Golia, F. González Ibáñez, M. Khakpour, M. A. Di Castro, S. Garofalo, E. Di Pietro, C. Benatti, N. Brunello, F. Tascedda, B. Kaminska, C. Limatola, D. Ragozzino, M. E. Tremblay, S. Alboni…
    Citation: Journal of Neuroinflammation 2022 19:292
  17. The pathophysiology of traumatic brain injury (TBI) requires further characterization to fully elucidate changes in molecular pathways. Cerebrospinal fluid (CSF) provides a rich repository of brain-associated ...

    Authors: Sandy R. Shultz, Anup D. Shah, Cheng Huang, Larissa K. Dill, Ralf B. Schittenhelm, M. Cristina Morganti-Kossmann and Bridgette D. Semple
    Citation: Journal of Neuroinflammation 2022 19:291
  18. The functional neurological outcome of patients with intracerebral hemorrhage (ICH) strongly relates to the degree of secondary brain injury (ICH-SBI) evolving within days after the initial bleeding. Different...

    Authors: Kevin Akeret, Raphael M. Buzzi, Bart R. Thomson, Nina Schwendinger, Jan Klohs, Nadja Schulthess-Lutz, Livio Baselgia, Kerstin Hansen, Luca Regli, Florence Vallelian, Michael Hugelshofer and Dominik J. Schaer
    Citation: Journal of Neuroinflammation 2022 19:290
  19. Neuroinflammation is one of the most important processes in secondary injury after traumatic brain injury (TBI). Triggering receptor expressed on myeloid cells 2 (TREM2) has been proven to exert neuroprotectiv...

    Authors: Jin Yan, Yuan Zhang, Lin Wang, Zhao Li, Shuang Tang, Yingwen Wang, Nina Gu, Xiaochuan Sun and Lin Li
    Citation: Journal of Neuroinflammation 2022 19:289
  20. Adverse pathophysiological and behavioral outcomes related to mild traumatic brain injury (mTBI), posttraumatic stress disorder (PTSD), and chronic pain are common following blast exposure and contribute to de...

    Authors: Suhjung Janet Lee, Aric F. Logsdon, Mayumi Yagi, Britahny M. Baskin, Elaine. R. Peskind, Murray M. Raskind, David G. Cook and Abigail. G. Schindler
    Citation: Journal of Neuroinflammation 2022 19:288
  21. Inflammation and increases in inflammatory cytokines are common findings in psychiatric disorders such as schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD). Meta-analyses of studi...

    Authors: Heather K. Hughes, Houa Yang, Tyler A. Lesh, Cameron S. Carter and Paul Ashwood
    Citation: Journal of Neuroinflammation 2022 19:287
  22. The most significant genetic risk factor for developing late-onset Alzheimer’s disease (AD) is the ε4 allele of apolipoprotein E (APOE4). APOE genotype and biological sex are key modulators of microglial and astr...

    Authors: T. L. Stephen, B. Breningstall, S. Suresh, C. J. McGill and C. J. Pike
    Citation: Journal of Neuroinflammation 2022 19:286
  23. Aicardi–Goutières syndrome (AGS) is a severe neurodegenerative disease with clinical features of early-onset encephalopathy and progressive loss of intellectual abilities and motor control. Gene mutations in s...

    Authors: Xinfeng Guo, Richard A. Steinman, Yi Sheng, Guodong Cao, Clayton A. Wiley and Qingde Wang
    Citation: Journal of Neuroinflammation 2022 19:285
  24. Due to the complexity of the mechanisms involved in epileptogenesis, the available antiseizure drugs (ASDs) do not meet clinical needs; hence, both the discovery of new ASDs and the elucidation of novel molecu...

    Authors: Yan Hu, Buliang Meng, Saige Yin, Meifeng Yang, Yilin Li, Naixin Liu, Shanshan Li, Yixiang Liu, Dandan Sun, Siyu Wang, Yinglei Wang, Zhe Fu, Yutong Wu, Ailan Pang, Jun Sun, Ying Wang…
    Citation: Journal of Neuroinflammation 2022 19:284
  25. Neuronal injury is considered a critical risk factor in the pathogenesis of most neurological and neuropsychiatric diseases. However, the underlying molecular mechanisms and identification of potential therape...

