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  1. Research

    A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation

    Kv1.3 potassium channels regulate microglial functions and are overexpressed in neuroinflammatory diseases. Kv1.3 blockade may selectively inhibit pro-inflammatory microglia in neurological diseases but the mo...

    Srikant Rangaraju, Syed Ali Raza, Andrea Pennati, Qiudong Deng, Eric B. Dammer, Duc Duong, Michael W. Pennington, Malu G. Tansey, James J. Lah, Ranjita Betarbet, Nicholas T. Seyfried and Allan I. Levey

    Journal of Neuroinflammation 2017 14:128

    Published on: 26 June 2017

  2. Research

    Evidence for an early innate immune response in the motor cortex of ALS

    Recent evidence indicates the importance of innate immunity and neuroinflammation with microgliosis in amyotrophic lateral sclerosis (ALS) pathology. The MCP1 (monocyte chemoattractant protein-1) and CCR2 (CC ...

    Javier H. Jara, Barış Genç, Macdonell J. Stanford, Peter Pytel, Raymond P. Roos, Sandra Weintraub, M. Marsel Mesulam, Eileen H. Bigio, Richard J. Miller and P. Hande Özdinler

    Journal of Neuroinflammation 2017 14:129

    Published on: 26 June 2017

  3. Short Report

    Influence of type I IFN signaling on anti-MOG antibody-mediated demyelination

    Antibodies with specificity for myelin oligodendrocyte glycoprotein (MOG) are implicated in multiple sclerosis and related diseases. The pathogenic importance of anti-MOG antibody in primary demyelinating path...

    Carsten Tue Berg, Reza Khorooshi, Nasrin Asgari and Trevor Owens

    Journal of Neuroinflammation 2017 14:127

    Published on: 24 June 2017

  4. Research

    The increased concentration of macrophage migration inhibitory factor in serum and cerebrospinal fluid of patients with tick-borne encephalitis

    Host factors determining the clinical presentation of tick-borne encephalitis (TBE) are not fully elucidated. The peripheral inflammatory response to TBE virus is hypothesized to facilitate its entry into cent...

    Sambor Grygorczuk, Miłosz Parczewski, Renata Świerzbińska, Piotr Czupryna, Anna Moniuszko, Justyna Dunaj, Maciej Kondrusik and Sławomir Pancewicz

    Journal of Neuroinflammation 2017 14:126

    Published on: 24 June 2017

  5. Research

    Herpes simplex virus-1 infects the olfactory bulb shortly following ocular infection and exhibits a long-term inflammatory profile in the form of effector and HSV-1-specific T cells

    Herpes simplex virus 1 (HSV-1) infection can result in a life-threatening condition known as herpes simplex encephalitis (HSE). Trafficking patterns by which the virus reaches the central nervous system (CNS) ...

    Chandra M. Menendez and Daniel J. J. Carr

    Journal of Neuroinflammation 2017 14:124

    Published on: 23 June 2017

  6. Research

    Interleukin-1 receptor type 1 is overexpressed in neurons but not in glial cells within the rat superficial spinal dorsal horn in complete Freund adjuvant-induced inflammatory pain

    All known biological functions of the pro-inflammatory cytokine interleukin-1β (IL-1β) are mediated by type 1 interleukin receptor (IL-1R1). IL-1β–IL-1R1 signaling modulates various neuronal functions includin...

    Krisztina Holló, László Ducza, Zoltán Hegyi, Klaudia Dócs, Krisztina Hegedűs, Erzsébet Bakk, Ildikó Papp, Gréta Kis, Zoltán Mészár, Zsuzsanna Bardóczi and Miklós Antal

    Journal of Neuroinflammation 2017 14:125

    Published on: 23 June 2017

  7. Research

    Rapid monocyte infiltration following retinal detachment is dependent on non-canonical IL6 signaling through gp130

    Retinal detachment (RD) can lead to proliferative vitreoretinopathy (PVR), a leading cause of intractable vision loss. PVR is associated with a cytokine storm involving common proinflammatory molecules like IL...

    Xinlei Wang, Eric B. Miller, Mayank Goswami, Pengfei Zhang, Kaitryn E. Ronning, Sarah J. Karlen, Robert J. Zawadzki, Edward N. Pugh and Marie E. Burns

    Journal of Neuroinflammation 2017 14:121

    Published on: 23 June 2017

  8. Research

    Identification of the flotillin-1/2 heterocomplex as a target of autoantibodies in bona fide multiple sclerosis

    Autoantibodies, in particular those against aquaporin-4 and myelin-oligodendrocyte glycoprotein (MOG), aid as biomarkers in the differential diagnosis of demyelination. Here, we report on discovery of autoanti...

