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124 result(s) for 'autism' within Journal of Neuroinflammation

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  1. Research focus in neuro-oncology has shifted in the last decades towards the exploration of tumor infiltration by a variety of immune cells and their products. T cells, macrophages, B cells, and mast cells (MC...

    Authors: Stavros Polyzoidis, Triantafyllia Koletsa, Smaro Panagiotidou, Keyoumars Ashkan and Theoharis C. Theoharides
    Citation: Journal of Neuroinflammation 2015 12:170
  2. The endotoxin hypothesis of neurodegeneration is the hypothesis that endotoxin causes or contributes to neurodegeneration. Endotoxin is a lipopolysaccharide (LPS), constituting much of the outer membrane of gr...

    Authors: Guy C. Brown
    Citation: Journal of Neuroinflammation 2019 16:180
  3. Arthropod-borne viruses or arbovirus, are most commonly associated with acute infections, resulting on various symptoms ranging from mild fever to more severe disorders such as hemorrhagic fever. Moreover, som...

    Authors: Marion Clé, Patrick Eldin, Laurence Briant, Annie Lannuzel, Yannick Simonin, Philippe Van de Perre, André Cabié and Sara Salinas
    Citation: Journal of Neuroinflammation 2020 17:233
  4. Major depressive disorder is a highly debilitating psychiatric disorder involving the dysfunction of different cell types in the brain. Microglia are the predominant resident immune cells in the brain and exhi...

    Authors: Haixia Wang, Yi He, Zuoli Sun, Siyu Ren, Mingxia Liu, Gang Wang and Jian Yang
    Citation: Journal of Neuroinflammation 2022 19:132
  5. Maternal immune activation (MIA) is a risk factor for neurodevelopmental disorders such as autism and schizophrenia, as well as seizure development...

    Authors: Elaine O’Loughlin, Janelle M. P. Pakan, Deniz Yilmazer-Hanke and Kieran W. McDermott
    Citation: Journal of Neuroinflammation 2017 14:212
  6. Maternal viral infection during pregnancy is associated with an increase in the incidence of psychiatric disorders with presumed neurodevelopmental origin, including autism spectrum disorders and schizophrenia. T...

    Authors: Géraldine Arrode-Brusés and Juan L Brusés
    Citation: Journal of Neuroinflammation 2012 9:83
  7. Gut microbiota has been found involved in neuronal functions and neurological disorders. Whether and how gut microbiota impacts chronic somatic pain disorders remain elusive.

    Authors: Pingchuan Ma, Rufan Mo, Huabao Liao, Chengjie Qiu, Genhao Wu, Caixia Yang, Yunxiao Zhang, Yiran Zhao and Xue-Jun Song
    Citation: Journal of Neuroinflammation 2022 19:169
  8. The term sepsis is used to designate a systemic condition of infection and inflammation associated with hemodynamic changes that result in organic dysfunction. Gestational sepsis can impair the development of ...

    Authors: Marcelo Gomes Granja, Letícia Pires Alves, Marina Leardini-Tristão, Michelle Edelman Saul, Letícia Coelho Bortoni, Flávia Maciel de Moraes, Erica Camila Ferreira, Bianca Portugal Tavares de Moraes, Victória Zerboni da Silva, Adrielle Ferreira Ribeiro dos Santos, Adriana Ribeiro Silva, Cassiano Felippe Gonçalves-de-Albuquerque, Victorio Bambini-Junior, Andrew S. Weyrich, Matthew T. Rondina, Guy A. Zimmerman…
    Citation: Journal of Neuroinflammation 2021 18:60
  9. Fragile X syndrome (FXS) is the leading cause of inheritable intellectual disability in male children, and is predominantly caused by a single gene mutation resulting in expanded trinucleotide CGG-repeats with...

