Table 3 Ginkgolides reduce prostaglandin E₂ production: Levels of prostaglandin E₂ produced by untreated SH-SY5Y cells, or cells pre-treated with 1 μM ginkgolide A, 1 μM ginkgolide B, 25 μM myricetin or 25 μM quercetin and thereafter incubated for 24 hours with 10 μM arachidonic acid, 10 μM amyloid-β_1-42 10 μM HuPrP82-146 or 5 μM PAF. Each value is the mean level of prostaglandin E₂ (pg/ml) ± SD from triplicate experiments repeated three times (9 observations).

Medium

<20

362 ± 46

323 ± 39

438 ± 55

157 ± 38

ginkgolide A

<20

66 ± 40**

57 ± 40**

234 ± 34**

45 ± 29**

ginkgolide B

<20

<20**

25 ± 27**

145 ± 30**

36 ± 26**

myricetin

<20

358 ± 64

327 ± 36

450 ± 30

149 ± 28

quercetin

<20

349 ± 51

319 ± 28

442 ± 45

169 ± 29