    S. Hahn, G. Trendelenburg, M. Scharf, Y. Denno, S. Brakopp, B. Teegen, C. Probst, K. P. Wandinger, M. Buttmann, A. Haarmann, F. Szabados, M. vom Dahl, T. Kümpfel, P. Eichhorn, H. Gold, F. Paul…

    Journal of Neuroinflammation 2017 14:123

    Published on: 23 June 2017

  9. Research

    Sac-1004, a vascular leakage blocker, reduces cerebral ischemia—reperfusion injury by suppressing blood–brain barrier disruption and inflammation

    Blood–brain barrier (BBB) breakdown and inflammation are critical events in ischemic stroke, contributing to aggravated brain damage. The BBB mainly consists of microvascular endothelial cells sealed by tight ...

    Haiying Zhang, Joon Ha Park, Sony Maharjan, Jeong Ae Park, Kyu-Sung Choi, Hyojin Park, Yoonjeong Jeong, Ji Hyeon Ahn, In Hye Kim, Jae-Chul Lee, Jeong Hwi Cho, In-Kyu Lee, Choong Hyun Lee, In Koo Hwang, Young-Myeong Kim, Young-Ger Suh…

    Journal of Neuroinflammation 2017 14:122

    Published on: 23 June 2017

  10. Research

    Natural IgM antibodies that bind neoepitopes exposed as a result of spinal cord injury , drive secondary injury by activating complement

    Natural IgM antibodies (Abs) function as innate immune sensors of injury via recognition of neoepitopes expressed on damaged cells, although how this recognition systems function following spinal cord injury (...

    Aarti Narang, Fei Qiao, Carl Atkinson, Hong Zhu, Xiaofeng Yang, Liudmila Kulik, V. Michael Holers and Stephen Tomlinson

    Journal of Neuroinflammation 2017 14:120

    Published on: 19 June 2017

  11. Research

    Isoliquiritigenin alleviates early brain injury after experimental intracerebral hemorrhage via suppressing ROS- and/or NF-κB-mediated NLRP3 inflammasome activation by promoting Nrf2 antioxidant pathway

    Intracerebral hemorrhage (ICH) induces potently oxidative stress responses and inflammatory processes. Isoliquiritigenin (ILG) is a flavonoid with a chalcone structure and can activate nuclear factor erythroid...

    Jun Zeng, Yizhao Chen, Rui Ding, Liang Feng, Zhenghao Fu, Shuo Yang, Xinqing Deng, Zhichong Xie and Shizhong Zheng

    Journal of Neuroinflammation 2017 14:119

    Published on: 13 June 2017

  12. Research

    YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer’s disease and other tauopathies

    The innate immune system is known to be involved early in the pathogenesis of Alzheimer’s disease (AD) and other neurodegenerative disorders. The inflammatory response in the central nervous system can be meas...

    Marta Querol-Vilaseca, Martí Colom-Cadena, Jordi Pegueroles, Carla San Martín-Paniello, Jordi Clarimon, Olivia Belbin, Juan Fortea and Alberto Lleó

    Journal of Neuroinflammation 2017 14:118

    Published on: 9 June 2017

  13. Review

    Regulatory T cells in multiple sclerosis and myasthenia gravis

    Multiple sclerosis (MS) is a chronic debilitating disease of the central nervous system primarily mediated by T lymphocytes with specificity to neuronal antigens in genetically susceptible individuals. On the ...

    K. M. Danikowski, S. Jayaraman and B. S. Prabhakar

    Journal of Neuroinflammation 2017 14:117

    Published on: 9 June 2017

  14. Research

    Differential expression of Cathepsin E in transthyretin amyloidosis: from neuropathology to the immune system

    Increasing evidence supports a key role for inflammation in the neurodegenerative process of familial amyloidotic polyneuropathy (FAP). While there seems to be an overactivation of the neuronal interleukin-1 s...

    Nádia Pereira Gonçalves, João Moreira, Diana Martins, Paulo Vieira, Laura Obici, Giampaolo Merlini, Margarida Saraiva and Maria João Saraiva

    Journal of Neuroinflammation 2017 14:115

    Published on: 6 June 2017

  15. Research

    Effects of phosphodiesterase 3A modulation on murine cerebral microhemorrhages

    Cerebral microbleeds (CMB) are MRI-demonstrable cerebral microhemorrhages (CMH) which commonly coexist with ischemic stroke. This creates a challenging therapeutic milieu, and a strategy that simultaneously pr...