    Authors: Milo Careaga, Tamanna Noyon, Kirin Basuta, Judy Van de Water, Flora Tassone, Randi J Hagerman and Paul Ashwood
    Citation: Journal of Neuroinflammation 2014 11:110
  10. The mechanisms by which neonatal inflammation leads to cognitive deficits in adulthood remain poorly understood. Inhibitory GABAergic synaptic transmission plays a vital role in controlling learning, memory an...

    Authors: Jing Rong, Yang Yang, Min Liang, Haiquan Zhong, Yingchun Li, Yichao Zhu, Sha Sha, Lei Chen and Rong Zhou
    Citation: Journal of Neuroinflammation 2023 20:15
  11. CDKL5 deficiency disorder (CDD), a severe neurodevelopmental disorder characterized by early onset epilepsy, intellectual disability, and autistic features, is caused by mutations in the CDKL5 gene. Evidence in a...

    Authors: Giuseppe Galvani, Nicola Mottolese, Laura Gennaccaro, Manuela Loi, Giorgio Medici, Marianna Tassinari, Claudia Fuchs, Elisabetta Ciani and Stefania Trazzi
    Citation: Journal of Neuroinflammation 2021 18:155
  12. Interferon α (IFNα) is a cytokine whose production is increased endogenously in response to viral infection and in autoimmune diseases such as systemic lupus erythematosus (SLE). An elevated IFNα signature has...

    Authors: Ernest Aw, Yingying Zhang and Michael Carroll
    Citation: Journal of Neuroinflammation 2020 17:340
  13. Inflammation and increases in inflammatory cytokines are common findings in psychiatric disorders such as schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD). Meta-analyses of studi...

    Authors: Heather K. Hughes, Houa Yang, Tyler A. Lesh, Cameron S. Carter and Paul Ashwood
    Citation: Journal of Neuroinflammation 2022 19:287
  14. Clinical studies show that prenatal alcohol exposure (PAE) results in effects that persist into adulthood. Experimental animal models of moderate PAE demonstrate that young adults with PAE display potentiated ...

    Authors: Joshua J. Sanchez, Shahani Noor, Suzy Davies, Daniel Savage and Erin D. Milligan
    Citation: Journal of Neuroinflammation 2017 14:254
  15. The existence of the neural control of mast cell functions has long been proposed. Mast cells (MCs) are localized in association with the peripheral nervous system (PNS) and the brain, where they are closely a...

    Authors: Huaping Xu, Xiaoyun Shi, Xin Li, Jiexin Zou, Chunyan Zhou, Wenfeng Liu, Huming Shao, Hongbing Chen and Linbo Shi
    Citation: Journal of Neuroinflammation 2020 17:356
  16. Persistent inflammation dysregulation and cognitive decline have been associated with several trauma- and stress-related disorders such as posttraumatic stress disorder (PTSD) and anxiety disorder. Despite the...

    Authors: Yuan Dong, Shuoshuo Li, Yiming Lu, Xiaoheng Li, Yajin Liao, Zhixin Peng, Yunfeng Li, Lin Hou, Zengqiang Yuan and Jinbo Cheng
    Citation: Journal of Neuroinflammation 2020 17:205
  17. Evidence suggests that cytokine imbalances may be at the root of deficits that occur in numerous neurodevelopmental disorders, including schizophrenia and autism spectrum disorder. Notably, while clinical studies...

    Authors: Tamara S. Bodnar, Charlis Raineki, Wladimir Wertelecki, Lyubov Yevtushok, Larisa Plotka, Irina Granovska, Natalya Zymak-Zakutnya, Alla Pashtepa, Alan Wells, Gordon Honerkamp-Smith, Claire D. Coles, Julie A. Kable, Christina D. Chambers and Joanne Weinberg
    Citation: Journal of Neuroinflammation 2020 17:39
  18. The extension of sepsis encompassing the preterm newborn’s brain is often overlooked due to technical challenges in this highly vulnerable population, yet it leads to substantial long-term neurodevelopmental d...