    Authors: Changmin Wang, Ye Li, Yuhang Yi, Guiyu Liu, Ruojing Guo, Liyan Wang, Tian Lan, Wenjing Wang, Xiao Chen, Shihong Chen and Shu Yan Yu
    Citation: Journal of Neuroinflammation 2022 19:283
  26. Plasma gelsolin (pGSN) is an important part of the blood actin buffer that prevents negative consequences of possible F-actin deposition in the microcirculation and has various functions during host immune res...

    Authors: Łukasz Suprewicz, Kiet A. Tran, Ewelina Piktel, Krzysztof Fiedoruk, Paul A. Janmey, Peter A. Galie and Robert Bucki
    Citation: Journal of Neuroinflammation 2022 19:282
  27. Microglia are involved in neuroinflammatory processes during diverse pathophysiological conditions. To date, the possible contribution of these cells to deoxynivalenol (DON)-induced brain inflammation and anor...

    Authors: Stéphanie Gaige, Rym Barbouche, Manon Barbot, Sarah Boularand, Michel Dallaporta, Anne Abysique and Jean-Denis Troadec
    Citation: Journal of Neuroinflammation 2022 19:280
  28. Traumatic brain injury (TBI) is characterized by massive changes in neuronal excitation, from acute excitotoxicity to chronic hyper- or hypoexcitability. Nuclear calcium signaling pathways are involved in tran...

    Authors: Albrecht Fröhlich, Florian Olde Heuvel, Rida Rehman, Sruthi Sankari Krishnamurthy, Shun Li, Zhenghui Li, David Bayer, Alison Conquest, Anna M. Hagenston, Albert Ludolph, Markus Huber-Lang, Tobias Boeckers, Bernd Knöll, Maria Cristina Morganti-Kossmann, Hilmar Bading and Francesco Roselli
    Citation: Journal of Neuroinflammation 2022 19:279
  29. Tauopathies are a group of neurodegenerative diseases where there is pathologic accumulation of hyperphosphorylated tau protein (ptau). The most common tauopathy is Alzheimer’s disease (AD), but chronic trauma...

    Authors: Jonathan D. Cherry, Zach H. Baucom, Kaleb G. Eppich, Daniel Kirsch, Erin R. Dixon, Yorghos Tripodis, Kevin F. Bieniek, Kurt Farrell, Kristen Whitney, Madeline Uretsky, John F. Crary, Dennis Dickson and Ann C. McKee
    Citation: Journal of Neuroinflammation 2022 19:278
  30. The increasing number of treatments that are now available to manage patients with multiple sclerosis (MS) highlights the need to develop biomarkers that can be used within the framework of individualized medi...

    Authors: Celia Camacho-Toledano, Isabel Machín-Díaz, Leticia Calahorra, María Cabañas-Cotillas, David Otaegui, Tamara Castillo-Triviño, Luisa María Villar, Lucienne Costa-Frossard, Manuel Comabella, Luciana Midaglia, José Manuel García-Domínguez, Jennifer García-Arocha, María Cristina Ortega and Diego Clemente
    Citation: Journal of Neuroinflammation 2022 19:277
  31. Diffuse midline glioma (DMG), formerly called diffuse intrinsic pontine glioma (DIPG), is a high-grade malignant pediatric brain tumor with a near-zero survival rate. To date, only radiation therapy provides m...

    Authors: Casper J. Pachocki and Elly M. Hol
    Citation: Journal of Neuroinflammation 2022 19:276
  32. Zinc finger E-box binding homeobox 1 (ZEB1) is a master modulator of the epithelial–mesenchymal transition (EMT), a process whereby epithelial cells undergo a series of molecular changes and express certain ch...

    Authors: Elham Poonaki, Ulf Dietrich Kahlert, Sven G. Meuth and Ali Gorji
    Citation: Journal of Neuroinflammation 2022 19:275
  33. Cerebral infection with the protozoan Toxoplasma gondii (T. gondii) is responsible for inflammation of the central nervous system (CNS) contributing to subtle neuronal alterations. Albeit essential for brain para...