    Rachita K. Sumbria, Vitaly Vasilevko, Mher Mahoney Grigoryan, Annlia Paganini-Hill, Ronald Kim, David H. Cribbs and Mark J. Fisher

    Journal of Neuroinflammation 2017 14:114

    Published on: 5 June 2017

  16. Research

    Serum thyroid-stimulating hormone and interleukin-8 levels in boys with autism spectrum disorder

    Autism spectrum disorder (ASD) affects approximately 1 in 68 children in the USA. An ASD blood biomarker may enable early diagnosis and/or identification of new therapeutic targets. Serum samples from ASD and ...

    Sarika Singh, Umar Yazdani, Bharathi Gadad, Sayed Zaman, Linda S. Hynan, Nichole Roatch, Claire Schutte, C. Nathan Marti, Laura Hewitson and Dwight C. German

    Journal of Neuroinflammation 2017 14:113

    Published on: 2 June 2017

  17. Short Report

    B cells do not have a major pathophysiologic role in acute ischemic stroke in mice

    Lymphocytes have been shown to play an important role in the pathophysiology of acute ischemic stroke, but the properties of B cells remain controversial. The aim of this study was to unravel the role of B cel...

    Michael K. Schuhmann, Friederike Langhauser, Peter Kraft and Christoph Kleinschnitz

    Journal of Neuroinflammation 2017 14:112

    Published on: 2 June 2017

  18. Research

    MicroRNA-101a regulates microglial morphology and inflammation

    Microglia, as well as other tissue-resident macrophages, arise from yolk sac progenitors. Thus, it is likely that the central nervous system environment is critical for the acquisition of a distinct microglial...

    Reiko Saika, Hiroshi Sakuma, Daisuke Noto, Shuhei Yamaguchi, Takashi Yamamura and Sachiko Miyake

    Journal of Neuroinflammation 2017 14:109

    Published on: 30 May 2017

  19. Research

    Receptor tyrosine kinases play a significant role in human oligodendrocyte inflammation and cell death associated with the Lyme disease bacterium Borrelia burgdorferi

    In previous studies, human oligodendrocytes were demonstrated to undergo apoptosis in the presence of Borrelia burgdorferi under an inflammatory milieu. Subsequently, we determined that the MEK/ERK pathway played...

    Geetha Parthasarathy and Mario T. Philipp

    Journal of Neuroinflammation 2017 14:110

    Published on: 30 May 2017

  20. Review

    Pathophysiology of chronic subdural haematoma: inflammation, angiogenesis and implications for pharmacotherapy

    Chronic subdural haematoma (CSDH) is an encapsulated collection of blood and fluid on the surface of the brain. Historically considered a result of head trauma, recent evidence suggests there are more complex ...

    Ellie Edlmann, Susan Giorgi-Coll, Peter C. Whitfield, Keri L. H. Carpenter and Peter J. Hutchinson

    Journal of Neuroinflammation 2017 14:108

    Published on: 30 May 2017

  21. Research

    Inhibition of colony-stimulating factor 1 receptor early in disease ameliorates motor deficits in SCA1 mice

    Polyglutamine (polyQ) expansion in the protein Ataxin-1 (ATXN1) causes spinocerebellar ataxia type 1 (SCA1), a fatal dominantly inherited neurodegenerative disease characterized by motor deficits, cerebellar n...

    Wenhui Qu, Andrea Johnson, Joo Hyun Kim, Abigail Lukowicz, Daniel Svedberg and Marija Cvetanovic

    Journal of Neuroinflammation 2017 14:107

    Published on: 25 May 2017

  22. Research

    LPS-induced systemic inflammation reveals an immunomodulatory role for the prion protein at the blood-brain interface

    The cellular prion protein (PrPC) is an evolutionary conserved protein abundantly expressed not only in the central nervous system but also peripherally including the immune system. A line of Norwegian dairy goat...

    Ø. Salvesen, M. R. Reiten, A. Espenes, M. K. Bakkebø, M. A. Tranulis and C. Ersdal

    Journal of Neuroinflammation 2017 14:106

    Published on: 22 May 2017

  23. Research

    Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation

    The influx of leukocytes into the central nervous system (CNS) is a key hallmark of the chronic neuro-inflammatory disease multiple sclerosis (MS). Strategies that aim to inhibit leukocyte migration across the...

    Suzanne A. B. M. Aarts, Tom T. P. Seijkens, Pascal J. H. Kusters, Susanne M. A. van der Pol, Barbara Zarzycka, Priscilla D. A. M. Heijnen, Linda Beckers, Myrthe den Toom, Marion J. J. Gijbels, Louis Boon, Christian Weber, Helga E. de Vries, Gerry A. F. Nicolaes, Christine D. Dijkstra, Gijs Kooij and Esther Lutgens

    Journal of Neuroinflammation 2017 14:105

    Published on: 12 May 2017

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