    Authors: Ekaterina P. Demina, Wyston C. Pierre, Annie L. A. Nguyen, Irene Londono, Bela Reiz, Chunxia Zou, Radhika Chakraberty, Christopher W. Cairo, Alexey V. Pshezhetsky and Gregory A. Lodygensky
    Citation: Journal of Neuroinflammation 2018 15:336
  19. Discoveries that microglia-mediated neuroinflammation is involved in the pathological process of depression provided a new strategy for novel antidepressant therapy. Peroxisome proliferator-activated receptor ...

    Authors: Qiuying Zhao, Xiaohui Wu, Shuo Yan, Xiaofang Xie, Yonghua Fan, Jinqiang Zhang, Cheng Peng and Zili You
    Citation: Journal of Neuroinflammation 2016 13:259
  20. Development of central nervous system (CNS) is regulated by both intrinsic and peripheral signals. Previous studies have suggested that environmental factors affect neurological activities under both physiolog...

    Authors: Qianquan Ma, Changsheng Xing, Wenyong Long, Helen Y. Wang, Qing Liu and Rong-Fu Wang
    Citation: Journal of Neuroinflammation 2019 16:53
  21. Although the exact etiology of obsessive-compulsive disorder (OCD) is unknown, there is growing evidence of a role for immune dysregulation in the pathophysiology of the disease, especially in the innate immun...

    Authors: Natalia Rodríguez, Astrid Morer, E. Azucena González-Navarro, Carles Serra-Pages, Daniel Boloc, Teresa Torres, Susana García-Cerro, Sergi Mas, Patricia Gassó and Luisa Lázaro
    Citation: Journal of Neuroinflammation 2017 14:261
  22. Chronic infection with the neurotropic parasite Toxoplasma gondii has been implicated in the risk for several neuropsychiatric disorders. The mechanisms, by which the parasite may alter neural function and behavi...

    Authors: Daniel Lang, Björn H. Schott, Marco van Ham, Lorena Morton, Leonora Kulikovskaja, Rodrigo Herrera-Molina, Rainer Pielot, Frank Klawonn, Dirk Montag, Lothar Jänsch, Eckart D. Gundelfinger, Karl Heinz Smalla and Ildiko Rita Dunay
    Citation: Journal of Neuroinflammation 2018 15:216
  23. CHI3L1 (YKL-40) is up-regulated in a variety of inflammatory conditions and cancers. We have previously reported elevated CHI3L1 concentration in the cerebrospinal fluid (CSF) of human and non-human primates w...

    Authors: Dafna Bonneh-Barkay, Guoji Wang, Adam Starkey, Ronald L Hamilton and Clayton A Wiley
    Citation: Journal of Neuroinflammation 2010 7:34
  24. The brain–gut–microbiota axis plays a role in the pathogenesis of stress-related disorders such as depression. In this study, we examined the effects of fecal microbiota transplantation (FMT) in mice with anti...

    Authors: Siming Wang, Tamaki Ishima, Jiancheng Zhang, Youge Qu, Lijia Chang, Yaoyu Pu, Yuko Fujita, Yunfei Tan, Xingming Wang and Kenji Hashimoto
    Citation: Journal of Neuroinflammation 2020 17:241
  25. Perinatal inflammation is a key factor of brain vulnerability in neonates born preterm or with intra-uterine growth restriction (IUGR), two leading conditions associated with brain injury and responsible for n...

    Authors: Manuela Zinni, Jérôme Mairesse, Julien Pansiot, Francesco Fazio, Luisa Iacovelli, Nico Antenucci, Rosamaria Orlando, Ferdinando Nicoletti, Daniel Vaiman and Olivier Baud
    Citation: Journal of Neuroinflammation 2021 18:13
  26. Stroke is associated with high disability and mortality rates and increases the incidence of organ-related complications. Research has revealed that the outcomes and prognosis of stroke are regulated by the st...