    Authors: Caio Andreeta Figueiredo, Henning Peter Düsedau, Johannes Steffen, Stefanie Ehrentraut, Miklos P. Dunay, Gabor Toth, Dora Reglödi, Markus M. Heimesaat and Ildiko Rita Dunay
    Citation: Journal of Neuroinflammation 2022 19:274
  34. Thiamine (vitamin B1) is a cofactor for enzymes of central energy metabolism and its deficiency (TD) impairs oxidative phosphorylation, increases oxidative stress, and activates inflammatory processes that can...

    Authors: Larissa M. G. Cassiano, Marina S. Oliveira, Jeanne Pioline, Anna C. M. Salim and Roney S. Coimbra
    Citation: Journal of Neuroinflammation 2022 19:272
  35. Brachial plexus root avulsion (BPRA) is frequently caused by high-energy trauma including traffic accident and birth trauma, which will induces massive motoneurons (MNs) death as well as loss of motor and sens...

    Authors: Ke Zhong, Yu Huang, Prince last Mudenda Zilundu, Yaqiong Wang, Yingying Zhou, Guangyin Yu, Rao Fu, Sookja Kim Chung, Yamei Tang, Xiao Cheng and Lihua Zhou
    Citation: Journal of Neuroinflammation 2022 19:271

    The Correction to this article has been published in Journal of Neuroinflammation 2023 20:2

  36. Cladribine is a synthetic purine analogue that interferes with DNA synthesis and repair next to disrupting cellular proliferation in actively dividing lymphocytes. The compound is approved for the treatment of...

    Authors: Christina B. Schroeter, Leoni Rolfes, K. S. Sophie Gothan, Joel Gruchot, Alexander M. Herrmann, Stefanie Bock, Luca Fazio, Antonia Henes, Venu Narayanan, Steffen Pfeuffer, Christopher Nelke, Saskia Räuber, Niklas Huntemann, Eduardo Duarte-Silva, Vera Dobelmann, Petra Hundehege…
    Citation: Journal of Neuroinflammation 2022 19:270
  37. The microglia-mediated inflammatory response is a vital mechanism of secondary damage following traumatic brain injury (TBI), but the underlying mechanism of microglial activation is unclear.

    Authors: Pengzhan Zhao, Yutian Wei, Guangchi Sun, Lei Xu, Tian Wang, Yufei Tian, Honglu Chao, Yiming Tu and Jing Ji
    Citation: Journal of Neuroinflammation 2022 19:269
  38. The pathophysiology of sepsis may involve the activation of the NOD-type receptor containing the pyrin-3 domain (NLPR-3), mitochondrial and oxidative damages. One of the primary essential oxidation products is...

    Authors: Diogo Dominguini, Monique Michels, Leticia B. Wessler, Emilio L. Streck, Tatiana Barichello and Felipe Dal-Pizzol
    Citation: Journal of Neuroinflammation 2022 19:268
  39. Triggering receptor expressed on myeloid cells 2 (Trem2) plays a protective role in neurodegenerative diseases. By contrast, Trem2 functions can exacerbate tissue damage during respiratory viral or liver infec...

    Authors: Mihyun Hwang, Carine Savarin, Jihye Kim, Jennifer Powers, Natasha Towne, Hyunsuk Oh and Cornelia C. Bergmann
    Citation: Journal of Neuroinflammation 2022 19:267
  40. Immune cells play crucial roles after spinal cord injury (SCI). However, incomplete knowledge of immune contributions to injury and repair hinders development of SCI therapies. We leveraged single-cell observa...

    Authors: Elizabeth S. Fisher, Matthew A. Amarante, Natasha Lowry, Steven Lotz, Farhad Farjood, Sally Temple, Caitlin E. Hill and Thomas R. Kiehl
    Citation: Journal of Neuroinflammation 2022 19:266
  41. Encephalopathy of prematurity (EoP) affects approximately 30% of infants born < 32 weeks gestation and is highly associated with inflammation in the foetus. Here we evaluated the efficacy of montelukast, a cys...