    Authors: Jinchen Wang, Yi Zhong, Hua Zhu, Omer Kamal Mahgoub, Zhihong Jian, Lijuan Gu and Xiaoxing Xiong
    Citation: Journal of Neuroinflammation 2022 19:245
  27. Studies have suggested that many down-regulated miRNAs identified in the brain tissue or serum of Alzheimer’s disease (AD) patients were involved in the formation of senile plaques and neurofibrillary tangles....

    Authors: Pengcheng Xia, Jing Chen, Yingchao Liu, Xiaolin Cui, Cuicui Wang, Shuai Zong, Le Wang and Zhiming Lu
    Citation: Journal of Neuroinflammation 2022 19:180
  28. Trigeminal ganglia (TG) neurons are the main site of lifelong latent herpes simplex virus type 1 (HSV-1) infection. T-cells in ganglia contribute to long-term control of latent HSV-1 infection, but it is uncle...

    Authors: Peter-Paul A. Unger, Anna E. Oja, Tamana Khemai-Mehraban, Werner J. D. Ouwendijk, Pleun Hombrink and Georges M. G. M. Verjans
    Citation: Journal of Neuroinflammation 2022 19:249
  29. Microglia are the tissue-resident macrophages of the CNS. They originate in the yolk sac, colonize the CNS during embryonic development and form a self-sustaining population with limited turnover. A consequenc...

    Authors: Xiaoming Zhang, Laura Kracht, Antonio M. Lerario, Marissa L. Dubbelaar, Nieske Brouwer, Evelyn M. Wesseling, Erik W. G. M. Boddeke, Bart J. L. Eggen and Susanne M. Kooistra
    Citation: Journal of Neuroinflammation 2022 19:111
  30. Little is known about the association between gut microbiota and intestinal injury under a state of chronic cerebral hypoperfusion (CCH). Here, the effects of gut microbiota and short-chain fatty acids (SCFAs)...

    Authors: Shao-Hua Su, Yi-Fang Wu, Qi Lin, Lin Zhang, Da-Peng Wang and Jian Hai
    Citation: Journal of Neuroinflammation 2022 19:313
  31. The postnatal period is a critical time window during which inflammatory events have significant and enduring effects on the brain, and as a consequence, induce alterations of emotional behavior and/or cogniti...

    Authors: Anne-Laure Dinel, Corinne Joffre, Pierre Trifilieff, Agnes Aubert, Aline Foury, Pascale Le Ruyet and Sophie Layé
    Citation: Journal of Neuroinflammation 2014 11:155
  32. Neuropsychiatric systemic lupus erythematosus (NPSLE) is a severe complication, which involves pathological damage to the brain and cognitive function. However, its exact mechanism of action still remains uncl...

    Authors: Li Lu, Hailin Wang, Xuan Liu, Liping Tan, Xiaoyue Qiao, Jiali Ni, Yang Sun, Jun Liang, Yayi Hou and Huan Dou
    Citation: Journal of Neuroinflammation 2021 18:229
  33. A20 (TNFAIP3) is a pleiotropic NFκB-dependent gene that terminates NFκB activation in response to inflammatory stimuli. The potent anti-inflammatory properties of A20 are well characterized in several organs. How...

    Authors: Renata Padilha Guedes, Eva Csizmadia, Herwig P Moll, Averil Ma, Christiane Ferran and Cleide Gonçalves da Silva
    Citation: Journal of Neuroinflammation 2014 11:122
  34. Astrocytes play a major role in preserving and restoring structural and physiological integrity following injury to the nervous system. After peripheral axotomy, reactive gliosis propagates within adjacent spi...

    Authors: Amanda Emirandetti, Gustavo F Simões, Renata G Zanon and Alexandre LR Oliveira
    Citation: Journal of Neuroinflammation 2010 7:31
  35. Activation of the peroxisome proliferator-activated receptor gamma (PPAR-γ) has been proposed as a possible neuroprotective strategy to slow down the progression of early Parkinson's disease (PD). Here we repo...

    Authors: Christine R Swanson, Valerie Joers, Viktoriya Bondarenko, Kevin Brunner, Heather A Simmons, Toni E Ziegler, Joseph W Kemnitz, Jeffrey A Johnson and Marina E Emborg
    Citation: Journal of Neuroinflammation 2011 8:91
  36. Apoptosis signal-regulating kinase 1 (ASK1) not only causes neuronal programmed cell death via the mitochondrial pathway but also is an essential component of the signalling cascade during microglial activatio...

    Authors: Yiying Zhang, Zhangyang Wang, Rongrong Wang, Lu Xia, Yiying Cai, Fangchao Tong, Yanqin Gao, Jing Ding and Xin Wang
    Citation: Journal of Neuroinflammation 2022 19:202
  37. Anti-IgLON5 disease is a rare neurological disorder associated with autoantibodies against the neuronal cell adhesion protein, IgLON5. Cellular investigations with human IgLON5 antibodies have suggested an ant...

    Authors: You Ni, Yifan Feng, Dingding Shen, Ming Chen, Xiaona Zhu, Qinming Zhou, Yining Gao, Jun Liu, Qi Zhang, Yuntian Shen, Lisheng Peng, Zike Zeng, Dou Yin, Ji Hu and Sheng Chen
    Citation: Journal of Neuroinflammation 2022 19:140
  38. Neuroinflammation mediated by microglia plays a central role in the pathogenesis of perinatal/neonatal brain injury, including cerebral palsy (CP). Therapeutics mitigating neuroinflammation potentially provide...

    Authors: Zhi Zhang, Yi-An Lin, Soo-Young Kim, Lilly Su, Jinhuan Liu, Rangaramanujam M. Kannan and Sujatha Kannan
    Citation: Journal of Neuroinflammation 2020 17:319
  39. Hypoxic-ischemic encephalopathy (HIE) is an important cause of permanent damage to central nervous system (CNS) that may result in neonatal death or manifest later as mental retardation, epilepsy, cerebral pal...

    Authors: John Sieh Dumbuya, Lu Chen, Jang-Yen Wu and Bin Wang
    Citation: Journal of Neuroinflammation 2021 18:55
  40. Western pattern diets induce neuroinflammation and impair cognitive behavior in humans and animals. Neuroinflammation and cognitive impairment have been associated with microbiota dysbiosis, through the gut-br...

    Authors: Hongli Shi, Qiao Wang, Mingxuan Zheng, Shanshan Hao, Jeremy S. Lum, Xi Chen, Xu-Feng Huang, Yinghua Yu and Kuiyang Zheng
    Citation: Journal of Neuroinflammation 2020 17:77
  41. Emerging evidence indicates that long-time use of multiple antibiotics can induce cognitive dysfunction via gut dysbiosis. Cefazolin is often used for 3 to 5 days to prevent perioperative infection. This study...

    Authors: Peng Liang, Weiran Shan and Zhiyi Zuo
    Citation: Journal of Neuroinflammation 2018 15:235
  42. Neuraminidase (NA) is a sialidase present, among various locations, in the envelope/membrane of some bacteria/viruses (e.g., influenza virus), and is involved in infectiveness and/or dispersion. The administra...

    Authors: María del Mar Fernández-Arjona, Jesús M. Grondona, Pedro Fernández-Llebrez and María Dolores López-Ávalos
    Citation: Journal of Neuroinflammation 2019 16:245
  43. Traumatic brain injury (TBI) triggers both immediate (primary) and long-term (secondary) tissue damages. Secondary damages can last from hours to days or even a lifetime. Secondary damages implicate several me...

    Authors: Weiqiang Chen, Jiangtao Sheng, Jingfang Guo, Guoyi Peng, Jinfang Hong, Bingbing Li, Xiaoxuan Chen, Kangsheng Li and Shousen Wang
    Citation: Journal of Neuroinflammation 2017 14:73

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