    Authors: Abi G. Yates, Elena Kislitsyna, Carla Alfonso Martin, Jiaying Zhang, Amy L. Sewell, Ane Goikolea-Vives, Valerie Cai, Lama F. Alkhader, Aleksander Skaland, Basil Hammond, Ralica Dimitrova, Dafnis Batalle, Cathy Fernandes, A. David Edwards, Pierre Gressens, Claire Thornton…
    Citation: Journal of Neuroinflammation 2022 19:265
  42. People with spinal cord injury (SCI) frequently develop neuropathic pain (NP) that worsens disability and diminishes rehabilitation efficacy. Chronic NP is presently incurable due to poor understanding of unde...

    Authors: Lei Wang, Mehmet A. Gunduz, Ana T. Semeano, Enis C. Yılmaz, Feras A. H. Alanazi, Ozan B. Imir, Ulas Yener, Christian A. Arbelaez, Esteban Usuga and Yang D. Teng
    Citation: Journal of Neuroinflammation 2022 19:264
  43. Optic neuritis (ON) is a common manifestation of aquaporin-4 (AQP4) antibody seropositive neuromyelitis optica (NMO). The extent of tissue damage is frequently severe, often leading to loss of visual function,...

    Authors: Yuko Morita, Takahide Itokazu, Toru Nakanishi, Shin-ichiro Hiraga and Toshihide Yamashita
    Citation: Journal of Neuroinflammation 2022 19:263
  44. Glaucoma, the major cause of irreversible blindness worldwide, is characterized by progressive degeneration of retinal ganglion cells (RGCs). Current treatments for glaucoma only slow or partially prevent the ...

    Authors: Mengyuan Liu, Haibo Li, Rongliang Yang, Dan Ji and Xiaobo Xia
    Citation: Journal of Neuroinflammation 2022 19:262
  45. The aim of this study was to establish a complete retinal cell atlas of ischemia–reperfusion injury by single-cell RNA sequencing, and to explore the underlying mechanism of retinal ischemia–reperfusion injury...

    Authors: Yangyang Li, Yuwen Wen, Xiuxing Liu, Zhuang Li, Bingying Lin, Caibin Deng, Ziyu Yu, Yingting Zhu, Ling Zhao, Wenru Su and Yehong Zhuo
    Citation: Journal of Neuroinflammation 2022 19:261
  46. Forkhead-Box-Protein P3 (FoxP3) is a transcription factor and marker of regulatory T cells, converting naive T cells into Tregs that can downregulate the effector function of other T cells. We previously detec...

    Authors: Ahmad Samir Alfaar, Lucas Stürzbecher, Maria Diedrichs-Möhring, Marion Lam, Christophe Roubeix, Julia Ritter, Kathrin Schumann, Balasubramaniam Annamalai, Inga-Marie Pompös, Bärbel Rohrer, Florian Sennlaub, Nadine Reichhart, Gerhild Wildner and Olaf Strauß
    Citation: Journal of Neuroinflammation 2022 19:260
  47. Autoimmune encephalitis (AE) with neuronal surface antibodies (NSAbs) presents pathogenesis mediated by B cell-secreting antibodies. Rituximab is a second-line choice for the treatment for AE with NSAbs, which...

    Authors: Ying Du, Chao Zhao, Juntong Liu, Chuan Li, Qi Yan, Lin Li, Yunfeng Hao, Dan Yao, Huaxing Si, Yingjun Zhao and Wei Zhang
    Citation: Journal of Neuroinflammation 2022 19:259

    The Correction to this article has been published in Journal of Neuroinflammation 2022 19:309

  48. The causes of grey matter pathology and diffuse neuron injury in MS remain incompletely understood. Axonal stress signals arising from white matter lesions has been suggested to play a role in initiating this ...

    Authors: Benjamin D. S. Clarkson, Ethan Grund, Kenneth David, Renee K. Johnson and Charles L. Howe
    Citation: Journal of Neuroinflammation 2022 19:258

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